scholarly journals Role of positive peritoneal lavage cytology in carcinoma gall bladder: a prospective observational study of 60 patients with the preoperative diagnosis

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S704-S705
Author(s):  
A. Vijayashanker ◽  
T.D. Yadav ◽  
V. Gupta ◽  
R. Srinivasan ◽  
A. Das ◽  
...  
Keyword(s):  
Observational Study ◽  
Gall Bladder ◽  
Preoperative Diagnosis ◽  
Prospective Observational Study ◽  
Peritoneal Lavage ◽  
Peritoneal Lavage Cytology ◽  
Carcinoma Gall Bladder ◽  
Lavage Cytology

scholarly journals Role of digital photography in evaluation of gallbladder specimens following laparoscopic cholecystectomy for gallstone disease: a prospective observational study

2019 ◽  
Vol 6 (4) ◽  
pp. 1376
Author(s):  
Vidyasagar . ◽  
Manjunath Maruti Pol ◽  
Sunil Chumber ◽  
Yashwant Singh Rathor
Keyword(s):  
Observational Study ◽  
Gall Bladder ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Prospective Observational Study ◽  
Histopathological Examination ◽  
Digital Photography ◽  
Resected Specimen ◽  
Abnormal Finding ◽  
Carcinoma Gall Bladder

Background: Digital photography helps in accurate documentation of macroscopic features of specimens and preventing inaccuracies in description of macroscopic features. Some studies recommend a digital color print be sent with each specimen to histopathology laboratory. The aim of the study was to assess the necessity of histopathological examination of resected specimen of gallbladder with no features suspicious of carcinoma gall bladder on clinicoradiological study.Methods: It is a prospective observational study conducted in the Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, between 2014 and 2016. Patients between 18 to 60 years of age with gall stone disease with no features suspicious of carcinoma gall bladder on clinicoradiological study were recruited in the study. Post-cholecystectomy gallbladder specimens were considered as subjects of study. Specimen were photographed and sent for histopathological examination. Macroscopic features on digital photography were compared with histopathological findings.Results: About, 39/100 (39%) gallbladder specimens showed abnormal findings on digital photography; 30/39 (77%) had ulcerations, 5/39 (13%) had polypoidal lesions and 4/39 (10%) had diffuse wall thickening. 1/39 (2.6%) specimens with abnormal finding on digital photography was found to be malignant on histopathological examination. The sensitivity, specificity, negative predictive value and positive predictive value of digital photography was 100%, 67.7%, 100% and 3.03% respectively.Conclusions: Digital photography can prove to be a good tool in documenting macroscopic features of gallbladder specimens. Digital photography is associated with high sensitivity and negative predictive value; however, larger sample size is required to establish its significant correlation.

Multicenter retrospective observational study of pancreatic cancer with positive peritoneal lavage cytology intended for surgical resection.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 695-695
Author(s):  
Akiko Todaka ◽  
Satoshi Nara ◽  
Fuyuhiko Motoi ◽  
Soichiro Morinaga ◽  
Naoki Hama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Adjuvant Chemotherapy ◽  
Observational Study ◽  
Surgical Resection ◽  
Curative Resection ◽  
Peritoneal Lavage ◽  
Treatment Strategies ◽  
Retrospective Observational Study ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology

695 Background: Although macroscopically curative resection has been performed for pancreatic cancer with positive peritoneal lavage cytology (CY1), the prognosis is poor in most reports. In 2013, the JASPAC01 trial showed that S-1 was superior to Gemcitabine (GEM) as adjuvant chemotherapy for resected pancreatic cancer, and S-1 was also administered to the patients with CY1 who had undergone macroscopically curative resection. Methods: This is a multicenter retrospective observational study that collected data of the patients with pancreatic adenocarcinoma who were diagnosed with CY1 between 2007 and 2015 and had no other noncurable factors. Results: One hundred twenty-seven patients were enrolled from 14 institutions, and 3 were excluded due to liver metastasis or non-adenocarcinoma. The median age was 67 years old and almost patients had PS 0 or 1. Of the 124 patients, 114 underwent macroscopically curative resection and the median overall survival (OS) and recurrence free survival (RFS) were 16.7 and 7.2 months. Of the resected patients, 80 (70%) had no early recurrence and started postoperative adjuvant chemotherapy. Adjuvant chemotherapy regimens were S-1 in 43 patients (54%), GEM in 31 (39%) and others in 6 (7%). The median OS was 21.0 months with S-1 and 19.2 months with GEM (HR: 0.73, 95%CI: 0.44-1.22, P = 0.23), whereas the median RFS was 10.2 and 7.1 months (HR: 0.58, 95%CI: 0.36-0.95, P = 0.03), respectively. Conclusions: After the report of JASPAC01, most patients with pancreatic cancer with CY1 received macroscopically curative resection and treated with S-1 as adjuvant therapy, however the efficacy was insufficient. We should consider appropriate treatment strategies for patients with pancreatic cancer with CY1 intended for surgical resection.

