Faculty Opinions recommendation of Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.740937482.793589840 ◽

2021 ◽

Author(s):

Robert Peoples

Keyword(s):

Nmda Receptors ◽

Allosteric Modulator ◽

Pharmacological Characterization ◽

Negative Allosteric Modulator

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Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792

Neuropharmacology ◽

10.1016/j.neuropharm.2021.108818 ◽

2021 ◽

Vol 201 ◽

pp. 108818

Author(s):

Kiran Sapkota ◽

Erica S. Burnell ◽

Mark W. Irvine ◽

Guangyu Fang ◽

Dinesh Y. Gawande ◽

...

Keyword(s):

Nmda Receptors ◽

Allosteric Modulator ◽

Pharmacological Characterization ◽

Negative Allosteric Modulator

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Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on l-DOPA-induced dyskinesia

Journal of Neural Transmission ◽

10.1007/s00702-010-0526-0 ◽

2010 ◽

Vol 118 (12) ◽

pp. 1703-1716 ◽

Author(s):

Andrzej Dekundy ◽

Andreas Gravius ◽

Mirko Hechenberger ◽

Małgorzata Pietraszek ◽

Jens Nagel ◽

...

Keyword(s):

Glutamate Receptors ◽

Metabotropic Glutamate Receptors ◽

Allosteric Modulator ◽

Pharmacological Characterization ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2017.05.017 ◽

2017 ◽

Vol 123 ◽

pp. 322-331 ◽

Author(s):

Brice Mullier ◽

Christian Wolff ◽

Zara Amanda Sands ◽

Philippe Ghisdal ◽

Pierandrea Muglia ◽

...

Keyword(s):

Nmda Receptors ◽

Allosteric Modulator ◽

Gain Of Function ◽

Negative Allosteric Modulator

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Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01234 ◽

2019 ◽

Vol 62 (19) ◽

pp. 8711-8732 ◽

Author(s):

Junliang Hao ◽

James P. Beck ◽

John M. Schaus ◽

Joseph H. Krushinski ◽

Qi Chen ◽

...

Keyword(s):

Dopamine D1 Receptor ◽

D1 Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Pharmacological Characterization ◽

Subtype Selective

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In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator

European Journal of Pharmacology ◽

10.1016/j.ejphar.2016.08.032 ◽

2016 ◽

Vol 791 ◽

pp. 115-123 ◽

Author(s):

Alessandra Porcu ◽

Carla Lobina ◽

Daniela Giunta ◽

Maurizio Solinas ◽

Claudia Mugnaini ◽

...

Keyword(s):

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Pharmacological Characterization

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P2-065: IN VITRO PHARMACOLOGICAL CHARACTERIZATION OF S68890, AN ALLOSTERIC MODULATOR OF ALPHA7 NICOTINIC RECEPTORS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.2472 ◽

2019 ◽

Vol 15 ◽

pp. P595-P596

Author(s):

Laurence Danober ◽

Kumiko Kambara ◽

Sonia Bertrand ◽

Daniel Bertrand ◽

Alain Benoist ◽

...

Keyword(s):

Nicotinic Receptors ◽

Allosteric Modulator ◽

Pharmacological Characterization

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In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.109.151886 ◽

2009 ◽

Vol 330 (1) ◽

pp. 257-267 ◽

Author(s):

John Malysz ◽

Jens Halvard Grønlien ◽

David J. Anderson ◽

Monika Håkerud ◽

Kirsten Thorin-Hagene ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulator ◽

Pharmacological Profile ◽

Pharmacological Characterization ◽

Neuronal Acetylcholine Receptor

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P2-311: In vitro characterization of s44858: A positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda receptors antagonist

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.853 ◽

2015 ◽

Vol 11 (7S_Part_13) ◽

pp. P612-P613

Author(s):

Laurence Danober ◽

Jean-Yves Thomas ◽

Sylvie Challal ◽

Nathalie Rogez ◽

Karine Albinet ◽

...

Keyword(s):

Nmda Receptors ◽

Ampa Receptors ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

In Vitro Characterization

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Pharmacological Characterization of the Allosteric Modulator Desformylflustrabromine and Its Interaction with α4β2 Neuronal Nicotinic Acetylcholine Receptor Orthosteric Ligands

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167684 ◽

2010 ◽

Vol 334 (3) ◽

pp. 917-926 ◽

Author(s):

Maegan M. Weltzin ◽

Marvin K. Schulte

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Allosteric Modulator ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine ◽

Orthosteric Ligands

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Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.117.242784 ◽

2017 ◽

Vol 363 (3) ◽

pp. 377-393 ◽

Author(s):

Linda J. Bristow ◽

Jyoti Gulia ◽

Michael R. Weed ◽

Bettadapura N. Srikumar ◽

Yu-Wen Li ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Allosteric Modulator ◽

Major Depressive ◽

Negative Allosteric Modulator

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