Faculty Opinions recommendation of Cutting edge: critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses.

2017 ◽  
Author(s):  
Philippe Saas ◽  
Sylvain Perruche
Keyword(s):  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Critical Role ◽  
Cutting Edge ◽  
Antiviral Responses

scholarly journals Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses

2016 ◽  
Vol 196 (5) ◽  
pp. 2004-2009 ◽  
Author(s):  
Gagan Bajwa ◽  
Ralph J. DeBerardinis ◽  
Baomei Shao ◽  
Brian Hall ◽  
J. David Farrar ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Critical Role ◽  
Cutting Edge ◽  
Antiviral Responses

scholarly journals Essential role of IPS-1 in innate immune responses against RNA viruses

2006 ◽  
Vol 203 (7) ◽  
pp. 1795-1803 ◽  
Author(s):  
Himanshu Kumar ◽  
Taro Kawai ◽  
Hiroki Kato ◽  
Shintaro Sato ◽  
Ken Takahashi ◽  
...  
Keyword(s):  
Rna Viruses ◽  
Rna Virus ◽  
Critical Role ◽  
Nuclear Factor Κb ◽  
Type I ◽  
Innate Immune Responses ◽  
Antiviral Responses ◽  
Deficient Mice

IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses in vivo. IPS-1–deficient mice showed severe defects in both RIG-I– and Mda5-mediated induction of type I interferon and inflammatory cytokines and were susceptible to RNA virus infection. RNA virus–induced interferon regulatory factor-3 and nuclear factor κB activation was also impaired in IPS-1–deficient cells. IPS-1, however, was not essential for the responses to either DNA virus or double-stranded B-DNA. Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses.

Critical role of IL-6 in dendritic cell-induced allergic inflammation of asthma

2015 ◽  
Vol 94 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Yen-Lin Lin ◽  
Shun-Hua Chen ◽  
Jiu-Yao Wang
Keyword(s):  
Dendritic Cell ◽  
Critical Role ◽  
Allergic Inflammation

scholarly journals Cutting Edge: Critical Role of IκB Kinase α in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells

2010 ◽  
Vol 184 (7) ◽  
pp. 3341-3345 ◽  
Author(s):  
Katsuaki Hoshino ◽  
Izumi Sasaki ◽  
Takahiro Sugiyama ◽  
Takahiro Yano ◽  
Chihiro Yamazaki ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Critical Role ◽  
Cutting Edge ◽  
Type I ◽  
Type I Ifn ◽  
Iκb Kinase

scholarly journals Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure

2015 ◽  
Vol 196 (2) ◽  
pp. 553-557 ◽  
Author(s):  
Moyar Qing Ge ◽  
Blerina Kokalari ◽  
Cameron H. Flayer ◽  
Sarah S. Killingbeck ◽  
Imre G. Redai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Dendritic Cell ◽  
Nk Cells ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Ozone Exposure ◽  
Surfactant Protein D ◽  
Lymph Node Homing

scholarly journals Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease

2017 ◽  
Vol 199 (8) ◽  
pp. 2624-2629 ◽  
Author(s):  
Ryuta Kamekura ◽  
Kenichi Takano ◽  
Motohisa Yamamoto ◽  
Koji Kawata ◽  
Katsunori Shigehara ◽  
...  
Keyword(s):  
Critical Role ◽  
Cutting Edge ◽  
T Follicular Helper Cells ◽  
Related Disease ◽  
Helper Cells ◽  
Igg4 Related Disease ◽  
Follicular Helper

scholarly journals Cutting Edge: Critical Role of Intracellular Osteopontin in Antifungal Innate Immune Responses

2010 ◽  
Vol 186 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Makoto Inoue ◽  
Yasuhiro Moriwaki ◽  
Tomohiro Arikawa ◽  
Yu-Hsun Chen ◽  
Young Joo Oh ◽  
...  
Keyword(s):  
Immune Responses ◽  
Critical Role ◽  
Innate Immune ◽  
Cutting Edge ◽  
Innate Immune Responses

scholarly journals Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions

2001 ◽  
Vol 166 (6) ◽  
pp. 3659-3662 ◽  
Author(s):  
Chen Dong ◽  
Ulla-Angela Temann ◽  
Richard A. Flavell
Keyword(s):  
Germinal Center ◽  
Critical Role ◽  
Cutting Edge ◽  
Inducible Costimulator

scholarly journals The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

2008 ◽  
Vol 205 (10) ◽  
pp. 2419-2435 ◽  
Author(s):  
Hailong Guo ◽  
Asanga Samarakoon ◽  
Bart Vanhaesebroeck ◽  
Subramaniam Malarkannan
Keyword(s):  
Nk Cells ◽  
Nk Cell ◽  
Critical Role ◽  
Cell Receptor ◽  
Cell Development ◽  
Effector Functions ◽  
Antiviral Responses

Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in regulating B cell receptor– and T cell receptor–mediated signaling. However, their role in natural killer (NK) cell development and functions is not well understood. Using mice expressing p110δD910A, a catalytically inactive p110δ, we show that these mice had reduced NK cellularity, defective Ly49C and Ly49I NK subset maturation, and decreased CD27High NK numbers. p110δ inactivation marginally impaired NK-mediated cytotoxicity against tumor cells in vitro and in vivo. However, NKG2D, Ly49D, and NK1.1 receptor–mediated cytokine and chemokine generation by NK cells was severely affected in these mice. Further, p110δD910A/D910A NK cell–mediated antiviral responses through natural cytotoxicity receptor 1 were reduced. Analysis of signaling events demonstrates that p110δD910A/D910A NK cells had a reduced c-Jun N-terminal kinase 1/2 phosphorylation in response to NKG2D-mediated activation. These results reveal a previously unrecognized role of PI3K-p110δ in NK cell development and effector functions.

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