Faculty Opinions recommendation of Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten Challenge.

2018 ◽  
Author(s):  
Giovanni Barbara
Keyword(s):  
Gastrointestinal Symptoms ◽  
Gluten Sensitivity ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Non-celiac wheat sensitivity: a search for the pathogenesis of a self-reported condition

2019 ◽  
Vol 13 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Pasquale Mansueto ◽  
Maurizio Soresi ◽  
Rosario Iacobucci ◽  
Francesco La Blasca ◽  
Giulia Romano ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Wheat Allergy ◽  
Allergy Diagnosis ◽  
Double Blind ◽  
Innate And Adaptive Immunity ◽  
Double Blind Placebo ◽  
Wheat Sensitivity

A significant percentage of the general population reports gastrointestinal and non-gastrointestinal symptoms caused by wheat and/or gluten ingestion, even though they do not suffer from celiac disease (CD) or wheat allergy (WS), because they test negative both for CD-specific serology and histopathology. All patients report improvement of symptoms on a gluten-free diet. This clinical condition has been named non-celiac gluten sensitivity (NCGS). The objective of this paper was to review some studies regarding the pathogenesis of NCGS to summarize the current hypotheses about the mechanisms, which can lead to NCGS. Particular attention was given to the immunologic and the malabsorptive hypotheses. We reviewed data of our previous studies involving patients diagnosed with NCWS by means of double-blind placebo-controlled wheat challenge. The data indicating a possible wheat allergy diagnosis were examined and other data in the literature were reviewed; we also reviewed the putative role of fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAPs) and of α-amylasetrypsin inhibitors (ATIs) proteins in the NCGS pathogenesis. NCGS pathogenesis has been attributed to very different mechanisms, among others: i) activation of innate and adaptive immunity (the immune/allergic mechanisms) induced by gluten or the non-gluten ATI family; ii) incomplete digestion and/or absorption of FODMAPs (the intolerance mechanisms); and iii) psychological effect.We suggest that NCGS is a heterogeneous condition, which includes different subgroups of patients who have different pathogenic mechanisms: strong data suggest a direct pathogenic immunogenic/inflammatory role of wheat-cereal proteins (not only gluten) in a subgroup, probably the largest, of these patients.

scholarly journals Prevalence of Non-Celiac Gluten Sensitivity in Patients with Refractory Functional Dyspepsia: a Randomized Double-blind Placebo Controlled Trial

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Bijan Shahbazkhani ◽  
Mohammad M. Fanaeian ◽  
Mohammad J. Farahvash ◽  
Najmeh Aletaha ◽  
Foroogh Alborzi ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Controlled Trial ◽  
Gluten Sensitivity ◽  
Double Blind ◽  
Double Blind Placebo

Diagnosis of non-coeliac gluten sensitivity: First double blind placebo controlled cross over trial in pediatrics

2015 ◽  
Vol 47 ◽  
pp. e269 ◽  
Author(s):  
A. Gentile ◽  
F. Cristofori ◽  
L. Verzillo ◽  
F. Arezzo ◽  
C. Polloni ◽  
...  
Keyword(s):  
Gluten Sensitivity ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effectiveness ofLactobacillus helveticusandLactobacillus rhamnosusfor the management of antibiotic-associated diarrhoea in healthy adults: a randomised, double-blind, placebo-controlled trial

2016 ◽  
Vol 116 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Malkanthi Evans ◽  
Ryan P. Salewski ◽  
Mary C. Christman ◽  
Stephanie-Anne Girard ◽  
Thomas A. Tompkins
Keyword(s):  
Rating Scale ◽  
Gastrointestinal Symptoms ◽  
Healthy Adults ◽  
Lactobacillus Helveticus ◽  
Primary Study ◽  
Gastrointestinal Microbiota ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Probiotic Intervention ◽  
Antibiotic Associated Diarrhoea

AbstractBroad-spectrum antibiotic use can disrupt the gastrointestinal microbiota resulting in diarrhoea. Probiotics may be beneficial in managing this type of diarrhoea. The aim of this 10-week randomised, double-blind, placebo-controlled, parallel study was to investigate the effect ofLactobacillus helveticusR0052 andLactobacillus rhamnosusR0011 supplementation on antibiotic-associated diarrhoea in healthy adults. Subjects were randomised to receive 1 week of amoxicillin–clavulanic acid (875 mg/125 mg) once per day, plus a daily dose of 8×109colony-forming units of a multi-strain probiotic (n80) or placebo (n80). The probiotic or placebo intervention was maintained for 1 week after completion of the antibiotic. Primary study outcomes of consistency and frequency of bowel movements were not significantly different between the probiotic and placebo groups. The secondary outcomes of diarrhoea-like defecations, Gastrointestinal Symptoms Rating Scale scores, safety parameters and adverse events were not significantly different between the probiotic intervention and the placebo. Apost hocanalysis on the duration of diarrhoea-like defecations showed that probiotic intervention reduced the length of these events by 1 full day (probiotic, 2·70(sem0·36) d; placebo, 3·71 (sem0·36) d;P=0·037; effect size=0·52). In conclusion, this study provides novel evidence thatL. helveticusR0052 andL. rhamnosusR0011 supplementation significantly reduced the duration of diarrhoea-like defecations in healthy adults receiving antibiotics.

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