scholarly journals On Optimality of Designs with Three Distinct Eigenvalues

10.37236/2709 ◽  
2013 ◽  
Vol 20 (2) ◽  
Author(s):  
M. R. Faghihi ◽  
E. Ghorbani ◽  
G. B. Khosrovshahi ◽  
S. Tat

Let ${\cal D}_{v,b,k}$ denote the family of all connected block designs with $v$ treatments and $b$ blocks of size $k$. Let $d\in{\cal D}_{v,b,k}$. The replication of a treatment is the number of times it appears in the blocks of $d$. The matrix $C(d)=R(d)-\frac{1}{k}N(d)N(d)^\top$ is called the information matrix of $d$ where $N(d)$ is the incidence matrix of $d$ and $R(d)$ is a diagonal matrix of the replications. Since $d$ is connected, $C(d)$ has $v-1$ nonzero eigenvalues $\mu_1(d),\ldots,\mu_{v-1}(d)$.Let ${\cal D}$ be the class of all binary designs of ${\cal D}_{v,b,k}$. We prove that if there is a design $d^*\in{\cal D}$ such that (i) $C(d^*)$ has three distinct eigenvalues, (ii) $d^*$ minimizes trace of $C(d)^2$ over $d\in{\cal D}$, (iii) $d^*$ maximizes the smallest nonzero eigenvalue and the product of the nonzero eigenvalues of $C(d)$ over $d\in{\cal D}$, then for all $p>0$, $d^*$ minimizes $\left(\sum_{i=1}^{v-1}\mu_i(d)^{-p}\right)^{1/p}$ over $d\in{\cal D}$. In the context of optimal design theory, this means that if there is a design $d^*\in{\cal D}$ such that its information matrix has three distinct eigenvalues satisfying the condition (ii) above and that $d^*$ is E- and D-optimal in ${\cal D}$, then $d^*$ is $\Phi_p$-optimal in ${\cal D}$ for all $p>0$. As an application, we demonstrate the $\Phi_p$-optimality of certain group divisible designs. Our proof is based on the method of KKT conditions in nonlinear programming.

The incidence matrix of a block design is replaced by a normalized version, N, in which the entries are non-negative numbers whose sum is unity. The so-called C-matrix, the information matrix for estimation of treatm ent contrasts, is similarly replaced by the normalized analogue C(N). We study the set of ordered eigenvalues of all C(N) and give a complete specification for three treatments (rows). For any number of treatm ents we characterize the eigenvalues of an im portant subclass of designs for which the non-zero entries in any given block are equal. It is suggested that the natural ordering between designs is upper weak majorization of the eigenvalues. Using this we show how to improve a given N-matrix and this leads to several optimality statements.


2015 ◽  
Vol 52 (1) ◽  
pp. 1-12
Author(s):  
Ryszard Walkowiak

SummaryThis paper considers block designs and row-column designs where the information matrix C has two different nonzero eigenvalues, one of multiplicity 1 and the other of multiplicity h−1, where h is the rank of the matrix C. It was found that for each such design there exists a diagonal positive definite matrix X such that the design is X −1-balanced.


Author(s):  
Muklas Rivai

Optimal design is a design which required in determining the points of variable factors that would be attempted to optimize the relevant information so that fulfilled the desired criteria. The optimal fulfillment criteria based on the information matrix of the selected model.


1982 ◽  
Vol 31 (1-2) ◽  
pp. 53-62
Author(s):  
Sanjeev C. Panandikar

In this paper we discuss some of the properties of the matrix ( NN') of the Generalised Group Divisible (GGD) design with λ ij ; i, j=l,2. The properties are the characteristic roots, the Hasse­Minkowski invariant and the nonexistence theorems. Some new methods for constructing GGD designs are also given.


1975 ◽  
Vol 3 (2) ◽  
pp. 285-288
Author(s):  
H. T. Trivedi ◽  
V. K. Sharma

2012 ◽  
Vol 51 (1) ◽  
pp. 115-130
Author(s):  
Sergei Leonov ◽  
Alexander Aliev

ABSTRACT We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.


Sign in / Sign up

Export Citation Format

Share Document