Zoledronic acid may prevent intra-operative bleeding and recurrence of spinal giant cell tumor

2013 ◽  
Vol 33 (9) ◽  
pp. 990-993
Author(s):  
Wei ZHENG ◽  
Juan WU ◽  
Xiao-yuan HU ◽  
Jian-ru XIAO
Keyword(s):  
Zoledronic Acid ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

scholarly journals Combination of Melatonin and Zoledronic Acid Suppressed the Giant Cell Tumor of Bone in vitro and in vivo

2021 ◽  
Vol 9 ◽  
Author(s):  
Xudong Wang ◽  
Peiqiang Su ◽  
Yan Kang ◽  
Caixia Xu ◽  
Jincheng Qiu ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Osteogenic Differentiation ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Therapeutic Effect ◽  
Antitumor Effect ◽  
Cell Tumor ◽  
Cell Counting ◽  
Migration And Invasion ◽  
Antitumor Effects

Melatonin (Mlt) confers potential antitumor effects in various types of cancer. However, to the best of our knowledge, the role of Mlt in the giant cell tumor of bone (GCTB) remains unknown. Moreover, further research is required to assess whether Mlt can enhance the therapeutic effect of zoledronic acid (Zol), a commonly used anti-GCTB drug. In this research, we investigated the effects of Mlt, Zol, and the combination of these two drugs on GCTB cells’ characteristics, including cell proliferation, apoptosis, osteogenic differentiation, migration, and invasion. The cell counting kit-8 (CCK-8) assay, colony formation assay, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay (TUNEL), alkaline phosphatase (ALP) staining, alizarin red staining (ARS), scratch wound healing assay, and transwell experiment were performed, respectively. Our results showed that Mlt could effectively inhibit the proliferation, migration, and invasion of GCTB cells, as well as promote the apoptosis and osteogenic differentiation of tumor cells. Of note, a stronger antitumor effect was observed when Mlt was combined with Zol treatment. This therapeutic effect might be achieved by inhibiting the activation of both the Hippo and NF-κB pathways. In conclusion, our study suggests that Mlt can be a new treatment for GCTB, which could further enhance the antitumor effect of Zol.

Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone

2013 ◽  
Vol 54 (6) ◽  
pp. 439-449 ◽  
Author(s):  
Carol P. Y. Lau ◽  
Lin Huang ◽  
Kwok Chuen Wong ◽  
Shekhar Madhukar Kumta
Keyword(s):  
Zoledronic Acid ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Cell Tumor

scholarly journals Adjuvant Zoledronic Acid in High‐Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial

2019 ◽  
Vol 24 (7) ◽  
pp. 889 ◽  
Author(s):  
Astrid Lipplaa ◽  
Judith R. Kroep ◽  
Lizz van der Heijden ◽  
Paul C. Jutte ◽  
Pancras C.W. Hogendoorn ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
High Risk ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Cell Tumor ◽  
Randomized Phase Ii

In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid

2017 ◽  
Vol 25 (1) ◽  
pp. 409-419 ◽  
Author(s):  
Isao Shibuya ◽  
Masamichi Takami ◽  
Arei Miyamoto ◽  
Akiko Karakawa ◽  
Akira Dezawa ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
In Vitro Study ◽  
Cell Tumor ◽  
Vitro Study

Local Administration of Zoledronic Acid for Giant Cell Tumor of Bone

Orthopedics ◽  
2015 ◽  
Vol 38 (1) ◽  
pp. e25-e30 ◽  
Author(s):  
Toshihiko Nishisho ◽  
Naoyoshi Hanaoka ◽  
Ryo Miyagi ◽  
Toshinori Sakai ◽  
Shunichi Toki ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Local Administration
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