scholarly journals Recent Advances in the Effects of Various Surgical Methods on Tear Film after Pterygium Surgery

2021 ◽  
Author(s):  
Juan Wang
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Dry Eye ◽  
Tear Film ◽  
Amniotic Membrane Transplantation ◽  
Surgical Methods ◽  
Close Relationship ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Pterygium is a common ocular disorder with a high prevalence. Surgical resection is the main method of treating pterygium. Recurrence rate of traditional surgical methods such as simple excision of pterygium is high. In recent years, amniotic membrane transplantation, autologous limbal stem cell transplantation, application of mitomycin (MMC) and some other methods become commonly used. Autologous limbal stem cell transplantation is being most widely used. Pterygium has a close relationship with dry eye, and dry eye is one of the important reasons for its recurrence. Different surgical methods have different effects on postoperative tear film. This review will summarize the recent points.

scholarly journals Comparison between limbal stem cell versus dry amniotic membrane transplantation in treatment of primary pterygium

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Ghanem ◽  
F M Zaher ◽  
A G Salman ◽  
R M Nabil
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Significant Difference ◽  
Limbal Stem Cell Transplantation ◽  
Pterygium Excision ◽  
Limbal Stem Cell

Abstract Background Pterygium is a degenerative disorder of the conjunctiva which leads to encroachment of bulbar conjunctiva onto the cornea. This invasion causes irritation of ocular surface, irregular astigmatism and loss of visual acuity.surgical treatment of pterygium is directrd towards excision, prevention of recurrence and restoration of ocular surface integrity. A myriad of techniques have been described for achieving these goals. Tha main complication of these procedures is the recurrence rate, which has been estimated as high as 30%_70%. Purpose to compare the efficiency of limbal stem cell transplantation versus dry amniotic membrane transplantation in treatment of pterygium. Patients and Methods The study carried out at ophthalmology department, Ain shams university and included 20 eyes which were classified into two groups; first group included 10 eyes of patients underwent pterygium excision with amniotic membrane transplantation. Second group included 10 eyes of patients underwent pterygium excision with limbal stem cell transplantation. Results the mean follow up duration was 1-3 months in both groups. On comparing recurrence rate between the studied groups which occurred only in the first group in two eyes 20%, there is no statistically significant difference found between the studied groups as regard recurrence. But it was statistically significant better with limbal conjunctival autografting. Graft rejection was not detected in the two groups during follow up period. There was no statistically significant difference found between the studied groups as regard clinical stability and graft rejection. Conclusion Limbal stem cell transplantation proved to be better than amniotic membrane transplantation in treatment of pterygium. As it is more effective in prevention of pterygium reccurence as well as it is of lower cost and better availability than amniotic membrane.

scholarly journals Limbal stem cell transplantation: current perspectives

2016 ◽  
pp. 593 ◽  
Author(s):  
Guillermo Amescua ◽  
Marwan Atallah ◽  
Sotiria Palioura ◽  
Victor Perez
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Survival of Donor Epithelial Cells after Limbal Stem Cell Transplantation

2005 ◽  
Vol 46 (3) ◽  
pp. 803 ◽  
Author(s):  
Ali R. Djalilian ◽  
Sankaranarayana P. Mahesh ◽  
Christian A. Koch ◽  
Robert B. Nussenblatt ◽  
DeFen Shen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

scholarly journals Safety of Cultivated Limbal Epithelial Stem Cell Transplantation for Human Corneal Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
J. Behaegel ◽  
S. Ní Dhubhghaill ◽  
C. Koppen ◽  
N. Zakaria
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Health Risks ◽  
Ex Vivo ◽  
Good Manufacturing Practice ◽  
Surgical Approaches ◽  
Potential Health ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell

Ex vivo cultivated limbal stem cell transplantation is a promising technique for the treatment of limbal stem cell deficiency. While the results of the clinical trials have been extensively reported since the introduction of the technique in 1997, little has been reported regarding the potential health risks associated with production processes and transplantation techniques. Culture procedures require the use of animal and/or human-derived products, which carry the potential of introducing toxic or infectious agents through contamination with known or unknown additives. Protocols vary widely, and the risks depend on the local institutional methods. Good manufacturing practice and xeno-free culture protocols could reduce potential health risks but are not yet a common practice worldwide. In this review, we focus on the safety of both autologous- and allogeneic-cultivated limbal stem cell transplantation, with respect to culture processes, surgical approaches, and postoperative strategies.

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