Faculty Opinions recommendation of Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease.

2014 ◽  
Author(s):  
Yoko Ogawa
Keyword(s):  
T Cell ◽  
Dry Eye ◽  
Ocular Surface ◽  
Chemokine Receptors ◽  
Dry Eye Disease ◽  
Cd4 T Cell ◽  
Ocular Surface Disease ◽  
Eye Disease

scholarly journals Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4+ T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78508 ◽  
Author(s):  
Terry G. Coursey ◽  
Niral B. Gandhi ◽  
Eugene A. Volpe ◽  
Stephen C. Pflugfelder ◽  
Cintia S. de Paiva
Keyword(s):  
T Cell ◽  
Dry Eye ◽  
Ocular Surface ◽  
Chemokine Receptors ◽  
Dry Eye Disease ◽  
Cd4 T Cell ◽  
Ocular Surface Disease ◽  
Eye Disease

scholarly journals Pepys's Eyes: A Modern Answer to an Old Conundrum?

2020 ◽  
Vol 3 (1) ◽  
pp. e27-e40
Author(s):  
David Harries
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Diagnostic Algorithm ◽  
Dry Eye Disease ◽  
Ocular Surface Disease ◽  
Eye Disease ◽  
Samuel Pepys

Samuel Pepys was forced to abandon his renowned diary because of increasing pain and fear of impending blindness. In addition to having refraction errors, it has been suggested that he may have had ocular surface disease to account for his hitherto unexplained photophobia. This article uses new resources to re-examine Pepys’s symptoms working on the hypothesis that he suffered from dry eye disease. Applying the diagnostic algorithm provided by DEWS II corroborates the hypothesis and provides the basis of a unifying diagnosisof eye strain similar to digital eye strain that would explain all of his symptoms.

scholarly journals The effect of tamarind seed polysaccharidecontaining eye drop in dry eye syndrome: Results of an interventional, comparative, clinical study

2021 ◽  
Vol 2 (2) ◽  
pp. 71-76
Author(s):  
Naser Nozari ◽  
Shahrokh Ramin
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Ocular Surface Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Artificial Tears ◽  
Mean Values ◽  
The Mean ◽  
Contralateral Eye

Background: The mainstay of dry eye treatment is artificial tear solutions. Contralateral eye comparison of 2 types of artificial tears (Xiloial versus Tearlose) in managing dry eye disease was sought in this study. Methods: This study was a prospective, interventional, contralateral eye comparison of 2 types of artificial tears used for managing dry eye disease. The study participants were categorized into mild (13–22 points), moderate (23–32 points), or severe (33–100 points) ocular surface disease according to the baseline ocular surface disease index (OSDI) questionnaire score. Schirmer I and tear film break-up time (TBUT) tests, as well as detailed slit-lamp examinations, were performed at baseline and at the end of the study. All participants received Xiloial monodose eye drops for the right eye and Tearlose eye drops for the left eye, administered as a single drop 4 times per day. Furthermore, they were instructed to perform lid hygiene every 12 hours per day for both eyes. Results: Thirty-five patients (70 eyes) with a mean ± standard (SD) age of 50.2 ± 13.4 years were included, and 14 (40%) were men. The mean ± SD of the OSDI score was 44.24 ± 22.59 at baseline. Of the 35 patients, 10 (28.6%), 5 (14.3%), and 20 (57.1%) had mild, moderate, and severe ocular surface disease, respectively, according to the baseline OSDI score. Compared to baseline, the mean values of both TBUT and Schirmer I tests improved significantly in both groups (both P < 0.001). In comparing the final mean values between the 2 groups, this improvement was comparable for the Schirmer I test (P = 0.179), but TBUT in Tearlose-instilled eyes improved significantly more than in the fellow eyes (P < 0.001). Conclusions: Both Xiloial and Tearlose eye drops improved tear stability and tear production after a 2 week treatment period in eyes with dry eye disease. This improvement was comparable for tear production, but Tearlose-instilled eyes showed significantly greater improvement in tear stability. Further studies with longer follow-up and larger sample sizes could provide more reliable results as a basis for the clinical use of this TSP-containing lubricant eye drop solution in dry eye disease.

Tear Film Osmolarity, Ocular Surface Disease and Glaucoma: A Review

2019 ◽  
Vol 26 (22) ◽  
pp. 4241-4252 ◽  
Author(s):  
Paolo Fogagnolo ◽  
Giulia Torregrossa ◽  
Laura Tranchina ◽  
Antonio Ferreras ◽  
Stefano De Cillá ◽  
...  
Keyword(s):  
Side Effects ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Ocular Surface Disease ◽  
Eye Disease ◽  
The World ◽  
Iatrogenic Damage ◽  
Surgical Treatments

Glaucoma is the second leading cause of blindness in the world, affecting more than 60 million people globally. In order to reduce the progression of the disease, both medical and surgical treatments are used. Frequent side effects of both treatments include a range of modifications of the ocular surface grouped as the Ocular Surface Disease (OSD), which include Dry Eye Disease (DED). DED and other OSD negatively impact on the success of anti-glaucoma treatments and reduce the adherence to medical therapies. Tear film osmolarity (TFO) is a relatively novel test which has become a hallmark of DED. The aim of this paper was to review the association between OSD, DED and glaucoma in view of published TFO data, and to discuss future fields of research and treatments on the topic of glaucoma iatrogenic damage.

scholarly journals Diagnostic ability of maximum blink interval together with Japanese version of Ocular Surface Disease Index score for dry eye disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kunihiko Hirosawa ◽  
Takenori Inomata ◽  
Jaemyoung Sung ◽  
Masahiro Nakamura ◽  
Yuichi Okumura ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Discriminant Validity ◽  
Japanese Version ◽  
Dry Eye Disease ◽  
Disease Index ◽  
Ocular Surface Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Diagnostic Ability

Abstract Various symptoms of the dry eye disease (DED) interfere with the quality of life and reduce work productivity. Therefore, screening, prevention, and treatment of DED are important. We aimed to investigate the potential diagnostic ability of the maximum blink interval (MBI) (the length of time participants could keep their eyes open) with disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 with DED and 113 without DED) recruited between September 2017 and December 2019. Discriminant validity was assessed by comparing the non-DED and DED groups based on the MBI with a Japanese version of the Ocular Surface Disease Index (J-OSDI) and tear film breakup time (TFBUT) with J-OSDI classifications. The MBI with J-OSDI showed good discriminant validity by known-group comparisons. The positive and predictive values of MBI with J-OSDI were 96.0% (190/198 individuals) and 37.1% (62/167 individuals), respectively. The area under the receiver operating characteristic curve (AUC) of MBI with J-OSDI was 0.938 (95% confidence interval 0.904–0.971), the sensitivity was 75.4% (190/252 individuals), and the specificity was 92.9% (105/113 individuals), which are similar to the diagnostic ability of TFBUT with J-OSDI (AUC 0.954). In conclusion, MBI with J-OSDI may be a simple, non-invasive screening test for DED.

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