scholarly journals PARACETAMOL DRUG LOADED MICROCAPSULE BASED NANOFIBER PRODUCTION

2021 ◽  
Vol 2021 ◽  
pp. 200-207
Author(s):  
İ.Y. Mol ◽  
F.C. Çallıoğlu ◽  
H.K. Güler ◽  
M. Geysoğlu
Keyword(s):  
Surface Tension ◽  
Fibre Diameter ◽  
Controlled Drug Release ◽  
Electrospinning Process ◽  
Core Material ◽  
Optimum Process ◽  
Sem Images ◽  
Eudragit Rs ◽  
Uniformity Coefficient ◽  
Average Fibre Diameter

In this study, it was aimed to production and characterization of paracetamol (PCT) loaded microcapsules and microcapsule added electro spun PVA nanofibers. Eudragit RS 100 and PVA were used as the shell in the microcapsule structure, and PCT was used as the core material. First of all, the PCT loaded Eudragit RS 100/PVA microcapsules were produced by solvent evaporation method under the optimum process parameters. Then, properties such as conductivity, viscosity and surface tension of the microcapsule loaded PVA solution were measured and the effects of microcapsule concentration on the solution properties were determined. According to the solution results, while the viscosity increased with the microcapsule concentration, conductivity and surface tension did not change significantly except for the PVA-10 sample. After the electrospinning process, fibre morphology was determined by SEM and incorporation of microcapsules into the nanofibers was clearly demonstrated. It was calculated from the SEM images that average microcapsule size is 9.81μm, average fibre diameter is 550 nm and fibre diameter uniformity coefficient is 1.025. Finally, the incorporation of PCT loaded microcapsules into the nanofibers was chemically confirmed by FT-IR analysis. It is thought that the results of this study will be useful for controlled drug release, especially in medical textiles.

scholarly journals ELECTROSPINNING OF ST. JOHN'S WORT OIL LOADED MICROCAPSULES BASED PVA NANOFIBERS

2021 ◽  
Vol 2021 ◽  
pp. 171-177
Author(s):  
H.K. Güler ◽  
F.C. Çallıoğlu ◽  
İ.Y. Mol ◽  
M. Geysoğlu
Keyword(s):  
Surface Tension ◽  
Smooth Surface ◽  
Fiber Diameter ◽  
Experimental Studies ◽  
Optimum Process ◽  
Sem Images ◽  
Eudragit Rs ◽  
Uniformity Coefficient ◽  
St John’S Wort ◽  
St John's Wort

In this study, it was achieved that the production of St. John's Wort oil loadad Eudragit RS 100/PVA microcapsules by emulsion/solvent evaporation method and the microcapsules were embedded in PVA nanofibers. Morphological analysis was carried out with SEM images of both microcapsules and nanofibers. The presence of St. John's Wort oil, PVA and Eudragit RS 100 polymers were confirmed in the chemical structure of microcapsules and nanofibers by FT-IR. According to experimental studies, microcapsules were produced to have a smooth surface, a spherical shape and a uniform particle size. The PVA concentration was kept constant at 10% wt and microcapsule concentrations were applied as 1, 3, 5, 7, and 9 wt %. Then, polymer solution properties were measured, such as conductivity, viscosity, and surface tension. It was determined that viscosity and surface tension values increased with microcapsule concentration increase, while conductivity did not change significantly. Nanofiber production was realized via the electrospinning method under the optimum process parameters. According to the SEM images and histogram, nanowebs have a fine fiber diameter, smooth surface, high quality and no bead structure. In addition, the average microcapsule size is 30 μm, average fiber diameter is 430 nm and the fiber diameter uniformity coefficient is 1,014. It is thought that this nanofiber surface containing microcapsules embedded in St. John's Wort has the potential to be used as a wound dressing.

scholarly journals EMULSION ELECTROSPINNING OF POLYVINYLPYRROLIDONE (PVP)/PARACETAMOL NANOFIBERS

2021 ◽  
Vol 2021 ◽  
pp. 193-199
Author(s):  
M. Geysoğlu ◽  
H.K. Güler ◽  
F.C. Çallıoğlu ◽  
İ.Y. Mol
Keyword(s):  
Surface Tension ◽  
Fibre Diameter ◽  
Optimum Process ◽  
Atmospheric Conditions ◽  
Sem Images ◽  
Water Emulsion ◽  
Average Fibre Diameter ◽  
Average Fibre ◽  
Ft Ir ◽  
Oil In Water Emulsion

