The gastrointestinal tract and COVID-19. Observations after the year of the pandemic. Part 1. Patients with diseases of the upper gastrointestinal tract

2021 ◽  
Vol 14 (3) ◽  
pp. 225-231
Author(s):  
Anita Gąsiorowska
Keyword(s):  
Immune Response ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Viral Infection ◽  
Clinical Manifestations ◽  
Local Immune Response ◽  
Gastrointestinal Microbiota ◽  
Gastrointestinal Infections ◽  
Intestinal Tissue ◽  
Upper Gastrointestinal

The most common clinical manifestations of coronavirus SARS-CoV-2 (COVID-19) include fever, cough, dyspnea, sore throat, muscle or bone aches, chills, and headache. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Although is not clear the mechanisms responsible for the development of diarrhea in COVID-19, the current hypothesis is that the direct viral infection on the intestinal tissue and local immune response to the virus may be involved. Additionally, after gastrointestinal SARS-CoV-2 infection some patients may develop alterations in the gastrointestinal microbiota. In this review we outlined the important GI manifestations of COVID-19 and discussed the possible mechanisms and aspects relating to their diagnosis and management.

scholarly journals Síndrome de Rapunzel. Reporte de un caso

2020 ◽  
Vol 50 (3) ◽  
Author(s):  
Vanessa Durán Becerra ◽  
Laura Tatiana Padilla Pinzón ◽  
Jean Andre Pulido Segura ◽  
Luis Felipe Cabrera Vargas ◽  
Mauricio Pedraza Ciro ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Gold Standard ◽  
Gastrointestinal Endoscopy ◽  
Clinical Manifestations ◽  
Exploratory Laparotomy ◽  
Upper Gastrointestinal Endoscopy ◽  
Rapunzel Syndrome ◽  
Difficult Diagnosis ◽  
Upper Gastrointestinal

Bezoars are accumulations of non-digestible material in the gastrointestinal tract; classified according to the material that it is composed. They are called trichobezoars to those who are formed by the hair, and when are extended to the gastric chamber are called Rapunzel syndrome. It presents mainly in teenagers associated with psychiatric disorders. It has different clinical manifestations and the upper gastrointestinal endoscopy is the gold standard for its diagnosis. We present a case of a Rapunzel Syndrome in an 18 years old patient who was admitted due to abdominal pain, emesis and absence of stools. The initial diagnosis was a difficult diagnosis because of an intestinal obstruction. By this reason it was decided to perform an exploratory laparotomy where it was found a trichobezoar which was extended over the pylorus. According to literature, Laparotomy is the most successful procedure for the resolution of this disease.

scholarly journals The interplay between local immune response and Epstein–Barr virus-infected tonsillar cells could lead to viral infection control

2018 ◽  
Vol 207 (5-6) ◽  
pp. 319-327 ◽  
Author(s):  
Aldana G. Vistarop ◽  
Melina Cohen ◽  
Fuad Huaman ◽  
Lucia Irazu ◽  
Marcelo Rodriguez ◽  
...  
Keyword(s):  
Immune Response ◽  
Infection Control ◽  
Viral Infection ◽  
Epstein Barr Virus ◽  
Local Immune Response ◽  
Barr Virus ◽  
Epstein Barr ◽  
Tonsillar Cells

scholarly journals Sa1265 CLINICAL MANIFESTATIONS OF T-CELL LEUKEMIA/LYMPHOMA INFILTRATION OF UPPER GASTROINTESTINAL TRACT LESIONS

2018 ◽  
Vol 87 (6) ◽  
pp. AB187
Author(s):  
Tadashi Miike ◽  
Naoki Ichinari ◽  
Emi Yonezawa ◽  
Tomoya Hirata ◽  
Takaho Noda ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Clinical Manifestations ◽  
Upper Gastrointestinal Tract ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Upper Gastrointestinal

Tinjauan Biomolekuler Dan Klinis Ocular Covid-19

2020 ◽  
Vol 10 (2) ◽  
pp. 53-66
Author(s):  
Lylys Surjani ◽  
◽  
Jekson Siahaan ◽  
Keyword(s):  
Immune Response ◽  
Viral Infection ◽  
Clinical Manifestation ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Clinical Findings ◽  
Conjunctival Epithelium ◽  
Cytokine Storm ◽  
Important Thing ◽  
Entry Points

The clinical manifestations of Covid -19 are not only in the airway but are also found in eyes with conjunctival epithelium and ACE-2 receptors as their entry points. The most common clinical manifestation is conjunctivitis, therefore it is not easy to make a diagnosis if it relies on clinical findings because it is similar to a common viral infection. This infection has clinical manifestations in the airway that triggers the immune response leading to a cytokine storm with fatal consequences. There is no specific treatment up to this time. The most important thing is to prevent infection.

