Faculty Opinions recommendation of Global analysis of nascent RNA reveals transcriptional pausing in terminal exons.

2011 ◽  
Author(s):  
Andrea Barta
Keyword(s):  
Global Analysis ◽  
Transcriptional Pausing ◽  
Nascent Rna

scholarly journals Global Analysis of Nascent RNA Reveals Transcriptional Pausing in Terminal Exons

2010 ◽  
Vol 40 (4) ◽  
pp. 571-581 ◽  
Author(s):  
Fernando Carrillo Oesterreich ◽  
Stephan Preibisch ◽  
Karla M. Neugebauer
Keyword(s):  
Global Analysis ◽  
Transcriptional Pausing ◽  
Nascent Rna

Transcriptional Pausing in Vivo: A Nascent RNA Hairpin Restricts Lateral Movements of RNA Polymerase in Both Forward and Reverse Directions

2005 ◽  
Vol 351 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Francine Toulmé ◽  
Christine Mosrin-Huaman ◽  
Irina Artsimovitch ◽  
A. Rachid Rahmouni
Keyword(s):  
Rna Polymerase ◽  
Transcriptional Pausing ◽  
Nascent Rna ◽  
Rna Hairpin

scholarly journals The elemental mechanism of transcriptional pausing

2018 ◽  
Author(s):  
Jason Saba ◽  
Xien Chua ◽  
Tatiana V. Mishanina ◽  
Dhananjaya Nayak ◽  
Tricia A. Windgassen ◽  
...  
Keyword(s):  
Base Pair ◽  
Rna Polymerases ◽  
Rna Hairpins ◽  
Rna Biogenesis ◽  
Transcriptional Pausing ◽  
Nascent Rna ◽  
Mechanistic Basis ◽  
Fundamental Mechanism

ABSTRACTTranscriptional pausing underpins regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise. Although the structural foundations of pauses prolonged by backtracking or nascent RNA hairpins are recognized, the fundamental mechanism of the elemental pause is less well-defined. Here we report a mechanistic dissection that establishes the elemental pause signal (i) is multipartite; (ii) causes a modest conformational shift that puts RNAP in an off-pathway state in which template base loading but not RNA translocation is inhibited; and (iii) can easily enter pretranslocated and one-base-pair backtracked states despite principally occupying the half-translocated state observed in cryo-EM structures of paused RNAPs. Our findings provide a mechanistic basis for the elemental pause and a framework to understand how pausing is modulated by sequence, cellular conditions, and regulators.

scholarly journals Transcriptional Pausing at +62 of the HIV-1 Nascent RNA Modulates Formation of the TAR RNA Structure

1998 ◽  
Vol 1 (7) ◽  
pp. 1033-1042 ◽  
Author(s):  
Murali Palangat ◽  
Timothy I. Meier ◽  
Richard G. Keene ◽  
Robert Landick
Keyword(s):  
Rna Structure ◽  
Transcriptional Pausing ◽  
Tar Rna ◽  
Nascent Rna ◽  
Hiv 1

scholarly journals The elemental mechanism of transcriptional pausing

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Jason Saba ◽  
Xien Yu Chua ◽  
Tatiana V Mishanina ◽  
Dhananjaya Nayak ◽  
Tricia A Windgassen ◽  
...  
Keyword(s):  
Base Pair ◽  
Rna Polymerases ◽  
Rna Hairpins ◽  
Rna Biogenesis ◽  
Transcriptional Pausing ◽  
Nascent Rna ◽  
Mechanistic Basis ◽  
Fundamental Mechanism

Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise. Although the structural foundations of pauses prolonged by backtracking or nascent RNA hairpins are recognized, the fundamental mechanism of the elemental pause is less well-defined. Here we report a mechanistic dissection that establishes the elemental pause signal (i) is multipartite; (ii) causes a modest conformational shift that puts γ-proteobacterial RNAP in an off-pathway state in which template base loading but not RNA translocation is inhibited; and (iii) allows RNAP to enter pretranslocated and one-base-pair backtracked states easily even though the half-translocated state observed in paused cryo-EM structures rate-limits pause escape. Our findings provide a mechanistic basis for the elemental pause and a framework to understand how pausing is modulated by sequence, cellular conditions, and regulators.

Local and global analysis of plasticity in ferritic-austenitic duplex steels

2001 ◽  
Vol 11 (PR5) ◽  
pp. Pr5-293-Pr5-300 ◽  
Author(s):  
V. V. Silberschmidt ◽  
M. Ortmayr ◽  
C. Messner ◽  
E. A. Werner
Keyword(s):  
Global Analysis ◽  
Duplex Steels

Do remittances differ depending on migration pathway and length of stay?

2016 ◽  
Vol 1 (1) ◽  
pp. 105-118
Author(s):  
Anita Pugliese ◽  
Julie Ray ◽  
Neli Esipova
Keyword(s):  
Length Of Stay ◽  
First Generation ◽  
Second Generation ◽  
Global Analysis ◽  
Large Sample ◽  
Migration Pathway ◽  
First Generation Migrants ◽  
Second Generation Migrants

This paper reports the results from Gallup’s global analysis of the likelihood of first-generation migrants, second-generation migrants and the native-born to send financial help in the form of money or goods to others inside or outside their respective country of residence. The findings in this paper are based on more than 450,000 interviews conducted through Gallup’s World Poll in 157 countries in 2012, 2013 and 2014. The sample includes more than 26,000 first-generation migrants and more than 20,000 second-generation migrants. The large sample enables Gallup to analyze first-generation migrants by the duration of their stay in their adopted country and compare their remittance behaviors with second-generation migrants and the native-born.

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