This study aimed to achieve Polyvinylpyrrolidone (PVP) nanofiber production including paracetamol (PCT) by oil-in-water emulsion electrospinning. At first, emulsions were prepared at 14 wt % PVP with various PCT concentrations (0, 0.1, 0.3, 0.5, 0.7, 0.9 wt %). Then, solution properties such as viscosity, conductivity, and surface tension were determined. The production of nanofiber samples was carried out by emulsion electrospinning under the optimum process parameters (voltage, distance between electrodes, feed rate, and atmospheric conditions). Finally, the morphological and structural characterization of the nanofiber surface was carried out with SEM and FT-IR. According to the results of emulsion properties, although the change is not remarkable, it tends to increase the viscosity with an increase in PCT concentration. On the other hand, it was observed that surface tension did not change significantly with PCT concentration increasement and while the conductivity of emulsions decreased slightly. When the fibre structure was investigated, average fibre diameter and fibre diameter uniformity were not affected prominently by PCT concentration. From the SEM images, it is possible to say that generally fine, uniform and bead-free drug-loaded nanofibers were obtained. The finest (326 nm) and most uniform (1.03) nanofibers were achieved from the sample N4 which included 0.5 wt % PCT. Also, the FT-IR results verified that PVP and PCT exist in the nanofiber structure.

scholarly journals ELECTROSPINNING OF ANTIBACTERIAL POLYURETHANE/ZnO NANOFIBERS

2021 ◽  
Vol 2021 ◽  
pp. 185-192
Author(s):  
İ.Y. Mol ◽  
F.C. Çallioğlu
Keyword(s):  
Surface Tension ◽  
Antibacterial Activity ◽  
Water Vapour ◽  
Fibre Diameter ◽  
Water Vapour Permeability ◽  
Solution Viscosity ◽  
Optimum Process ◽  
Solution Properties ◽  
Vapour Permeability ◽  
Zno Nanofibers

In this study, it is aimed to produce and characterize antibacterial polyurethane (PU)/Zinc oxide (ZnO) nanofibers by electrospinning method. Firstly, polymer solutions were prepared at various ZnO concentrations such as 0, 0.2, 0.4, 0.6, 0.8, 1. Then solution properties (conductivity, viscosity, surface tension) were determined and analysed the effects of ZnO concentration on the solution properties. PU/ZnO nanofibers produced via electrospinning under the optimum process parameters (voltage, distance between electrodes, feed rate and atmospheric conditions). Finally, the nanofibers were characterized in terms of fibre morphology, thermal stability, permeability and antibacterial activity using SEM-EDS, DSC-TGA, water vapour permeability and disk diffusion methods. According to the solution results; it was observed that conductivity and surface tension decrease significantly with ZnO addition. On the other hand, solution viscosity increases as the ZnO concentration increases. From the SEM images, it has been seen clearly that average fibre diameter increases with ZnO concentration and incorporation of ZnO particles to the fibre structure was verified by SEM-EDS. According to the thermal analyse result, nanofibers begin to degrade between 271.94 ºC and 298.73 ºC. In addition, water vapour permeability increases as the ZnO concentration increase. Lastly antibacterial activity against gram negative (E.coli) and gram positive (S. aureus) was determined with specific zone diameter.

scholarly journals Comparative analysis of superabsorbent properties of PVP and PAA nanofibres

2021 ◽  
Vol 72 (04) ◽  
pp. 460-466
Author(s):  
BUKET GÜLER ◽  
FUNDA CENGİZ ÇALLIOĞLU
Keyword(s):  
Surface Tension ◽  
Comparative Analysis ◽  
Fibre Diameter ◽  
Volume Ratio ◽  
High Specific Surface Area ◽  
Absorption Capacity ◽  
Solution Viscosity ◽  
Optimum Process ◽  
Absorption Properties ◽  
Synthetic Urine

