Faculty Opinions recommendation of Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic overview of systematic reviews.

Author(s):  
Harold Nelson
Author(s):  
Felix Asamoah ◽  
Artemisia Kakourou ◽  
Sangeeta Dhami ◽  
Susanne Lau ◽  
Ioana Agache ◽  
...  

2020 ◽  
pp. 152483802096734
Author(s):  
Karen R. Quail ◽  
Catherine L. Ward

Violence against children is a widespread problem with devastating consequences, and corporal punishment is a risk factor for more serious forms of physical abuse. One reason for the persistence of corporal punishment may be the lack of awareness of positive disciplinary alternatives. Nonviolent options offered to caregivers and teachers must be effective in addressing challenging behavior, or they may be rejected in favor of a return to physical punishment. There is an urgent need to determine which discipline options are evidence-supported and what that evidence says so that robust alternatives to corporal punishment can be made available. The primary objective of this research was to find, and explore the state of the science on, individual nonviolent interventions for challenging behavior, in so doing forming a “tool kit” for use by caregivers and teachers. A systematic overview of systematic reviews was conducted. Included systematic reviews were peer-reviewed and published in English between 1999 and 2018. Screening, quality assessment using AMSTAR, and data extraction were performed independently by two reviewers. A total of 223 reviews were included, covering data from 3,921 primary studies. A wide range of evidence-supported interventions exist, many of which have been found effective with severely challenging behavior. Important positive outcomes shown suggest that the use of these tools should be promoted not only for the prevention of violence but also for optimum child development. More research is needed on the use of these methods in home situations and on de-escalation skills.


2020 ◽  
Vol 9 (8) ◽  
pp. 527-536
Author(s):  
Mohammed Ahmed Abdelaal ◽  
Dina Abushanab ◽  
Daoud Al-Badriyeh

Aim: To conduct a systematic overview of systematic reviews (SRs) and randomized clinical trials (RCTs) on surfactant therapy in neonatal meconium aspiration syndrome. Methods: We searched EMBASE, PROQUEST and PubMed to summarize the different effects of surfactant lung lavage and bolus surfactant therapies in neonates with meconium aspiration syndrome. Results: With a total of 1377 patients, three SRs and two RCTs were included in analysis. Surfactant effectiveness was concluded by low-quality SRs, with high risk of bias, which was contradicted by high-quality SRs, with low risk of bias. In SRs, the surfactant lung lavage reduced mortality, need for extracorporeal membrane oxygenation and hospitalization, while the bolus surfactant did not. In recent high-quality RCTs, however, the two modalities did not significantly differ. Conclusion: The evidence on surfactant effectiveness and its method of administration is sparse and inconsistent.


2020 ◽  
Vol 30 (2) ◽  
pp. 167-193 ◽  
Author(s):  
Hanna Malmberg Gavelin ◽  
Amit Lampit ◽  
Harry Hallock ◽  
Julieta Sabatés ◽  
Alex Bahar-Fuchs

Author(s):  
Felix Walther ◽  
Denise Kuester ◽  
Jochen Schmitt

Quality of care and the increasing strategies to its promotion, especially in inpatient settings, led to the question which quality-interventions work best and which do not. The aim was to summarize and critically appraise the evidence on the effects of structure- and/or process-related quality-interventions on patient outcome in predominantly controlled and inpatient settings. A systematic overview of systematic reviews after electronic searches in Medline, Embase, Cinahl, and PsycINFO, supplemented by hand search and expert survey, was conducted. From a total of 1559 identified records, 37 reviews fulfilled the inclusion criteria. 26 reviews assessed process-related quality-interventions, 6 structure-related quality-interventions, and 5 combined structure- and process-related quality-interventions. In all, 19 reviews reported pooled effect estimates (meta-analysis). Based on the evidence of this systematic overview, stroke units and pathways can be recommended. Although patient-relevant improvements for interprofessional approaches and discharge planning have been reported, pooled effect estimated evidence are currently missing for these and other quality-interventions.


2019 ◽  
Author(s):  
Hanna Malmberg Gavelin ◽  
Amit Lampit ◽  
Harry Hallock ◽  
Julieta Sabates ◽  
Alex Bahar-Fuchs

Cognition-oriented treatments (COTs) – commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation – are promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of COTs on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by AMSTAR 2. We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were “moderate” for 9 (20%), “low” for 13 (28%) and “critically low” for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (Hedge’s g 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (Hedge’s g 0.40, range 0.32-0.60, five reviews), and dementia (Hedge’s g 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (Hedge’s g 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of COTs improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards.PROSPERO registration number: CRD42018084490.Gavelin, H.M., Lampit, A., Hallock, H. et al. Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews. Neuropsychol Rev (2020). https://doi.org/10.1007/s11065-020-09434-8


2006 ◽  
Vol 14 (7S_Part_31) ◽  
pp. P1627-P1628 ◽  
Author(s):  
Hanna Malmberg Gavelin ◽  
Amit Lampit ◽  
Alex Bahar-Fuchs

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