scholarly journals S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation

2019 ◽  
Vol 70 (1) ◽  
pp. 13-17
Author(s):  
Stefania-Felicia Barbuceanu ◽  
Octavian Tudorel Olaru ◽  
Laura-Ileana Socea ◽  
Constantin Draghici ◽  
Gabriel Saramet ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Daphnia Magna ◽  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Ethyl Bromide ◽  
Phenacyl Bromide ◽  
13C Nmr Spectra ◽  
Ethyl Chloroacetate ◽  
Cytotoxicity Assessment

This paper presents synthesis, characterization and cytotoxicity assessment of six S-alkylated 1,2,4-triazoles derivatives that were obtained by treatment of some 1,2,4-triazole-3-thiones containing in the molecule phenylsulfonylphenyl and propyl or 4-bromophenylsulfonylphenyl and 4-methoxyphenyl fragments with different alkylation agents (ethyl bromide, ethyl chloroacetate or phenacyl bromide) in basic media. The synthesized compounds were physico-chemically characterized and the IR, 1H-NMR, 13C-NMR spectra were consistent with the assigned structures. The cytotoxicity of S-alkylated derivatives was evaluated on Daphnia magna crustacean.

scholarly journals New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity

2009 ◽  
Vol 74 (10) ◽  
pp. 1041-1049 ◽  
Author(s):  
Stefania Barbuceanu ◽  
Gabriela Almajan ◽  
Ioana Saramet ◽  
Constantin Draghici ◽  
Radu Socoteanu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Phenacyl Bromide ◽  
Antibacterial Effects ◽  
Ethyl Chloroacetate ◽  
Diphenyl Sulfone ◽  
New Compounds

Alkylation of the 5-{4-[(4-bromophenyl)sulfonyl]phenyl}-4-(3/4-methylphenyl)- 2,4-dihydro-3H-1,2,4-triazole-3-thiones 3a,b with various alkylation agents, i.e., ethyl bromide, phenacyl bromide and ethyl chloroacetate, afforded the S-substituted 1,2,4-triazoles 4-6a,b. The structures of these new compounds were elucidated by elemental analysis and IR, UV, 1H-NMR, 13C-NMR and MS spectroscopy. The newly synthesized products were tested for their antibacterial effects.

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

Partial least squares modeling of combined infrared, 1H NMR and 13C NMR spectra to predict long residue properties of crude oils

2009 ◽  
Vol 51 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Peter de Peinder ◽  
Tom Visser ◽  
Derek D. Petrauskas ◽  
Fabien Salvatori ◽  
Fouad Soulimani ◽  
...  
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Crude Oils ◽  
13C Nmr Spectra

Synthesis and Characterization of N-butyl-N-methylimidazolium- D-(-)-tartrate Chiral Ionic Liquid

2012 ◽  
Vol 518-523 ◽  
pp. 3989-3992 ◽  
Author(s):  
Yang Zhang ◽  
Xiao Hua Tu ◽  
Cheng Ping Miao ◽  
Jian Yi Wu
Keyword(s):  
Ionic Liquid ◽  
1H Nmr ◽  
Ion Chromatography ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Optical Rotation ◽  
Synthesis And Characterization ◽  
13C Nmr Spectra ◽  
Chiral Ionic Liquid

A novel CIL of N-butyl-N-methyl imidazolium-D-(-)-tartrate has been designed and synthesized by neutralization reaction. Its structure was characterized by 1H-NMR and 13C-NMR spectra, the optical rotation was characterized by polarimeter with the value of-15.0º, and the purity was characterized by ion chromatography with the value of 98.4%.

Analysis of the 1H-NMR and 13C-NMR spectra of poly(5-ethyl-2-vinyl thiophene)

1995 ◽  
Vol 35 (6) ◽  
pp. 719-726 ◽  
Author(s):  
David L. Trumbo
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra

Synthesis, 1H NMR, 13C NMR spectra and conformational preference of open chain ligands on lipophilic macrocycles

Tetrahedron ◽  
1982 ◽  
Vol 38 (3) ◽  
pp. 373-378 ◽  
Author(s):  
V. Bocchi ◽  
D. Foina ◽  
A. Pochini ◽  
R. Ungaro ◽  
G.D. Andreetti
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Conformational Preference ◽  
Open Chain
Sign in / Sign up

Export Citation Format

Share Document