This study presents the comparative analysis of production, characterization and absorption properties of Polyvinylpyrrolidone (PVP) and Polyacrylic acid (PAA) nanofibres. Firstly, optimization studies about polymer (PVP and PAA), superabsorbent additive (waterlock)(WL) and crosslinker agent (sodium persulfate and glutaraldehyde)concentrations were achieved. Then solution properties such as conductivity, surface tension and viscosity were determined. Electrospinning was carried out under the optimum process parameters (voltage, distance between the electrodes, solution feed rate etc.) to obtain superabsorbent nanofibrous surfaces. Surface and fibre morphologies were analysed with Scanning Electron Microscopy (SEM) and thickness of nanoweb and weight in grams of nanofibres were also measured. Lastly, optimized PVP and PAA nanofibres were compared in terms of absorption properties with water and synthetic urine with various times from 5 to 86400 seconds. According to the results, generally fine, smooth and uniform nanofibres were obtained. It was observed that the solution viscosity, conductivity, and average fibre diameter increase with waterlock (WL) and cross-linker additions while surface tension was not change. In addition, PAA nanofibres’ absorption capacity with water and synthetic urine was higher than PVP nanofibres, while PVP nanofibres’ absorption rate is higher. It is possible to say that electrospun nanofibrous surfaces that are ultra-thin, light, porous and with high specific surface area to volume ratio are promising for new superabsorbent materials.

Dextran nanofiber production by needleless electrospinning process

e-Polymers ◽  
2014 ◽  
Vol 14 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Funda Cengiz-Çallıoğlu
Keyword(s):  
Surfactant Concentration ◽  
Water Solution ◽  
Electrospinning Process ◽  
Optimum Process ◽  
Fiber Density ◽  
Uniformity Coefficient ◽  
High Fiber ◽  
Fiber Properties ◽  
Needleless Electrospinning ◽  
Electrospinning Method

AbstractThis article presents the formation of a dextran nanofibrous layer by needleless electrospinning. Optimum process parameters such as polymer solution and addition (surfactant) concentration, voltage, distance, etc. were determined to obtain uniform and smooth dextran nanofibers. It was not possible to produce nanofibers from pure dextran/water solution. Instead, solution drops were deposited on the collector; therefore, anionic surfactant was added in various concentrations to start the nanofiber production. Also, the effects of surfactant concentration on the solution properties, spinnability and fiber properties were determined. Generally, uniform and fine nanofibers were obtained from the rod electrospinning method. The value of 2 wt% surfactant concentration was chosen as the optimum concentration to produce a dextran nanofibrous layer by roller electrospinning. According to the results, spinning performance was 0.6726 g/min per meter, average fiber diameter was 162 nm, diameter uniformity coefficient was 1.03 and the nonfibrous area was 0.5%. In conclusion, this methodology resulted in the production of good product properties such as good spinnability, fine and uniform nanofibers and high fiber density.

Effect of Molecular Weight on Morphological Structure of Electrospun PVA Nanofibre

2015 ◽  
Vol 1134 ◽  
pp. 203-208
Author(s):  
Nur Athirah Abdullah@Shukry ◽  
Khairunnadim Ahmad Sekak ◽  
Mohd Rozi Ahmad
Keyword(s):  
Molecular Weight ◽  
Polyvinyl Alcohol ◽  
Feed Rate ◽  
Fibre Diameter ◽  
Morphological Structure ◽  
Electrospinning Process ◽  
Molecular Weights ◽  
Microscopy Technique ◽  
Average Fibre Diameter ◽  
Average Fibre

This work focuses on the preparation of electrospun Polyvinyl Alcohol (PVA) nanofibres of three different molecular weights. The electrospinning process parameters were varied in terms of the voltage and feed rate. Scanning Electron Microscopy technique was used to characterize the morphological structure of the electrospun PVA nanofibre. The results show that the average fibre diameter increased as the molecular weight of the polymer increased. The formation of beads occurs from the lowest molecular weight sample of 89K However, long, continuous and beaded-free fibres were obtained from the 125K and 205K polymer weight PVA. The results also suggest that higher spinning voltage and feed rate produce larger fibre diameter, respectively.Keywords : Polyvinyl Alcohol, nanofibres, molecular weight, electrospinningCorresponding Author:Khairunnadim Ahmad Sekak, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Shah Alam, 40450 Selangor Darul Ehsan.Email: [email protected]

scholarly journals SOLVENT OPTIMIZATION OF ELECTROSPUN POLY(ACRYLIC ACID) NANOFIBERS

2021 ◽  
Vol 2021 ◽  
pp. 178-184
Author(s):  
M. Geysoğlu ◽  
F.C. Çallıoğlu
Keyword(s):  
Surface Tension ◽  
Acrylic Acid ◽  
Ph Value ◽  
Fibre Diameter ◽  
Optimum Process ◽  
Distilled Water ◽  
Solution Properties ◽  
Atmospheric Conditions ◽  
Fibre Morphology ◽  
Poly Acrylic Acid

