scholarly journals Optiminization of regeneration at the stages of soft tissue augmentation using a collagen matrix

2021 ◽  
Vol 19 (4) ◽  
pp. 317-319
Author(s):  
A. B. Adzhieva ◽  
I. A. Voronov ◽  
S. S. Ivanov ◽  
H. M. Nalchajyan
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Mechanical Stability ◽  
Three Dimensional ◽  
Collagen Matrix ◽  
Soft Tissue Augmentation ◽  
Dimensional Structure ◽  
Soft Tissue Regeneration ◽  
Tissue Augmentation ◽  
Cellular Environment

Lack of adequate width and thickness of periodontal or peri-implant soft tissues can compromise the aesthetics, function or survival of teeth and dental implants. Biomaterials are widely used in dentistry to overcome the disadvantages of autogenous tissue transplantation. The advantage of using biomaterials is that there is no need for re-surgery and that they are available in large quantities. The most widely used biomaterial for soft tissue augmentation is collagen, as it is believed to best mimic the natural cellular environment of the extracellular matrix, although other biomaterials are also candidates for soft tissue regeneration. Collagen matrices differ in composition, three-dimensional structure, elasticity and mechanical stability. Aim. is to review the literature on the optimization of regeneration at the stages of soft tissue augmentation using a collagen matrix.

scholarly journals Tissue Response to a Porous Collagen Matrix Used for Soft Tissue Augmentation

Materials ◽  
2019 ◽  
Vol 12 (22) ◽  
pp. 3721 ◽  
Author(s):  
Jordi Caballé-Serrano ◽  
Sophia Zhang ◽  
Luca Ferrantino ◽  
Massimo Simion ◽  
Vivianne Chappuis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Blood Vessels ◽  
Collagen Matrix ◽  
Giant Cells ◽  
Tissue Response ◽  
Soft Tissue Augmentation ◽  
Proliferating Cells ◽  
Tissue Integration ◽  
Inflammatory Phase ◽  
Tissue Augmentation

A short inflammatory phase and fast ingrowth of blood vessels and mesenchymal cells are essential for tissue integration of a biomaterial. Macrophages play a key role in this process. We investigated invasion of macrophages, blood vessels, and proliferating cells into a highly porous and volume-stable collagen matrix (VCMX) used for soft tissue augmentation around teeth and dental implants. The biomaterial was implanted in submucosal pouches in the canine maxilla, and the tissue response was analyzed at six different time points. Immunohistochemistry was done for proliferating cells (PCNA), macrophages (MAC387), multinucleated giant cells (CD86), and blood vessels (TGM2). Blood rapidly filled the VCMX pores. During the first week, MAC387+ cells populated the VCMX pores, blood vessels and PCNA+ cells invaded the VCMX, and CD86+ scattered cells were observed. At 15 days, MAC387+ cells were scanty, blood vessels had completely invaded the VCMX, the number of proliferating cells peaked, and fibroblasts appeared. At 30 days, MAC387+ were absent, the numbers of proliferating and CD86+ cells had declined, while blood vessel and fibroblast numbers were high. At 90 days, residual VCMX was well-integrated in soft connective tissue. In conclusion, the VCMX elicited a short inflammatory phase followed by rapid tissue integration.

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