scholarly journals TUCK IN CONJUNCTIVALAUTOGRAFTING WITH IN SITU LIMBAL STEM CELL TRANSPLANTATION IN CASE OF RECURRENT PTERYGIUM IN CENTRAL INDIA

2020 ◽  
pp. 47-48
Author(s):  
Seema Kumari ◽  
M M Jamal
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Recurrence Rate ◽  
Central India ◽  
Limbal Stem Cell Transplantation ◽  
Recurrent Pterygium ◽  
Limbal Stem Cell ◽  
Conjunctival Autografting

AIM: To report outcome and recurrence with Tuck in conjunctival autografting with in situ limbal stem cell transplantation in case of recurrent pterygium in central India where cost is a limiting factor in use of any sutures, Amniotic membrane, Fibrin glue, Mitomycin or Avastin. METHODS: A randomized, non-comparative interventional and prospective clinical study was carried out on 50 patients of recurrent nasal and temporal pterygium at MGM Medical college and Hospital, Jamshedpur from August 2019 to September 2020. Patients with cystic atrophic and Inflamed pterygium, pseudo pterygium, other ocular disorders like Sjogren’s syndrome, blood clotting disorders, glaucoma medication, stents or filtering bleb were excluded from the study. RESULTS: Mean age was32.2 years. Mean follow up was 12.2 months. Outcome measures were cosmetic satisfaction, recurrence rate, graft edema, graft dislocation, graft failure and loss of graft. CONCLUSION: Pterygium being a local limbal stem cell deficiency , its surgical treatment by replenishment of limbal stem cells by tuck in conjunctival autografting with in situ limbal stem cell transplantation is a viable option In cases of recurrent pterygium and is a cheap alternative alleviating need of any sutures, tissue adhesive , antimitotic drugs ,anti VEGFS ,with a lesser intraoperative time, excellent cosmetic result and low recurrence rate.

scholarly journals Limbal stem cell transplantation: current perspectives

2016 ◽  
pp. 593 ◽  
Author(s):  
Guillermo Amescua ◽  
Marwan Atallah ◽  
Sotiria Palioura ◽  
Victor Perez
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Survival of Donor Epithelial Cells after Limbal Stem Cell Transplantation

2005 ◽  
Vol 46 (3) ◽  
pp. 803 ◽  
Author(s):  
Ali R. Djalilian ◽  
Sankaranarayana P. Mahesh ◽  
Christian A. Koch ◽  
Robert B. Nussenblatt ◽  
DeFen Shen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

scholarly journals Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
J. Behaegel ◽  
S. Ní Dhubhghaill ◽  
C. Koppen ◽  
N. Zakaria
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Health Risks ◽  
Ex Vivo ◽  
Good Manufacturing Practice ◽  
Surgical Approaches ◽  
Potential Health ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency. While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little has been reported regarding the potential health risks associated with production processes and transplantation techniques. Culture procedures require the use of animal and/or human-derived products, which carry the potential of introducing toxic or infectious agents through contamination with known or unknown additives. Protocols vary widely, and the risks depend on the local institutional methods. Good manufacturing practice and xeno-free culture protocols could reduce potential health risks but are not yet a common practice worldwide. In this review, we focus on the safety of both autologous- and allogeneic-cultivated limbal stem cell transplantation, with respect to culture processes, surgical approaches, and postoperative strategies.

scholarly journals Recent Advances in the Effects of Various Surgical Methods on Tear Film after Pterygium Surgery

2021 ◽  
Author(s):  
Juan Wang
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Dry Eye ◽  
Tear Film ◽  
Amniotic Membrane Transplantation ◽  
Surgical Methods ◽  
Close Relationship ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Pterygium is a common ocular disorder with a high prevalence. Surgical resection is the main method of treating pterygium. Recurrence rate of traditional surgical methods such as simple excision of pterygium is high. In recent years, amniotic membrane transplantation, autologous limbal stem cell transplantation, application of mitomycin (MMC) and some other methods become commonly used. Autologous limbal stem cell transplantation is being most widely used. Pterygium has a close relationship with dry eye, and dry eye is one of the important reasons for its recurrence. Different surgical methods have different effects on postoperative tear film. This review will summarize the recent points.

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