Faculty Opinions recommendation of Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.

2013 ◽  
Author(s):  
YS Prakash ◽  
Bharathi Aravamudan
Keyword(s):  
Respiratory Tract ◽  
Airway Hyperreactivity

Respiratory Manifestations of Food Allergy

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_3) ◽  
pp. 1625-1630
Author(s):  
John M. James
Keyword(s):  
Food Allergy ◽  
Respiratory Tract ◽  
Immunoglobulin E ◽  
Food Additives ◽  
Airway Hyperreactivity ◽  
Severe Atopic Dermatitis ◽  
Increased Risk ◽  
Food Particles ◽  
Food Challenges

Food allergy may present with a variety of respiratory tract symptoms that generally involve immunoglobulin E antibody-mediated responses. Exposure is typically through ingestion, but in some cases, inhalation of airborne food particles may trigger these reactions. Upper and lower respiratory tract reactions are often a significant component of multisystem, anaphylactic reactions. However, chronic or isolated asthma or rhinitis induced by food is unusual. It is important to recognize that food allergy in early childhood is a marker indicating an increased risk to develop respiratory allergy. The role of food allergy in otitis media is controversial and probably is extremely rare. Likewise, asthmatic responses to food additives can occur but are uncommon. Studies using blinded oral food challenges have demonstrated that foods can elicit airway hyperreactivity and asthmatic responses. Therefore, an evaluation for food allergy should be considered in patients who are at risk, including those with recalcitrant or otherwise unexplained acute, severe asthma exacerbations, asthma triggered after ingestion of particular foods, and asthma that is accompanied by other manifestations of food allergy (eg, anaphylaxis, moderate to severe atopic dermatitis).

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

2013 ◽  
Vol 5 (186) ◽  
pp. 186ra67-186ra67 ◽  
Author(s):  
T. S. Worgall ◽  
A. Veerappan ◽  
B. Sung ◽  
B. I. Kim ◽  
E. Weiner ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Airway Hyperreactivity

New Ultrastructural Observations on Injury and Regeneration of Cilia in Mammalian Conducting Airway Epithelium

1981 ◽  
Vol 39 ◽  
pp. 624-625
Author(s):  
J.L. Carson ◽  
A.M. Collier
Keyword(s):  
Respiratory Tract ◽  
Airway Epithelium ◽  
Defense Mechanisms ◽  
Normal Growth ◽  
Fetal Lung ◽  
Secretory Cells ◽  
Airway Epithelial ◽  
Ciliated Cells ◽  
Conducting Airway ◽  
Conducting Airways

The ciliated cells lining the conducting airways of mammals are integral to the defense mechanisms of the respiratory tract, functioning in coordination with secretory cells in the removal of inhaled and cellular debris. The effects of various infectious and toxic agents on the structure and function of airway epithelial cell cilia have been studied in our laboratory, both of which have been shown to affect ciliary ultrastructure.These observations have led to questions about ciliary regeneration as well as the possible induction of ciliogenesis in response to cellular injury. Classical models of ciliogenesis in the conducting airway epithelium of the mammalian respiratory tract have been based primarily on observations of the developing fetal lung. These observations provide a plausible explanation for the embryological generation of ciliary beds lining the conducting airways but do little to account for subsequent differentiation of ciliated cells and ciliogenesis during normal growth and development.

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