Technological innovation can stimulate social economy growth. And regional differences of the innovation capacity directly led to the economic gap. So, the study on regional differences of the contribution the technological innovation to economic growth has important practical significance. China is divided into Developed Region and Developing Region. And technological innovation investment, innovation output and innovation environment are measured by six indexes. The effects of technological innovation on regional economic growth are studied empirically base on panel data model. Study shows that technological innovation indexes are all positive correlated to GDP growth. But there are significant differences of the contribution each index to GDP between Developed Region and Developing Region.