Relation between visual acuity, macular retinal thickness, visual field and multifocal electroretinography in patients with retinitis pigmentosa

Abstract Retinitis pigmentosa is an inherited neurodegenerative disease of the retina. We investigated smoking as a modifiable environmental factor for the progression of this currently untreatable disease. Clinical data, smoking history, macular function and morphology including visual acuity, visual field sensitivity, ellipsoid zone width and central retinal thickness were investigated. Association between pack × years and these parameters were evaluated using generalized estimating equation models to adjust confounding factors such as age and sex. A total of 410 patients with retinitis pigmentosa (≥20 years old; 209 female) were included, 164 had a smoking history. Patients without smoking history revealed a better visual acuity than smokers (0.39 versus 0.57, P = 0.001). The pack × years index was associated with worse visual acuity and thinner central retinal thickness after adjusting for age and sex (P = 0.0047 and 0.0099, respectively). Visual field and ellipsoid zone width showed a non-significant decline with increasing pack × years. This study indicates an association of smoking with worse macular function and structural integrity in retinitis pigmentosa patients, and hence a potential detrimental effect of smoking on the disease course.

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Chromatic Pupilloperimetry Measures Correlate With Visual Acuity and Visual Field Defects in Retinitis Pigmentosa Patients

Translational Vision Science & Technology ◽

10.1167/tvst.9.8.10 ◽

2020 ◽

Vol 9 (8) ◽

pp. 10

Author(s):

Ifat Sher ◽

Yisroel Tucker ◽

Maya Gurevich ◽

Amit Hamburg ◽

Ettel Bubis ◽

...

Keyword(s):

Visual Acuity ◽

Visual Field ◽

Retinitis Pigmentosa ◽

Visual Field Defects ◽

Field Defects

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Visual Acuity Is Related to Parafoveal Retinal Thickness in Patients with Retinitis Pigmentosa and Macular Cysts

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.08-1992 ◽

2008 ◽

Vol 49 (10) ◽

pp. 4568 ◽

Cited By ~ 28

Author(s):

Michael A. Sandberg ◽

Robert J. Brockhurst ◽

Alexander R. Gaudio ◽

Eliot L. Berson

Keyword(s):

Visual Acuity ◽

Retinitis Pigmentosa ◽

Retinal Thickness

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Regional Relationship between Macular Retinal Thickness and Corresponding Central Visual Field Sensitivity in Glaucoma Patients

Journal of Ophthalmology ◽

10.1155/2017/3720157 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Chun-Hsiu Liu ◽

Shirley H. L. Chang ◽

Shiu-Chen Wu

Keyword(s):

Visual Field ◽

Retinal Thickness ◽

Open Angle Glaucoma ◽

Characteristic Curve ◽

Correlation Coefficients ◽

Warning Sign ◽

Central Visual Field ◽

Field Sensitivity ◽

Macular Retinal Thickness ◽

Sd Oct

Purpose. To investigate the relationship between macular retinal thickness (MRT) and central visual field sensitivity (VFS) in patients with glaucoma.Methods. This retrospective study enrolled patients diagnosed with open-angle glaucoma. All study patients underwent Humphrey 10-2 visual field (VF) test and Spectralis spectral-domain optical coherence tomography (SD-OCT) exam for MRT measurement.Results. Sixty-eight eyes of 68 patients were examined. The correlation coefficients between VFS and MRT were 0.331 (P=0.006) and 0.491 (P=0.000) in the superior and inferior hemispheres, respectively. The average MRT in the eyes with abnormal 10-2 VF hemifields was significantly thinner than that in the eyes without abnormal hemifields in both hemispheres (P=0.005and 0.000 in the superior and inferior hemisphere, resp.). The average MRT values with an optimal sensitivity-specificity balance for discriminating the abnormal VF hemifield from the normal hemifield were 273.5 μm and 255.5 μm in the superior and inferior hemisphere, respectively. The area under the receiver operating characteristic curve was 0.701 in the superior hemisphere and 0.784 in the inferior hemisphere (bothP<0.05).Conclusions. MRT measured through SD-OCT was significantly correlated with central VFS. Lower MRT values might be a warning sign for central VF defects in glaucoma patients.

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A case report of visual outcome in keratoconus with retinitis pigmentosa

10.21203/rs.1.6/v1 ◽

2018 ◽

Author(s):

Chiun-Ho Hou ◽

Yun-Wen Chen ◽

Ken-Kuo Lin ◽

Jiahn-Shing Lee ◽

Lai-Chu See ◽

...

Keyword(s):

Visual Acuity ◽

Visual Field ◽

Retinitis Pigmentosa ◽

Contact Lens ◽

Contact Lenses ◽

Life Quality ◽

Visual Outcome ◽

Visual Aids ◽

Blurred Vision ◽

Visual Rehabilitation

Abstract Background: It is uncommon to see retinitis pigmentosa in keratoconus patients. The main difficulty of visual rehabilitation for this is restricted visual field. We presented the treatment and gene screen of visual system homeobox 1 (VSX 1) gene in this case. Case presentation: A 24-year-old man with retinitis pigmentosa presented with progressively blurred vision. Slit lamp examination revealed Vogt’s striae over both eyes, and corneal topography indicated bilateral keratoconus. We had tested 5 exons of VSX 1 gene from him and the did not find mutation on direct sequence. To improve visual acuity, we prescribed keratoconus rigid gas permeable (RGP) contact lens for him with good efficacy. However, lens dislocation occurred occasionally. He could not find dislocated lens easily due to visual field restriction, so he asked for more stable visual aids. Therefore, we instead prescribed scleral lens (SL), which were more stable on the ocular surface and led to more stable vision. Visual acuity was also gained with SL, but the tolerance time for SL was shorter compared to that of keratoconus RGP contact lens. To compare the efficacy of these two lenses, we surveyed life quality using the National Eye Institute Visual Functioning Questionnaire – 25 in three situations: baseline, with keratoconus RGP contact lens, and with SL. Conclusion: The patient used the two lens types according to his needs, and benefited from vision rehabilitation with both keratoconus RGP contact lens and SL. Keywords: keratoconus; retinitis pigmentosa; rigid gas permeable contact lenses; scleral lenses.

