Role of CEA and CA19-9 in Predicting Metastasis, Operability and Resectability in Patients of Carcinoma Gall Bladder

BACKGROUND Gallbladder cancer is recognised as an irreversible malignancy with a high fatality rate. The highest incidence of gall bladder carcinoma is seen in India and Chile, and relatively low level in many Western countries. Gall bladder carcinoma has an extremely poor prognosis, increasing incidence, and diagnosed at an advanced stage despite recent advances in diagnostic modalities. Considering the high rate of mortality attributable mainly to late detection of disease at an advanced stage, early diagnosis remains to be one of the most important determinants of the outcome. This study was conducted to assess the role of tumour markers, namely carbohydrate antigen (CA 19-9), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in the diagnosis of gall bladder carcinoma. We wanted to assess the diagnostic role of tumour markers in carcinoma gall bladder. METHODS Patients with radiologically and histopathologically confirmed diagnosis of carcinoma gall bladder were invited to participate in the study. A thorough history was taken, and relevant examination done as per protocol. All necessary laboratory and radiologic investigations were done according to study design. Assessment of the tumour markers CA19-9, CEA and AFP was done, and values compared with carcinoma gall bladder patients. RESULTS The diagnostic value of tumour markers has been studied in context with histopathological grade as all the cases were histopathologically proven cases of carcinoma gall bladder (Ca GB). CONCLUSIONS The present study showed that CA 19-9 was most effective with regard to its ability to differentiate between different grades of gall bladder carcinoma. KEY WORDS CA 19-9, CEA, AFP, Carcinoma Gallbladder

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Role of Tumor Markers CA 19-9 (Carbohydrate Antigen), CEA (Carcinoembryogenic Antigen), & AFP (Alpha Feto Protein) in Carcinoma Gall Bladder

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i4.155 ◽

2019 ◽

Vol 7 (4) ◽

Author(s):

Dr Chandra Shekhar MBBS ◽

Keyword(s):

Gall Bladder ◽

Tumor Markers ◽

Carbohydrate Antigen ◽

Carcinoma Gall Bladder ◽

Alpha Feto Protein

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Role of MSCT in the diagnosis of perforated gall bladder (a retrospective study)

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-019-0128-2 ◽

2020 ◽

Vol 51 (1) ◽

Cited By ~ 1

Author(s):

Mohamed M. Harraz ◽

Ahmed H. Abouissa

Keyword(s):

Computed Tomography ◽

Retrospective Study ◽

Gall Bladder ◽

Acute Cholecystitis ◽

Acute Diverticulitis ◽

Wall Thickening ◽

Free Fluid ◽

Iodinated Contrast ◽

Contrast Enhanced

Abstract Background Although gall bladder perforation (GBP) is not common, it is considered a life-threating condition, and the possibility of occurrence in cases of acute cholecystitis must be considered. The aim of this study was to assess the role of multi-slice computed tomography (MSCT) in the assessment of GBP. Results It is a retrospective study including 19 patients that had GBP out of 147, there were 11 females (57.8%) and 8 males (42.1%), aged 42 to 79 year (mean age 60) presented with acute abdomen or acute cholecystitis. All patients were examined with abdominal ultrasonography and contrast-enhanced abdominal MSCT after written informed consent was obtained from the patients. This study was between January and December 2018. Patients with contraindications to contrast-enhanced computed tomography (CT) (pregnancy, acute kidney failure, or allergy to iodinated contrast agents) who underwent US only were excluded. Patients with other diagnoses, such as acute diverticulitis of the right-sided colon or acute appendicitis, were excluded. The radiological findings were evaluated such as GB distention; stones; wall thickening, enhancement, and defect; pericholecystic free fluid or collection; enhancement of liver parenchyma; and air in the wall or lumen. All CT findings are compared with the surgical results. Our results revealed that the most important and diagnostic MSCT finding in GBP is a mural defect. Nineteen patients were proved surgically to have GBP. Conclusion GBP is a rare but very serious condition and should be diagnosed and treated as soon as possible to decrease morbidity and mortality. The most accurate diagnostic tool is the CT, MSCT findings most specific and sensitive for the detection of GBP and its complications.

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