In this study, it was investigated experimentally the influence of various solvents (distilled water and ethanol) on the solution properties, spinning performance, and fibre morphology of the electro spun Poly (acrylic acid) nanofibers. Firstly, polymer solutions were prepared at 5 wt % PAA with various solvent ratios of ethanol and distilled water. Then, solution properties such as viscosity, density, pH, conductivity, and surface tension were determined. The production of nanofiber samples was carried out by electrospinning under the optimum process parameters (voltage, distance between electrodes, feed rate, and atmospheric conditions). Finally, the morphological characterization of the nanofiber surface was carried out with SEM. According to the results, it was observed that conductivity, surface tension and the density of the solution increase as the ethanol ratio decreases. On the other hand, pH value increases as the ethanol ratio increases and, so, the acidic value of the solutions decreases. The viscosity increased until the ethanol/distilled water ratio was 50/50 and then decreased as the ethanol percentage decreased to under 50%. In addition, average fibre diameter decreases with ethanol ratio decreases. It is possible to say that solvent type affects solution properties, fibre morphology and spinning performance significantly. Generally, fine, uniform and bead free nanofibers could be electro spun and the PAA solution containing 70 wt % distilled water and 30 wt % ethanol was selected as the optimum in terms of fibre morphology, web quality and spinning performance.

scholarly journals Experimental Validation of Upward Electrospinning Process

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Faissal Abdel-Hady ◽  
Abdulrahim Alzahrany ◽  
Mostafa Hamed
Keyword(s):  
Gravitational Force ◽  
Vacuum Chamber ◽  
Fibre Diameter ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Needle Size ◽  
Average Fibre Diameter ◽  
Jet Stability ◽  
Average Fibre

An experimental investigation has been carried out to validate the concept of a new upward electrospinning process in producing polymer nanofibres. The role of gravitational force in this concept is reversed from the conventional downward electrospinning. This inversion results in more stretching of the fibre, less bead formation, and jet stability. An experimental setup is built inside a vacuum chamber in order to eliminate the ambient effects. The effect of various parameters such as applied voltage, needle-collector distance, solution concentration, flow rate, and needle size, on average fibre diameter and beads formation, was investigated using scanning electron microscopy (SEM).

scholarly journals Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 635
Author(s):  
Ding Li ◽  
Menglong Wang ◽  
Wen-Liang Song ◽  
Deng-Guang Yu ◽  
Sim Wan Annie Bligh
Keyword(s):  
Controlled Release ◽  
Combined Therapy ◽  
Diffusion Mechanism ◽  
Amorphous State ◽  
Electrospinning Process ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Sem Images ◽  
Release Profiles

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.

scholarly journals Dynamic Response of Thermally Bonded Bicomponent Fibre Nonwovens

2011 ◽  
Vol 70 ◽  
pp. 405-409 ◽  
Author(s):  
Emrah Demirci ◽  
Memiş Acar ◽  
Behnam Pourdeyhimi ◽  
Vadim V. Silberschmidt
Keyword(s):  
Mechanical Properties ◽  
Dynamic Response ◽  
Fibre Diameter ◽  
Orientation Distribution ◽  
Nonwoven Fabric ◽  
Woven Fabrics ◽  
Core Material ◽  
Finite Element Software ◽  
Anisotropic Mechanical Properties ◽  
Fibre Matrix

Having a unique microstructure, nonwoven fabrics possess distinct mechanical properties, dissimilar to those of woven fabrics and composites. This paper aims to introduce a methodology for simulating a dynamic response of core/sheath-type thermally bonded bicomponent fibre nonwovens. The simulated nonwoven fabric is treated as an assembly of two regions with distinct mechanical properties. One region - the fibre matrix – is composed of non-uniformly oriented core/sheath fibres acting as link between bond points. Non-uniform orientation of individual fibres is introduced into the model in terms of the orientation distribution function in order to calculate the structure’s anisotropy. Another region – bond points – is treated in simulations as a deformable bicomponent composite material, composed of the sheath material as its matrix and the core material as reinforcing fibres with random orientations. Time-dependent anisotropic mechanical properties of these regions are assessed based on fibre characteristics and manufacturing parameters such as the planar density, core/sheath ratio, fibre diameter etc. Having distinct anisotropic mechanical properties for two regions, dynamic response of the fabric is modelled in the finite element software with shell elements with thicknesses identical to those of the bond points and fibre matrix.

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