scholarly journals ROLE OF PERITONEAL LAVAGE CYTOLOGY IN SURGERY FOR GASTRIC CANCER

1999 ◽  
Vol 60 (11) ◽  
pp. 2836-2840 ◽  
Author(s):  
Hiroomi TATSUMI ◽  
Hideki URA ◽  
Koji YAMAGUCHI ◽  
Rika FUKUI ◽  
Joji KUROKAWA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Lavage ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology

scholarly journals Serum cystatin is not a marker of glomerular filtration rate in pregnancy

2009 ◽  
Vol 2 (3) ◽  
pp. 121-122 ◽  
Author(s):  
Kate Bramham ◽  
David Makanjuola ◽  
Wael Hussein ◽  
Debra Cafful ◽  
Hassan Shehata
Keyword(s):  
Glomerular Filtration Rate ◽  
Observational Study ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Prospective Observational Study ◽  
Second Trimester ◽  
Third Trimester ◽  
Serum Cystatin ◽  
In Pregnancy

The role of cystatin C (Cys-C) as a marker of glomerular filtration rate (GFR) in pregnancy is undetermined. Measurements of Cys-C and creatinine (Cr) were taken at 14–17+6, 18–23+6, 27–31+6 weeks' gestation, at delivery and 2–6 weeks postpartum in a prospective observational study of 27 women. There was no difference between Cys-C levels in early and late second trimester, but they were significantly higher in early third trimester ( P < 0.001) than second trimester, despite no concurrent increase in Cr. Cys-C was also significantly higher at delivery than at all other times in pregnancy ( P < 0.001) and fell to postpartum values higher than second trimester measurements ( P < 0.01), but lower than delivery ( P<0.001). In conclusion, changes in Cys-C may be influenced by pregnancy-related changes in glomerular filtration and therefore we would advise against their use as a marker of GFR in pregnancy.

scholarly journals The role of rehabilitation measures in reintegration of children with brain tumours or leukaemia and their families after completion of cancer treatment: a study protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e014505 ◽  
Author(s):  
Mona Leandra Peikert ◽  
Laura Inhestern ◽  
Corinna Bergelt
Keyword(s):  
Observational Study ◽  
Cancer Treatment ◽  
Childhood Cancer ◽  
Quantitative Study ◽  
Prospective Observational Study ◽  
Daily Life ◽  
Oncological Rehabilitation ◽  
Rehabilitation Measures

IntroductionFor ill children as well as for their parents and siblings, childhood cancer poses a major challenge. Little is known about the reintegration into daily life of childhood cancer survivors and their families. The aim of this prospective observational study is to further the understanding of the role of rehabilitation measures in the reintegration process of childhood leukaemia or brain tumour survivors and their family members after the end of cancer treatment.Methods and analysisThis prospective observational study consists of three study arms: a quantitative study in cooperation with three German paediatric oncological study registries (study arm 1), a quantitative study in cooperation with a rehabilitation clinic that offers a family-oriented paediatric oncological rehabilitation programme (study arm 2) and a qualitative study at 12-month follow-up including families from the study arms 1 and 2 (study arm 3). In study arm 1, children, parents and siblings are surveyed after treatment (baseline), 4–6 months after baseline measurement and at 12-month follow-up. In study arm 2, data are collected at the beginning and at the end of the rehabilitation measure and at 12-month follow-up. Families are assessed with standardised questionnaires on quality of life, emotional and behavioural symptoms, depression, anxiety, fear of progression, coping and family functioning. Furthermore, self-developed items on rehabilitation aims and reintegration into daily life are used. Where applicable, users and non-users of rehabilitation measures will be compared regarding the outcome parameters. Longitudinal data will be analysed by means of multivariate analysis strategies. Reference values will be used for comparisons if applicable. Qualitative data will be analysed using thematic analysis.Ethics and disseminationThis study has been approved by the medical ethics committee of the Medical Chamber of Hamburg. Data will be published in peer-reviewed journals and presented at conferences.

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