Free Radical Scavenging Effect and Oxidative Stress Protective Activity of Domestic Processed Polygoni Multiflori Radix

2015 ◽  
Vol 44 (6) ◽  
pp. 809-815 ◽  
Author(s):  
Hyun Young Kim ◽  
Jun Young Kim ◽  
Eun Ju Cho ◽  
Ji Myung Choi ◽  
Chung Eun Hwang ◽  
...  
2015 ◽  
Vol 35 ◽  
pp. 6-12 ◽  
Author(s):  
Thiyagarajan Rajeshwari ◽  
Boobalan Raja

This study was planned to assess the antioxidant and free radical scavenging effect of D-carvone against L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride) induced hypertension. Hypertension was encouraged in adult male albino rats of the Wistar strain, considering 180–230 g, by oral administration of the L-NAME (40 mg/kg/ body weight/day) in drinking water for 4 weeks. Rats were cured with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. A significant reduction in the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH), in plasma were perceived in L-NAME induced hypertensive rats. Moreover, in vitro free radical scavenging activity of ABTS+ and DPPH• radical scavenging possible of D-carvone was also quantified. Treatment with D-carvone (5, 10 and 20 mg/kg bw) carries back all the above parameters to near usual level, in which 20 mg/kg displayed the highest effect than that of other two doses. Further, D-carvone displays concentration dependent antioxidant potential. These results suggest that D-carvone acts as an antioxidant and free radical scavenging agent against L-NAME induced hypertension.


2011 ◽  
Vol 6 (3) ◽  
pp. 218-222 ◽  
Author(s):  
P. Thirunavuk ◽  
T. Ramanathan ◽  
R. Shanmugapr ◽  
G. Umamaheswa ◽  
G. Renugadevi

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