scholarly journals Factors Affecting The Outcome of in Vitro Fertilization (IVF)

2022 ◽  
Vol 7 (1) ◽  
pp. 444
Author(s):  
Fayka Putri Poempida ◽  
Jimmy Yanuar ◽  
Hamdani Lunardhi ◽  
Samsulhadi Samsulhadi ◽  
Relly Y. Primariawan
Keyword(s):  
In Vitro Fertilization ◽  
Maternal Smoking ◽  
Maternal Age ◽  
Smoking Habits ◽  
P Value ◽  
Maternal Body Mass Index ◽  
Vitro Fertilization ◽  
Sperm Abnormality ◽  
Maternal Bmi

The high prevalence of infertility motivated researchers to find a solution, henceforth In Vitro Fertilization was invented. Factors that affect the outcome of IVF may include sperm analysis, maternal Body Mass Index (BMI), maternal smoking habits, endometriosis, and maternal age. However, there are ongoing debates about the role of said factors regarding the outcome of IVF. The objective of this research is to analyze those factors. This research is a Case-Control study with an analytical observational design. Data were retrieved from patients’ medical records undergoing IVF in Graha Amerta Fertility Clinic from January 2019-October 2020. First, the Chi-Square Test revealed sperm abnormality (p=0.212), Maternal BMI (p=0.427), endometriosis (p=0.067), meaning there was no connection with the outcome of IVF. Simultaneously, maternal age (p=0.037) showed a connection with the outcome of IVF. From the Binary Logistic Regression Test, maternal age 36-40 years old (p=0.044) affects the outcome of IVF significantly. Concurrently maternal BMI, endometriosis, and sperm abnormality have p value>0.05 meaning it is insignificant to the outcome of IVF. This research concluded that sperm abnormality, maternal BMI, and endometriosis do not affect the outcome of IVF. There was no data about maternal smoking habits. Whilst maternal age affects the outcome of IVF. Conclusion: This research concluded that sperm abnormality, maternal BMI, and endometriosis do not affect the outcome of IVF. There was no data about maternal smoking habits. Whilst maternal age affects the outcome of IVF.

scholarly journals Retrospective study of multiple factors imparting effect on pregnancy outcomes in an in-vitro-fertilization centre

2020 ◽  
Vol 9 (6) ◽  
pp. 2516
Author(s):  
Preksha T. Singh ◽  
Shreyans D. Singhvi ◽  
Utkarsh Kachhia ◽  
Trishala Punjabi ◽  
Shital Punjabi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Statistical Difference ◽  
P Value ◽  
Fresh Embryo Transfer ◽  
Vitro Fertilization ◽  
Multiple Factors

Background: Assisted reproductive technology (ART) cycles include in vitro fertilization of the sperm and ovum and transferring the embryo formed into the uterus of the patients. In ART cycles, there is still a shroud of doubt regarding the pregnancy outcomes of embryo transfer on day 3 versus the embryo transfers on day 5 as well the better pregnancy outcome with fresh versus frozen embryo transfer and the number of embryos transferred. This study is aimed to evaluate these factors and study the way to optimize methods to obtain highest pregnancy outcomes.Methods: A retrospective study was performed of 87 patients who had undergone embryo transfers during the duration of the study from an IVF centre in Ahmedabad. Multiple factors were studied and the clinical outcome was tabulated. The pregnancy outcomes were compared using the values of beta- hcg (human chorionic gonadotropin). The data was compiled and analyzed using Google spreadsheets. To find the statistical difference between different factors- the statistical method of Fischer’s exact test and p-value was used.Results: No statistical difference between day 3 and day 5 embryo transfer as well as between frozen and fresh embryo transfer were both. All of them were found equally efficacious, although 3 and 5 number of embryo transfers were found efficacious.Conclusions: In conclusion authors recommend a day 5 embryo transfer with 3 or 5 embryos which are best-quality frozen or fresh embryos to achieve maximum pregnancy outcomes.

Impact of thawing-loading interval of frozen embryo on pregnancy outcome: retrospective analysis

2021 ◽  
Vol 20 (5) ◽  
pp. 5-11
Author(s):  
A.M. Abbas ◽  
◽  
A.H.A. Hakim ◽  
H.A. Bayoumy ◽  
W.M. Abuelghar ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcome ◽  
Embryo Transfer ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Clinical Pregnancy ◽  
The Other ◽  
P Value ◽  
Vitro Fertilization

Embryo transfer is a critical final step in the in vitro fertilization (IVF) cycle. Much attention has been paid to standardizing the procedures of embryo transfer to improve pregnancy outcome. Objective. To identify the impact of embryo thawing-loading interval (the time interval passing from thawing to loading of frozen embryo into the catheter) on pregnancy outcome. Results. The study was divided into quartiles according to thawing-loading interval in minutes (G I: <60; G II: 60–119; G III: 120–239; G IV: 240 and above). Numerical variables are presented as median and interquartile range, and inter-group differences are compared using the Mann-Whitney U test. Categorical variables are presented as numbers and percentages, and differences are compared using the chi-square test for trend. After adjustment for the age of women, time of previous failed ICSI (Intracytoplasmic sperm injection) trials, number and maturity of transferred embryos, a thawing-loading interval between 60–119 minutes (adjusted odds ratio = 2.222, 95% CI = 1.370 to 3.603, p-value = 0.001) or between 120–239 minutes (adjusted odds ratio = 1.924, 95% CI = 1.172 to 3.161, p-value = 0.010) was independently associated with increased probability of clinical pregnancy compared with a thawing-loading interval of <60 minutes. On the other hand, a thawing-loading interval of ≥240 minutes significantly decreased the probability of clinical pregnancy (adjusted odds ratio = 0.378, 95% CI 0.215 to 0.664, p-value = 0.001). Conclusion. After adjusting for potential confounders, this analysis found that a thawing-loading interval between 60–239 minutes was independently associated with better pregnancy outcomes compared with a thawing-loading interval of <60 minutes. On the other hand, a thawing-loading interval of ≥240 minutes was significantly associated with a worse outcome. Key words: embryo transfer, IVF (in vitro fertilization), frozen embryo, thawing-loading interval

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