The Impact of Assisted Reproduction on First Trimester Biochemical Markers in Singleton and Twin Pregnancies

The objective was to determine the effect of in vitro fertilization (IVF) on nuchal translucency, free beta-human chorionic gonadotropin (Free b-HCG) and pregnancy-associated plasma protein-A (Papp-A) measurements for singleton and twin pregnancies. This was a retrospective population-based register study that included 2921women with 11-13 weeks of gestation singleton and twin pregnancies. All patients were evaluated for the first trimester Down syndrome combined screening. We identify the effect of assisted reproductive technologies (ART) such as in vitro fertilization (IVF) on the nuchal translucency (NT), free beta-human chorionic gonadotropin (b-HCG) and pregnancy-associated plasma protein-A (PAPP-A) values. The study included 2921 patients: 2526 with spontaneous conception (86.5%) and 395 following IVF (13.5%); in our study singleton pregnancies were 2660 (91.1%), dichorionic twin pregnancies 232 (7.9%) and 12 (0.4%) monochorionic twin pregnancies. The mean b-HCG were about 56.67 IU/l (95%CI: 54.98-58.36) in singleton pregnancies and 128.08 IU/l (95%CI: 115.72-140.45) in twin pregnancies. PAPP-A mean values in singleton pregnancies were 3.54 IU/l (95%CI: 3.42-3.66) and 5.25 IU/l (95%CI: 4.46-6.08) in twin pregnancies. The results were statistically significant with p value p�01. There were also significant differences between b-HCG values in spontaneous pregnancies HCG 63.35 IU/l (95%CI: 60.14-64.10) and IVF pregnancies HCG 99.9 IU/l (95%CI: 91.8-107.99) with p value p � 0.01. In our study the IVF had no impact on nuchal translucency values. Free b-HCG levels were higher in twin pregnancies and IVF pregnancies. PAPP-A concentrations were exceeded in twin pregnancies.

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First-trimester screening with free β-hCG, PAPP-A, and nuchal translucency in pregnancies conceived by in vitro fertilization

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2004.10.029 ◽

2004 ◽

Vol 191 (6) ◽

pp. S44

Author(s):

Sriram C. Perni ◽

Mladen Predanic ◽

Alexander Friedman ◽

Claudel Jean-Pierre ◽

Robin B. Kalish ◽

...

Keyword(s):

In Vitro Fertilization ◽

First Trimester ◽

Nuchal Translucency ◽

First Trimester Screening ◽

Vitro Fertilization ◽

Trimester Screening ◽

Β Hcg

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CHILDREN AFTER IN VITRO FERTILIZATION

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462399015160 ◽

1999 ◽

Vol 15 (1) ◽

pp. 52-65 ◽

Cited By ~ 30

Author(s):

Simone E. Buitendijk

Keyword(s):

In Vitro Fertilization ◽

Psychomotor Development ◽

Safe Procedure ◽

Vitro Fertilization ◽

Embryo Freezing ◽

High Incidence ◽

Twin Pregnancies ◽

Singleton Pregnancies

This paper provides an overview of the effects of in vitro fertilization (IVF) on the children born from it. One of the main problems with IVF to date remains the high incidence of multiple pregnancies, which carry an inherent higher risk of preterm delivery and, therefore, of increased morbidity and mortality in newborns. Further, singleton pregnancies and twin pregnancies from IVF compared to control singleton or twin pregnancies appear to be at higher risk of preterm birth and low birth weight. Whether this is an effect of the procedure per se or is related to maternal factors, or a combination of both, remains to be studied. The risk of congenital malformations does not, with the available data, seem to be elevated. As of now, it remains unclear whether embryo freezing is a safe procedure. Psychomotor development of children born through IVF does not seem to be disturbed. Until further and more extensive studies are conducted, it remains unclear whether IVF poses long-term risks for the children.

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Pregnancy and perinatal outcomes of first-trimester crown-rump length discordance in dichorionic twin pregnancies after in vitro fertilization

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.152 ◽

2018 ◽

Vol 110 (4) ◽

pp. e49

Author(s):

S. Xiao ◽

M. Mo ◽

H. Zhang ◽

X. Hu ◽

Y. Zeng

Keyword(s):

In Vitro Fertilization ◽

Perinatal Outcomes ◽

First Trimester ◽

Crown Rump Length ◽

Vitro Fertilization ◽

Twin Pregnancies

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Preterm and premature rupture of membranes in pregnancies after in vitro fertilization

Medicinski pregled ◽

10.2298/mpns0508375t ◽

2005 ◽

Vol 58 (7-8) ◽

pp. 375-379 ◽

Cited By ~ 2

Author(s):

Dunja Tabs ◽

Tihomir Vejnovic ◽

Nebojsa Radunovic

Keyword(s):

In Vitro Fertilization ◽

Intrauterine Insemination ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Fertilization Program ◽

Vitro Fertilization ◽

Preterm Premature Rupture ◽

Natural Conception ◽

Singleton Pregnancies

Women conceiving by assisted reproduction are at higher risk for preterm and premature rupture of membranes. The aim of our study was to estimate and compare incidence of preterm premature rupture of membranes in singleton pregnancies of women who conceived by intrauterine insemination and in vitro fertilization, from 1999 to 2003. We investigated 87 women from the intrauterine insemination, and 102 from the in vitro fertilization program. There were no statistically significant differences in regard to preterm and premature rupture of membranes: p>0.75 in two groups. The incidence of premature rupture of membranes was 2.30% (after intrauterine insemination) and 2.94% (after in vitro fertilization). There was no statistically significant differences in regard to preterm and premature rupture of membranes in women who conceived by insemination and in vitro fertilization. Estimated incidence of preterm and premature rupture of membranes was similar to the literature data and also similar to incidence after natural conception.

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