A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

10.3791/61609 ◽  
2020 ◽  
Author(s):  
Brittany G. Seman ◽  
Jessica M. Povroznik ◽  
Jordan K. Vance ◽  
Travis W. Rawson ◽  
Cory M. Robinson
Keyword(s):  
Bacterial Sepsis ◽  
Gram Negative ◽  
Imaging Model ◽  
Neonatal Imaging

Diagnostic and prognostic roles of soluble CD22 in patients with Gram-negative bacterial sepsis

2015 ◽  
Vol 14 (5) ◽  
pp. 523-529 ◽  
Author(s):  
Yi-Nan Jiang ◽  
Xun Cai ◽  
Hong-Min Zhou ◽  
Wei-Dong Jin ◽  
Min Zhang ◽  
...  
Keyword(s):  
Bacterial Sepsis ◽  
Gram Negative

scholarly journals Difference of Procalcitonin Levels in Gram-Positive and Gram-Negative Bacterial Sepsis Patients of Indonesia Army Central Hospital Gatot Soebroto in 2016

2022 ◽  
Vol 13 (1) ◽  
pp. 38
Author(s):  
Nindy Handayani ◽  
Soroy Lardo ◽  
Nunuk Nugrohowati
Keyword(s):  
Mean Difference ◽  
P Value ◽  
Central Hospital ◽  
Bacterial Sepsis ◽  
Gram Positive ◽  
Cross Sectional ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Significant Difference ◽  
The Mean

Introduction: Procalcitonin is known as a marker of infection and indicator for severity of infections. In sepsis, elevated procalcitonin levels in blood have a significant value that can be used as a sepsis biomarker. The aim of this study was to determine the mean difference of procalcitonin levels in Gram-positive and Gram-negative bacterial sepsis patients.Methods: This study used quantitative method with cross sectional approach. The sample of this study were bacterial sepsis patients of Indonesia Army Central Hospital Gatot Soebroto in 2016 which were divided into two groups: Gram-positive and Gram-negative bacterial sepsis patients with the number of each group was 30 samples. The data were analyzed by using independent t test.Results: This study showed that mean levels of procalcitonin in Gram-positive bacterial sepsis patients was 6.47 ng/ml and Gram-negative was 66.04 ng/ml. There was a significant difference between mean levels of procalcitonin in Gram-positive and Gram-negative bacterial sepsis patients of Indonesia Army Central Hospital Gatot Soebroto in 2016 with p value = 0.000 (p < 0.05).Conclusion: The mean difference of procalcitonin levels in Gram-negative bacterial sepsis patients were higher than Gram-positive bacterial sepsis patients, because Gram-negative bacteria have lipopolysaccharide which is a strong immunostimulator and increases TNF-α production higher than Gram-positive bacteria. 

scholarly journals Lipopolysaccharide-Trap-Fc, a Multifunctional Agent To Battle Gram-Negative Bacteria

2009 ◽  
Vol 77 (7) ◽  
pp. 2925-2931 ◽  
Author(s):  
Philipp Groß ◽  
Katharina Brandl ◽  
Christine Dierkes ◽  
Jürgen Schölmerich ◽  
Bernd Salzberger ◽  
...  
Keyword(s):  
Myeloid Differentiation ◽  
Gram Negative Bacteria ◽  
Bacterial Sepsis ◽  
Tlr Signaling ◽  
Monocytic Cells ◽  
Gram Negative ◽  
The Family ◽  
Myeloid Differentiation Factor ◽  
Lps Treatment

ABSTRACT The family of Toll-like receptors (TLRs) plays a pivotal role in host defense against pathogens. However, overstimulation of these receptors may lead to uncontrolled general inflammation and eventually to systemic organ dysfunction or failure. With the intent to control overwhelming inflammation during gram-negative bacterial sepsis, we constructed soluble fusion proteins of the lipopolysaccharide (LPS)-receptor complex to modulate TLR signaling in multiple ways. The extracellular domain of mouse TLR4 and mouse myeloid differentiation factor 2 (MD-2) fusions (LPS-Trap) were linked to human immunoglobulin G Fc domains (LPS-Trap-Fc). In addition to the ability to bind LPS or gram-negative bacteria and to inhibit interleukin-6 secretion of monocytic cells after LPS treatment, LPS-Trap-Fc was able to opsonize fluorescent Escherichia coli particles. This led to enhancement of phagocytosis by monocytic cells which was strictly dependent on the presence of the Fc region. Moreover, only LPS-Trap-Fc- and not LPS-Trap-coated bacteria were sensitized to complement killing. Therefore, LPS-Trap-Fc not only neutralizes LPS but also, after binding to bacteria, enhances phagocytosis and complement-mediated killing and could thus act as a multifunctional agent to fight gram-negative bacteria in vivo.

Affinity-Purified Escherichia Coli J5 Lipopolysaccharide-Specific Igg Protects Neutropenic Rats Against Gram-Negative Bacterial Sepsis

1994 ◽  
Vol 170 (3) ◽  
pp. 622-629 ◽  
Author(s):  
A. K. Bhattacharjee ◽  
S. M. Opal ◽  
J. E. Palardy ◽  
J. J. Drabick ◽  
H. Collins ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Bacterial Sepsis ◽  
Gram Negative ◽  
Specific Igg

Confirmatory platelet-activating factor receptor antagonist trial in patients with severe Gram-negative bacterial sepsis

1998 ◽  
Vol 26 (12) ◽  
pp. 1963-1971 ◽  
Author(s):  
Jean-Francois A. Dhainaut ◽  
Alain Tenaillon ◽  
Margaret Hemmer ◽  
Pierre Damas ◽  
Yves Le Tulzo ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Platelet Activating Factor ◽  
Bacterial Sepsis ◽  
Gram Negative ◽  
Platelet Activating Factor Receptor

scholarly journals Carbapenem-induced endotoxin release in Gram-negative bacterial sepsis rat models

1998 ◽  
Vol 21 (4) ◽  
pp. 297-302 ◽  
Author(s):  
Toshinobu Horii ◽  
Miya Kobayashi ◽  
Masayuki Nadai ◽  
Satoshi Ichiyama ◽  
Michio Ohta
Keyword(s):  
Bacterial Sepsis ◽  
Gram Negative ◽  
Rat Models

Immunotherapy of Gram-negative Bacterial Sepsis

1986 ◽  
Vol 121 (1) ◽  
pp. 58 ◽  
Author(s):  
David L. Dunn
Keyword(s):  
Bacterial Sepsis ◽  
Gram Negative

scholarly journals Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis.

1992 ◽  
Vol 36 (9) ◽  
pp. 1971-1977 ◽  
Author(s):  
L W Torley ◽  
W C Pickett ◽  
M L Carroll ◽  
C A Kohler ◽  
R E Schaub ◽  
...  
Keyword(s):  
Animal Models ◽  
Platelet Activating Factor ◽  
Bacterial Sepsis ◽  
Gram Negative ◽  
Factor Antagonist
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