Faculty Opinions recommendation of Local immune response to food antigens drives meal-induced abdominal pain.

The most common clinical manifestations of coronavirus SARS-CoV-2 (COVID-19) include fever, cough, dyspnea, sore throat, muscle or bone aches, chills, and headache. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Although is not clear the mechanisms responsible for the development of diarrhea in COVID-19, the current hypothesis is that the direct viral infection on the intestinal tissue and local immune response to the virus may be involved. Additionally, after gastrointestinal SARS-CoV-2 infection some patients may develop alterations in the gastrointestinal microbiota. In this review we outlined the important GI manifestations of COVID-19 and discussed the possible mechanisms and aspects relating to their diagnosis and management.

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Local Immune Response in Skin of Generalized Vitiligo Patients

Laboratory Investigation ◽

10.1038/labinvest.3780138 ◽

2000 ◽

Vol 80 (8) ◽

pp. 1299-1309 ◽

Cited By ~ 159

Author(s):

René van den Wijngaard ◽

Anna Wankowicz-Kalinska ◽

Caroline Le Poole ◽

Bert Tigges ◽

Wiete Westerhof ◽

...

Keyword(s):

Immune Response ◽

Local Immune Response

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PS02.176: LINE-1 METHYLATION LEVEL AND LOCAL IMMUNE RESPONSE IN ESOPHAGEAL CANCER

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.176 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 172-172

Author(s):

Yoshifumi Baba ◽

Taisuke Yagi ◽

Yuki Kiyozumi ◽

Yukiharu Hiyoshi ◽

Masaaki Iwatsuki ◽

...

Keyword(s):

Dna Methylation ◽

Immune Response ◽

Esophageal Cancer ◽

Methylation Level ◽

Cpg Island ◽

Surrogate Marker ◽

Esophageal Tumor ◽

Local Immune Response ◽

Dna Hypomethylation ◽

Response Status

Abstract Background In cancer cells, DNA methylation may be altered in two principle ways; global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Since Long interspersed element-1 (LINE-1 or L1; a repetitive DNA retrotransposon) constitutes a substantial portion (approximately 17%) of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation. In previous studies, we demonstrated that LINE-1 hypomethylation was strongly associated with a poor prognosis in esophageal cancer, supporting its potential role as a prognostic marker (Ann Surg 2012). We also found that LINE-1-hypomethylated tumors showed highly frequent genomic gains at various loci containing candidate oncogenes such as CDK6 (Clin Cancer Res 2014). Given that immunotherapy, as represented by PD-1/PD-L1-targeting antibodies, has increasingly gained attention as a novel treatment strategy for esophageal cancer, better understanding of local immune response status in esophageal cancer is important. The aim of this study is to evaluate the relationship between LINE-1 methylation level and local immune response in esophageal cancer. Methods Using a non-biased database of 305 curatively resected esophageal cancers, we evaluated PD-L1 expression and TIL status (CD8 expression) by immunohistochemical analysis (Ann Surg 2017). Results TIL positivity was significantly correlated with longer overall survival (log-rank P < 0.0001). TIL-negative cases demonstrated significantly lower LINE-1 methylation level compared with TIL-positive cases (P = 0.012). This finding certainly supports that LINE-1 methylation level may influence the local immune response status. Conclusion PD-L1 expression was not related with LINE-1 methylation level. Further investigations in this field would provide deeper insights into esophageal tumor immunology and assist the development of new therapeutic strategies against esophageal cancer. Disclosure All authors have declared no conflicts of interest.

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Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2–3 regression

Gynecologic Oncology ◽

10.1016/j.ygyno.2012.09.010 ◽

2012 ◽

Vol 127 (3) ◽

pp. 489-494 ◽

Cited By ~ 19

Author(s):

Ane Cecilie Munk ◽

Einar Gudlaugsson ◽

Irene Tveiteras Ovestad ◽

Kjell Lovslett ◽

Bent Fiane ◽

...

Keyword(s):

Immune Response ◽

Condom Use ◽

Cervical Intraepithelial Neoplasia ◽

Intraepithelial Neoplasia ◽

Local Immune Response

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The local immune response in ulcerative lesions of Buruli disease

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.2006.03020.x ◽

2006 ◽

Vol 143 (3) ◽

pp. 445-451 ◽

Cited By ~ 51

Author(s):

A. E. Kiszewski ◽

E. Becerril ◽

L. D. Aguilar ◽

I. T. A. Kader ◽

W. Myers ◽

...

Keyword(s):

Immune Response ◽

Local Immune Response ◽

Ulcerative Lesions

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RESPIRATORY SYNCYTIAL VIRUS LUNG INFECTION IN INFANTS: IMMUNOREGULATORY ROLE OF INFECTED ALVEOLAR MACROPHAGES

PEDIATRICS ◽

10.1542/peds.96.2.391 ◽

1995 ◽

Vol 96 (2) ◽

pp. 391-391

Author(s):

Leon S. Greos

Keyword(s):

Immune Response ◽

Respiratory Syncytial Virus ◽

Lung Injury ◽

Alveolar Macrophages ◽

Lung Infection ◽

Local Immune Response ◽

Rsv Infection ◽

Syncytial Virus

Alveolar macrophages are infected by RSV in vivo and coexpress potent immunomodulatory molecules that potentially regulate local immune response or lung injury caused by RSV infection.

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