Faculty Opinions recommendation of Small-molecule binding sites on proteins established by paramagnetic NMR spectroscopy.

2013 ◽  
Author(s):  
Antonio Rosato
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecule ◽  
Binding Sites ◽  
Paramagnetic Nmr

Small-Molecule Binding Sites on Proteins Established by Paramagnetic NMR Spectroscopy

2013 ◽  
Vol 135 (15) ◽  
pp. 5859-5868 ◽  
Author(s):  
Jia-Ying Guan ◽  
Peter H. J. Keizers ◽  
Wei-Min Liu ◽  
Frank Löhr ◽  
Simon P. Skinner ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecule ◽  
Binding Sites ◽  
Paramagnetic Nmr

Identification of Small Molecule Binding Sites within Proteins Using Phage Display Technology

2001 ◽  
Vol 4 (7) ◽  
pp. 553-572 ◽  
Author(s):  
D. Rodi ◽  
G. Agoston ◽  
R. Manon ◽  
R. Lapcevich ◽  
S. Green ◽  
...  
Keyword(s):  
Phage Display ◽  
Small Molecule ◽  
Binding Sites ◽  
Phage Display Technology ◽  
Display Technology

Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

2020 ◽  
Vol 20 (11) ◽  
pp. 1017-1030
Author(s):  
Haonan Zhang ◽  
Zhengquan Gao ◽  
Chunxiao Meng ◽  
Xiangqian Li ◽  
Dayong Shi
Keyword(s):  
Small Molecule ◽  
Protein Tyrosine Phosphatase ◽  
Binding Sites ◽  
Drug Target ◽  
Tyrosine Phosphatase ◽  
Cancer Drug ◽  
Cellular Activity ◽  
Binding Modes ◽  
Inhibitor Binding ◽  
Protein Tyrosine

Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of selective SHP-2 inhibitors. In this review, we describe the binding modes of existing inhibitors and SHP-2 binding sites, summarize the characteristics of the sites involved in selectivity, and identify the suitable groups for interaction with the binding sites.

scholarly journals Binding Sites for Oligosaccharide Repeats from Lactic Acid Bacteria Exopolysaccharides on Bovine β-Lactoglobulin Identified by NMR Spectroscopy

ACS Omega ◽  
2021 ◽  
Author(s):  
Johnny Birch ◽  
Sanaullah Khan ◽  
Mikkel Madsen ◽  
Christian Kjeldsen ◽  
Marie Sofie Møller ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Nmr Spectroscopy ◽  
Lactic Acid Bacteria ◽  
Binding Sites ◽  
Β Lactoglobulin

Installation of a Rigid EDTA-Like Motif into a Protein α-Helix for Paramagnetic NMR Spectroscopy with Cobalt(II) Ions

2015 ◽  
Vol 22 (4) ◽  
pp. 1228-1232 ◽  
Author(s):  
James D. Swarbrick ◽  
Phuc Ung ◽  
Matthew L. Dennis ◽  
Michael D. Lee ◽  
Sandeep Chhabra ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Paramagnetic Nmr ◽  
Α Helix

Implementing one-shot multiple-FID acquisition into homonuclear and heteronuclear NMR experiments

2018 ◽  
Vol 54 (96) ◽  
pp. 13507-13510 ◽  
Author(s):  
Kumar Motiram-Corral ◽  
Míriam Pérez-Trujillo ◽  
Pau Nolis ◽  
Teodor Parella
Keyword(s):  
Nmr Spectroscopy ◽  
Small Molecule ◽  
Efficient Solution ◽  
Heteronuclear Nmr ◽  
Pulse Sequences

The concept of multiple-FID acquisition (MFA) within the same scan is applied to acquire simultaneously multiple 2D spectra from a single NMR experiment. A discussion on the incorporation of the MFA strategy in homonuclear and heteronuclear pulse sequences is presented. Several novel COSY- and HMBC-type experiments are reported as a time-efficient solution in small-molecule NMR spectroscopy.

Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds

2017 ◽  
Vol 53 (99) ◽  
pp. 13205-13208 ◽  
Author(s):  
Michael D. Lee ◽  
Matthew L. Dennis ◽  
Bim Graham ◽  
James D. Swarbrick
Keyword(s):  
Nmr Spectroscopy ◽  
Paramagnetic Nmr ◽  
Nmr Studies ◽  
Lanthanide Binding Tags

A new pair of enantiomeric two-armed lanthanide-binding tags have been developed for paramagnetic NMR studies of proteins.

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