Duodenal Obstruction from Isolated Breast Cancer Metastasis a Case Report

2002 ◽  
Vol 88 (5) ◽  
pp. 427-429 ◽  
Author(s):  
Michele Lottini ◽  
Alessandro Neri ◽  
Giuseppe Vuolo ◽  
Michele Testa ◽  
Loreta Pergola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gastrointestinal Tract ◽  
Intestinal Obstruction ◽  
Cancer Metastasis ◽  
Clinical Manifestations ◽  
Breast Cancer Metastasis ◽  
Metastatic Spread ◽  
Systemic Spread ◽  
Metastatic Involvement ◽  
Upper Gastrointestinal

Metastatic involvement of the upper gastrointestinal tract from breast cancer has been reported in autopsy series as occurring in more than 15% of patients, usually associated with extensive systemic spread; clinical manifestations from such metastases have been described in less than 1% of cases. Lobular infiltrating carcinoma seems to have a different metastatic pattern than the ductal type, with an apparent predilection for the gastrointestinal tract. Metastatic presentation as an isolated intestinal obstruction without other signs of metastatic spread is extremely rare. We present a case of isolated duodenal metastasis from breast cancer, associated with intestinal obstruction, as the first sign of metastatic spread.

scholarly journals Inflammatory fibroid polyp: an unusual cause of abdominal pain in the upper gastrointestinal tract A case report

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Huan Wang ◽  
Tiejun Zhou ◽  
Cuiwei Zhang ◽  
Hao Li ◽  
Muhan Lü
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Endoscopic Ultrasound ◽  
Epithelial Tissue ◽  
Benign Neoplasms ◽  
Inflammatory Fibroid Polyp ◽  
Common Location ◽  
Hypoechoic Mass ◽  
Fibroid Polyp ◽  
Upper Gastrointestinal

AbstractInflammatory fibroid polyps (IFPs) tend to occur in the gastrointestinal tract, and they are rare and benign neoplasms. In general, IFPs often come from epithelial tissue. The gastric antrum is the most common location. Endoscopic ultrasound (EUS) often shows a predominantly hypoechoic mass with well-defined borders originating from the submucosal area. Here, we report the case of a 46-year-old woman with abdominal pain who underwent computed tomography (CT), endoscopic ultrasound and endoscopic submucosal dissection (ESD) of resected specimens; the diagnosis was ultimately an inflammatory fibroid polyp. She is currently in clinical remission.

scholarly journals A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract

2020 ◽  
Vol 17 (11) ◽  
pp. 1119-1125 ◽  
Author(s):  
Fengyu Hu ◽  
Fengjuan Chen ◽  
Zhihua Ou ◽  
Qinghong Fan ◽  
Xinghua Tan ◽  
...  
Keyword(s):  
Immune Response ◽  
Gastrointestinal Tract ◽  
Receptor Binding ◽  
Humoral Immune Response ◽  
Clinical Manifestations ◽  
Viral Persistence ◽  
Binding Domain ◽  
Health Concern ◽  
Receptor Binding Domain ◽  
Humoral Immune

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data and clinical manifestations of 289 domestic Chinese COVID-19 patients and found that 21 individuals (7.3%) were readmitted for hospitalization after detection of SARS-CoV-2 after discharge. First, we experimentally confirmed that the virus was involved in the initial infection and was not a secondary infection. In positive retests, the virus was usually found in anal samples (15 of 21, 71.4%). Through analysis of the intracellular viral subgenomic messenger RNA (sgmRNA), we verified that positive retest patients had active viral replication in their gastrointestinal tracts (3 of 16 patients, 18.7%) but not in their respiratory tracts. Then, we found that viral persistence was not associated with high viral titers, delayed viral clearance, old age, or more severe clinical symptoms during the first hospitalization. In contrast, viral rebound was associated with significantly lower levels of and slower generation of viral receptor-binding domain (RBD)-specific IgA and IgG antibodies. Our study demonstrated that the positive retest patients failed to create a robust protective humoral immune response, which might result in SARS-CoV-2 persistence in the gastrointestinal tract and possibly in active viral shedding. Further exploration of the mechanism underlying the rebound in SARS-CoV-2 in this population will be crucial for preventing virus spread and developing effective vaccines.

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