scholarly journals Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

2019 ◽  
Vol 70 (10) ◽  
pp. 3734-3737
Keyword(s):  
Resistance Mechanism ◽  
Chemical Characterization ◽  
Advanced Characterization ◽  
Free Drug ◽  
Drug Resistant ◽  
Infectious Agents ◽  
Physico Chemical ◽  
Severe Infections ◽  
Antibiotic Efficacy

Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR. Keywords: nanoparticles, Colistin, infection, sepsis, pediatrics, epidemiology, neurosurgery, cardiology, pulmonology

scholarly journals Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

2019 ◽  
Vol 70 (10) ◽  
pp. 3734-3737
Author(s):  
Daniela Luminita Ichim ◽  
Letitia Doina Duceac ◽  
Constantin Marcu ◽  
Alin Constantin Iordache ◽  
Irina Mihaela Ciomaga ◽  
...  
Keyword(s):  
Resistance Mechanism ◽  
Chemical Characterization ◽  
Advanced Characterization ◽  
Free Drug ◽  
Drug Resistant ◽  
Infectious Agents ◽  
Physico Chemical ◽  
Severe Infections ◽  
Antibiotic Efficacy

Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR.

Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment

2001 ◽  
Vol 71 (3) ◽  
pp. 342-349
Author(s):  
Lucian Eva ◽  
Letitia Doina Duceac ◽  
Liviu Stafie ◽  
Constantin Marcu ◽  
Geta Mitrea ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Advanced Characterization ◽  
Generation Cephalosporin ◽  
Fourth Generation ◽  
Exchange Method ◽  
Physico Chemical ◽  
Life Threatening ◽  
Double Hydroxide ◽  
Double Hydroxides

The fourth generation cephalosporin antibacterial agent, cefepime, was loaded into layered double hydroxides for enhancing antibiotic efficiency, reducing side effects, as well as achieving the sustained release property. The intercalation of antibiotic into the inter-gallery of ZnAl-layered double hydroxide (LDH) was carried out using ion exchange method, by this constituting a nano-sized organic-inorganic hybrid material for a controlled release novel formulation. Although cefepime is a broad spectrum antibiotic, it has various adverse effects and a significant degradation rate. Thus, the preparation and physico-chemical characterization of nanomaterials able to intercalate this drug is an important study for medical and pharmaceutical field. The antibiotic inclusion into LDHs nanostructure was confirmed by advanced characterization techniques and the release profile of cefepime was analysed with the respect to pH of the simulated media.

Laboratory Methods for the Physico-Chemical Characterization of Recombinant Allergens as Reference Standards

Alergologia ◽  
2020 ◽  
Vol 1 (4) ◽  
pp. 7
Author(s):  
Mariana Vieru ◽  
Florin-Dan Popescu ◽  
Laura Haidar ◽  
Carmen Bunu-Panaitescu
Keyword(s):  
Chemical Characterization ◽  
Reference Standards ◽  
Recombinant Allergens ◽  
Laboratory Methods ◽  
Physico Chemical

Mineralogical and physico-chemical characterization of a sintered feldspathic sand

2010 ◽  
Vol 35 (5) ◽  
pp. 261-267 ◽  
Author(s):  
Wissemn Gallala ◽  
Mohamed Essghaier Gaied ◽  
Borhen Kchaou
Keyword(s):  
Chemical Characterization ◽  
Physico Chemical

Structural and physico-chemical characterization of some soda lime zinc alumino-silicate glasses

2012 ◽  
Vol 358 (23) ◽  
pp. 3280-3288 ◽  
Author(s):  
S. Petrescu ◽  
M. Constantinescu ◽  
E.M. Anghel ◽  
I. Atkinson ◽  
M. Olteanu ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Soda Lime ◽  
Silicate Glasses ◽  
Physico Chemical ◽  
Alumino Silicate

Physico-chemical characterization of city sewage discharged into river Ganga at Varanasi, India

1991 ◽  
Vol 17 (5) ◽  
pp. 469-478 ◽  
Author(s):  
B.D. Tripathi ◽  
M. Sikandar ◽  
Suresh C. Shukla
Keyword(s):  
Chemical Characterization ◽  
Physico Chemical ◽  
River Ganga
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