Faculty Opinions recommendation of Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke: subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial.

2015 ◽  
Author(s):  
Andrea Semplicini
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Subgroup Analysis ◽  
Nitric Oxide Donor

scholarly journals Opposite Reactivity of Meningeal versus Cortical Microvessels to the Nitric Oxide Donor Glyceryl Trinitrate Evaluated In Vivo with Two-Photon Imaging

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89699 ◽  
Author(s):  
Evgeny Pryazhnikov ◽  
Mikhail Kislin ◽  
Marina Tibeykina ◽  
Dmytro Toptunov ◽  
Anna Ptukha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Nitric Oxide Donor ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging

Influence of the nitric oxide donor glyceryl trinitrate on apoptotic pathways in human colon cancer cells

2002 ◽  
Vol 123 (1) ◽  
pp. 235-246 ◽  
Author(s):  
Anne Millet ◽  
Ali Bettaieb ◽  
Flore Renaud ◽  
Laurent Prevotat ◽  
Arlette Hammann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Glyceryl Trinitrate ◽  
Cancer Cells ◽  
Human Colon ◽  
Nitric Oxide Donor ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Apoptotic Pathways ◽  
Human Colon Cancer Cells

scholarly journals Glyceryl trinitrate in first-episode psychosis unmedicated with antipsychotics: A randomised controlled pilot study

2020 ◽  
Vol 34 (8) ◽  
pp. 839-847 ◽  
Author(s):  
Kate Merritt ◽  
Ana Catalan ◽  
Samuel Cowley ◽  
Arsime Demjaha ◽  
Matthew Taylor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Verbal Memory ◽  
Alternative Hypothesis ◽  
Controlled Trial ◽  
Verbal Learning ◽  
Nitric Oxide Donor ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Double Blind

Background: There is a pressing need for new classes of treatment for psychosis. A key therapeutic target for novel compounds is the NMDA receptor, which may be modulated by nitric oxide donors such as sodium nitroprusside (SNP). Recent studies of SNP in patients with psychosis have mixed results, and the drug has to be administered intravenously. Glyceryl trinitrate (GTN) is a well-established cardiovascular medicine that is also a nitric oxide donor, and can be given orally. Aims: We explored the safety and potential effects of GTN in unmedicated patients with a first episode of psychosis. Methods: This was a single-centre, randomised, double-blind, placebo-controlled trial from December 2016 to April 2019 (ClinicalTrials.gov identifier: NCT02906553). Patients received 3 × sprays of GTN or placebo for three consecutive days, and were re-assessed on Days 1, 2, 3 and 7. The primary outcome was cognition (Jumping to Conclusions task), secondary outcomes were symptoms (Positive and Negative Syndrome Scale (PANSS)), verbal memory (Hopkins Verbal Learning task), and mood (Bond–Lader Visual Analogue Scales). Results: Nineteen patients were randomised, and 13 participants were included in the analyses. Compared with placebo, GTN was well tolerated, but was not associated with significant effects on cognition, symptoms, or mood. Bayesian statistics indicate that our results were 2× more likely under the null hypothesis than the alternative hypothesis, providing anecdotal evidence that GTN does not improve psychotic symptoms. Conclusions: We found no indication of an effect of GTN on symptoms of psychosis or cognition.

Oral nitric-oxide donor glyceryl-trinitrate induces sensitization in spinal cord pain processing in migraineurs: A double-blind, placebo-controlled, cross-over study

2011 ◽  
Vol 15 (5) ◽  
pp. 482-490 ◽  
Author(s):  
Armando Perrottal ◽  
Mariano Serraol ◽  
Cristina Tassorellil ◽  
Natalia Arce-Leall ◽  
Elena Guaschinol ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Glyceryl Trinitrate ◽  
Nitric Oxide Donor ◽  
Pain Processing ◽  
Double Blind ◽  
Double Blind Placebo
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