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Correlation between aqueous flare and residual visual field area in retinitis pigmentosa

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312225 ◽

2018 ◽

Vol 103 (4) ◽

pp. 475-480 ◽

Cited By ~ 5

Author(s):

Koji M Nishiguchi ◽

Yu Yokoyama ◽

Hiroshi Kunikata ◽

Toshiaki Abe ◽

Toru Nakazawa

Keyword(s):

Visual Acuity ◽

Visual Field ◽

Retinitis Pigmentosa ◽

Mixed Effects ◽

Macular Thickness ◽

Macular Dystrophy ◽

Linear Mixed Effects Model ◽

Linear Mixed Effects ◽

Aqueous Flare ◽

Field Area

Background/aimsTo investigate the relationship between aqueous flare, visual function and macular structures in retinitis pigmentosa (RP).MethodsClinical data from 123 patients with RP (227 eyes), 35 patients with macular dystrophy (68 eyes) and 148 controls (148 eyes) were analysed. The differences in aqueous flare between clinical entities and the correlation between aqueous flare (measured with a laser flare cell meter) versus visual acuity, visual field area (Goldmann perimetry) and macular thickness (optical coherence tomography) in patients with RP were determined. Influence of selected clinical data on flare was assessed using linear mixed-effects model.ResultsAqueous flare was higher in patients with RP than patients with macular dystrophy or controls (p=7.49×E−13). Aqueous flare was correlated with visual field area (R=−0.379, p=3.72×E−9), but not with visual acuity (R=0.083, p=0.215). Macular thickness (R=0.234, p=3.74×E−4), but not foveal thickness (R=0.122, p=0.067), was positively correlated with flare. Flare was not affected by the presence of macular complications. All these associations were maintained when the right and the left eyes were assessed separately. Analysis by linear mixed-effects model revealed that age (p=8.58×E-5), visual field area (p=8.01×E-7) and average macular thickness (p=0.037) were correlated with flare.ConclusionAqueous flare and visual field area were correlated in patients with RP. Aqueous flare may reflect the degree of overall retinal degeneration more closely than the local foveal impairment.

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Bromfenac 0.09% BID after Nd:YAG laser posterior capsulotomy: evaluation of visual acuity and macular retinal thickness.

Acta Ophthalmologica ◽

10.1111/j.1755-3768.2014.s087.x ◽

2014 ◽

Vol 92 ◽

pp. 0-0

Author(s):

S LOMBARDO ◽

C TINELLI ◽

ER ANTONIAZZI

Keyword(s):

Visual Acuity ◽

Nd:Yag Laser ◽

Retinal Thickness ◽

Posterior Capsulotomy ◽

Macular Retinal Thickness

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The association between multifocal electroretinograms and OCT retinal thickness in retinitis pigmentosa patients with good visual acuity

Eye ◽

10.1038/eye.2008.318 ◽

2008 ◽

Vol 23 (7) ◽

pp. 1524-1531 ◽

Cited By ~ 13

Author(s):

C J Wolsley ◽

G Silvestri ◽

J O'Neill ◽

K J Saunders ◽

R S Anderson

Keyword(s):

Visual Acuity ◽

Retinitis Pigmentosa ◽

Retinal Thickness ◽

Good Visual Acuity ◽

Multifocal Electroretinograms

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Simultaneous changes in visual acuity, cortical population receptive field size, visual field map size, and retinal thickness in healthy human aging

Brain Structure and Function ◽

10.1007/s00429-021-02338-0 ◽

2021 ◽

Author(s):

Maria Fatima Silva ◽

Ben M. Harvey ◽

Lília Jorge ◽

Nádia Canário ◽

Fátima Machado ◽

...

Keyword(s):

Visual Acuity ◽

Visual Field ◽

Receptive Field ◽

Retinal Thickness ◽

Field Size ◽

Human Aging ◽

Healthy Human ◽

Field Representation ◽

Surface Areas ◽

Retinal Structure

AbstractHealthy human aging is associated with a deterioration of visual acuity, retinal thinning, visual field map shrinkage and increasing population receptive field sizes. Here we ask how these changes are related to each other in a cross-sectional sample of fifty healthy adults aged 20–80 years. We hypothesized that age-related loss of macular retinal ganglion cells may lead to decreased visual field map sizes, and both may lead to increased pRF sizes in the cortical central visual field representation. We measured our participants’ perceptual corrected visual acuity using standard ophthalmological letter charts. We then measured their early visual field map (V1, V2 and V3) functional population receptive field (pRF) sizes and structural surface areas using fMRI, and their retinal structure using high-definition optical coherence tomography. With increasing age visual acuity decreased, pRF sizes increased, visual field maps surface areas (but not whole-brain surface areas) decreased, and retinal thickness decreased. Among these measures, only functional pRF sizes predicted perceptual visual acuity, and Bayesian statistics support a null relationship between visual acuity and cortical or retinal structure. However, pRF sizes were in turn predicted by cortical structure only (visual field map surface areas), which were only predicted by retinal structure (thickness). These results suggest that simultaneous disruptions of neural structure and function throughout the early visual system may underlie the deterioration of perceptual visual acuity in healthy aging.

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