ELECTROSPINNING OF ST. JOHN'S WORT OIL LOADED MICROCAPSULES BASED PVA NANOFIBERS

In this study, it was achieved that the production of St. John's Wort oil loadad Eudragit RS 100/PVA microcapsules by emulsion/solvent evaporation method and the microcapsules were embedded in PVA nanofibers. Morphological analysis was carried out with SEM images of both microcapsules and nanofibers. The presence of St. John's Wort oil, PVA and Eudragit RS 100 polymers were confirmed in the chemical structure of microcapsules and nanofibers by FT-IR. According to experimental studies, microcapsules were produced to have a smooth surface, a spherical shape and a uniform particle size. The PVA concentration was kept constant at 10% wt and microcapsule concentrations were applied as 1, 3, 5, 7, and 9 wt %. Then, polymer solution properties were measured, such as conductivity, viscosity, and surface tension. It was determined that viscosity and surface tension values increased with microcapsule concentration increase, while conductivity did not change significantly. Nanofiber production was realized via the electrospinning method under the optimum process parameters. According to the SEM images and histogram, nanowebs have a fine fiber diameter, smooth surface, high quality and no bead structure. In addition, the average microcapsule size is 30 μm, average fiber diameter is 430 nm and the fiber diameter uniformity coefficient is 1,014. It is thought that this nanofiber surface containing microcapsules embedded in St. John's Wort has the potential to be used as a wound dressing.

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PARACETAMOL DRUG LOADED MICROCAPSULE BASED NANOFIBER PRODUCTION

TEXTEH Proceedings ◽

10.35530/tt.2021.30 ◽

2021 ◽

Vol 2021 ◽

pp. 200-207

Author(s):

İ.Y. Mol ◽

F.C. Çallıoğlu ◽

H.K. Güler ◽

M. Geysoğlu

Keyword(s):

Surface Tension ◽

Fibre Diameter ◽

Controlled Drug Release ◽

Electrospinning Process ◽

Core Material ◽

Optimum Process ◽

Sem Images ◽

Eudragit Rs ◽

Uniformity Coefficient ◽

Average Fibre Diameter

In this study, it was aimed to production and characterization of paracetamol (PCT) loaded microcapsules and microcapsule added electro spun PVA nanofibers. Eudragit RS 100 and PVA were used as the shell in the microcapsule structure, and PCT was used as the core material. First of all, the PCT loaded Eudragit RS 100/PVA microcapsules were produced by solvent evaporation method under the optimum process parameters. Then, properties such as conductivity, viscosity and surface tension of the microcapsule loaded PVA solution were measured and the effects of microcapsule concentration on the solution properties were determined. According to the solution results, while the viscosity increased with the microcapsule concentration, conductivity and surface tension did not change significantly except for the PVA-10 sample. After the electrospinning process, fibre morphology was determined by SEM and incorporation of microcapsules into the nanofibers was clearly demonstrated. It was calculated from the SEM images that average microcapsule size is 9.81μm, average fibre diameter is 550 nm and fibre diameter uniformity coefficient is 1.025. Finally, the incorporation of PCT loaded microcapsules into the nanofibers was chemically confirmed by FT-IR analysis. It is thought that the results of this study will be useful for controlled drug release, especially in medical textiles.

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TWO-STEP CROSSLINKING OF PVP/GEL NANOFIBERS

TEXTEH Proceedings ◽

10.35530/tt.2021.25 ◽

2021 ◽

Vol 2021 ◽

pp. 164-170

Author(s):

H.K. Güler ◽

F.C. Çallıoğlu

Keyword(s):

Fiber Diameter ◽

Experimental Studies ◽

Water Soluble ◽

Diameter Distribution ◽

Sem Images ◽

Crosslinking Process ◽

Different Temperatures ◽

Ft Ir ◽

Ir Analysis ◽

Gel Polymers

In this study, it was achieved that crosslinking of PVP/GEL nanofibers with two-steps. Crosslinking is a process highly important for water-soluble polymers in terms of application areas and mechanical properties. Firstly, crosslinking of PVP polymers experimental studies were carried out via heat treatment at different temperatures and times. Then, GEL polymers were crosslinked with GTA vapour at different times. Morphological analysis was carried out via SEM images and chemical characteristics were determined via FT-IR analysis. Moreover, after the crosslinking process, SD and WL values were calculated. All results showed that before crosslinking of SEM images, nanofibers were smooth, fine and without beads. The average fiber diameter is 196 nm and the fiber diameter distribution is quite uniform. After crosslinking of SEM images, it is expected that all nanowebs will turn from fibrous surfaces to membranous. Generally, SD and WL values decrease with crosslinking time increase. According to all of the SEM images, SD and WL values, optimum conditions were determined for PVP as 4 hours at 180oC and for GEL as 24 hours. Lastly, the presence of PVP and GEL polymers in the nanofiber structure was verified chemically with FT-IR analysis.

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EMULSION ELECTROSPINNING OF POLYVINYLPYRROLIDONE (PVP)/PARACETAMOL NANOFIBERS

TEXTEH Proceedings ◽

10.35530/tt.2021.28 ◽

2021 ◽

Vol 2021 ◽

pp. 193-199

Author(s):

M. Geysoğlu ◽

H.K. Güler ◽

F.C. Çallıoğlu ◽

İ.Y. Mol

Keyword(s):

Surface Tension ◽

Fibre Diameter ◽

Optimum Process ◽

Atmospheric Conditions ◽

Sem Images ◽

Water Emulsion ◽

Average Fibre Diameter ◽

Average Fibre ◽

Ft Ir ◽

Oil In Water Emulsion

This study aimed to achieve Polyvinylpyrrolidone (PVP) nanofiber production including paracetamol (PCT) by oil-in-water emulsion electrospinning. At first, emulsions were prepared at 14 wt % PVP with various PCT concentrations (0, 0.1, 0.3, 0.5, 0.7, 0.9 wt %). Then, solution properties such as viscosity, conductivity, and surface tension were determined. The production of nanofiber samples was carried out by emulsion electrospinning under the optimum process parameters (voltage, distance between electrodes, feed rate, and atmospheric conditions). Finally, the morphological and structural characterization of the nanofiber surface was carried out with SEM and FT-IR. According to the results of emulsion properties, although the change is not remarkable, it tends to increase the viscosity with an increase in PCT concentration. On the other hand, it was observed that surface tension did not change significantly with PCT concentration increasement and while the conductivity of emulsions decreased slightly. When the fibre structure was investigated, average fibre diameter and fibre diameter uniformity were not affected prominently by PCT concentration. From the SEM images, it is possible to say that generally fine, uniform and bead-free drug-loaded nanofibers were obtained. The finest (326 nm) and most uniform (1.03) nanofibers were achieved from the sample N4 which included 0.5 wt % PCT. Also, the FT-IR results verified that PVP and PCT exist in the nanofiber structure.

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