Faculty Opinions recommendation of Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology.

2016 ◽  
Author(s):  
Ram Samudrala ◽  
Jim Schuler
Keyword(s):  
Virus Replication ◽  
Ebola Virus ◽  
Drug Repurposing ◽  
Structural Systems ◽  
Systems Pharmacology

scholarly journals Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Zheng Zhao ◽  
Che Martin ◽  
Raymond Fan ◽  
Philip E. Bourne ◽  
Lei Xie
Keyword(s):  
Virus Replication ◽  
Ebola Virus ◽  
Drug Repurposing ◽  
Structural Systems ◽  
Systems Pharmacology

Ebola virus replication is regulated by the phosphorylation of viral protein VP35

2020 ◽  
Vol 521 (3) ◽  
pp. 687-692 ◽  
Author(s):  
Lin Zhu ◽  
Ting Gao ◽  
Weihong Yang ◽  
Yaoning Liu ◽  
Xuan Liu ◽  
...  
Keyword(s):  
Virus Replication ◽  
Viral Protein ◽  
Ebola Virus

scholarly journals Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

2018 ◽  
Vol 158 ◽  
pp. 288-302 ◽  
Author(s):  
Priya Luthra ◽  
Jacinth Naidoo ◽  
Colette A. Pietzsch ◽  
Sampriti De ◽  
Sudip Khadka ◽  
...  
Keyword(s):  
Immune Responses ◽  
Virus Replication ◽  
Ebola Virus ◽  
Innate Immune ◽  
Pyrimidine Biosynthesis ◽  
Innate Immune Responses

scholarly journals Inhibition of heat-shock protein 90 reduces Ebola virus replication

2010 ◽  
Vol 87 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Darci R. Smith ◽  
Sarah McCarthy ◽  
Andrew Chrovian ◽  
Gene Olinger ◽  
Andrea Stossel ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Virus Replication ◽  
Ebola Virus ◽  
Heat Shock Protein 90

scholarly journals Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors

Cell Reports ◽  
2018 ◽  
Vol 22 (5) ◽  
pp. 1159-1168 ◽  
Author(s):  
Shannon L.M. Whitmer ◽  
Jason T. Ladner ◽  
Michael R. Wiley ◽  
Ketan Patel ◽  
Gytis Dudas ◽  
...  
Keyword(s):  
Virus Replication ◽  
Ebola Virus ◽  
Evolutionary Rates

scholarly journals Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment

2016 ◽  
Vol 214 (suppl 3) ◽  
pp. S308-S318 ◽  
Author(s):  
Jessica R. Spengler ◽  
Kerry J. Lavender ◽  
Cynthia Martellaro ◽  
Aaron Carmody ◽  
Andreas Kurth ◽  
...  
Keyword(s):  
Virus Replication ◽  
Lymphoid Cell ◽  
Ebola Virus ◽  
Cell Engraftment

scholarly journals Protein Phosphatase 1–Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

2018 ◽  
Vol 218 (suppl_5) ◽  
pp. S627-S635 ◽  
Author(s):  
Tatiana Ammosova ◽  
Colette A Pietzsch ◽  
Yasemin Saygideğer ◽  
Andrey Ilatovsky ◽  
Xionghao Lin ◽  
...  
Keyword(s):  
Virus Replication ◽  
Small Molecule ◽  
Protein Phosphatase ◽  
Ebola Virus ◽  
Protein Phosphatase 1

scholarly journals The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication

2013 ◽  
Vol 87 (24) ◽  
pp. 13795-13802 ◽  
Author(s):  
L. Hill-Batorski ◽  
P. Halfmann ◽  
G. Neumann ◽  
Y. Kawaoka
Keyword(s):  
Virus Replication ◽  
Heme Oxygenase ◽  
Ebola Virus ◽  
Heme Oxygenase 1

scholarly journals DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Naiem T. Issa ◽  
Jordan Kruger ◽  
Henri Wathieu ◽  
Rajarajan Raja ◽  
Stephen W. Byers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drug Repurposing ◽  
Systems Pharmacology ◽  
Computational Platform
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