Faculty Opinions recommendation of Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection.

2013 ◽  
Author(s):  
Booki Min
Keyword(s):  
Fungal Infection ◽  
Host Defense ◽  
Innate Lymphoid Cells ◽  
Cutting Edge ◽  
Lymphoid Cells

scholarly journals Cutting Edge: IL-17–Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

2012 ◽  
Vol 190 (2) ◽  
pp. 521-525 ◽  
Author(s):  
André Gladiator ◽  
Nicolette Wangler ◽  
Kerstin Trautwein-Weidner ◽  
Salomé LeibundGut-Landmann
Keyword(s):  
Fungal Infection ◽  
Host Defense ◽  
Innate Lymphoid Cells ◽  
Cutting Edge ◽  
Lymphoid Cells

scholarly journals Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens

2021 ◽  
Vol 63 ◽  
pp. 83-91
Author(s):  
Angélique Jarade ◽  
James P Di Santo ◽  
Nicolas Serafini
Keyword(s):  
Host Defense ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3

scholarly journals NK cells and type 1 innate lymphoid cells: partners in host defense

2016 ◽  
Vol 17 (7) ◽  
pp. 758-764 ◽  
Author(s):  
Hergen Spits ◽  
Jochem H Bernink ◽  
Lewis Lanier
Keyword(s):  
Nk Cells ◽  
Host Defense ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells

2021 ◽  
Vol 118 (41) ◽  
pp. e2106634118
Author(s):  
Hong Bing Yu ◽  
Hyungjun Yang ◽  
Joannie M. Allaire ◽  
Caixia Ma ◽  
Franziska A. Graef ◽  
...  
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Host Defense ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Enteric Pathogens ◽  
Lymphoid Tissues ◽  
Homing Receptor ◽  
Local Populations ◽  
Ccr9 Expression ◽  
Group 3

Group 3 innate lymphoid cells (ILC3s) control the formation of intestinal lymphoid tissues and play key roles in intestinal defense. They express neuropeptide vasoactive intestinal peptide (VIP) receptor 2 (VPAC2), through which VIP modulates their function, but whether VIP exerts other effects on ILC3 remains unclear. We show that VIP promotes ILC3 recruitment to the intestine through VPAC1 independent of the microbiota or adaptive immunity. VIP is also required for postnatal formation of lymphoid tissues as well as the maintenance of local populations of retinoic acid (RA)–producing dendritic cells, with RA up-regulating gut-homing receptor CCR9 expression by ILC3s. Correspondingly, mice deficient in VIP or VPAC1 suffer a paucity of intestinal ILC3s along with impaired production of the cytokine IL-22, rendering them highly susceptible to the enteric pathogen Citrobacter rodentium. This heightened susceptibility to C. rodentium infection was ameliorated by RA supplementation, adoptive transfer of ILC3s, or by recombinant IL-22. Thus, VIP regulates the recruitment of intestinal ILC3s and formation of postnatal intestinal lymphoid tissues, offering protection against enteric pathogens.

scholarly journals Cutting Edge: Innate Lymphoid Cells Suppress Homeostatic T Cell Expansion in Neonatal Mice

2016 ◽  
Vol 196 (9) ◽  
pp. 3532-3536 ◽  
Author(s):  
Ute Bank ◽  
Katrin Deiser ◽  
Daniela Finke ◽  
Günter J. Hämmerling ◽  
Bernd Arnold ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Expansion ◽  
Innate Lymphoid Cells ◽  
Cutting Edge ◽  
Lymphoid Cells ◽  
Neonatal Mice ◽  
T Cell Expansion

scholarly journals S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

Science ◽  
2018 ◽  
Vol 359 (6371) ◽  
pp. 114-119 ◽  
Author(s):  
Yuefeng Huang ◽  
Kairui Mao ◽  
Xi Chen ◽  
Ming-an Sun ◽  
Takeshi Kawabe ◽  
...  
Keyword(s):  
Host Defense ◽  
Tissue Repair ◽  
Inflammatory Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Sphingosine 1 Phosphate ◽  
Distant Tissue ◽  
Group 2 ◽  
And Migration ◽  
Interleukin 25

Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have been considered to be tissue-resident cells, but whether ILCs move between tissue sites during infection has been unclear. We show here that interleukin-25– or helminth-induced inflammatory ILC2s are circulating cells that arise from resting ILC2s residing in intestinal lamina propria. They migrate to diverse tissues based on sphingosine 1-phosphate (S1P)–mediated chemotaxis that promotes lymphatic entry, blood circulation, and accumulation in peripheral sites, including the lung, where they contribute to anti-helminth defense and tissue repair. This ILC2 expansion and migration is a behavioral parallel to the antigen-driven proliferation and migration of adaptive lymphocytes to effector sites and indicates that ILCs complement adaptive immunity by providing both local and distant tissue protection during infection.

scholarly journals Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis

2018 ◽  
Vol 200 (4) ◽  
pp. 1249-1254 ◽  
Author(s):  
Alina Soare ◽  
Stefanie Weber ◽  
Lisa Maul ◽  
Simon Rauber ◽  
Ana Maria Gheorghiu ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Innate Lymphoid Cells ◽  
Cutting Edge ◽  
Lymphoid Cells
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