The relationship between 68Ga-PSMA uptake and Gleason Score and PSA levels in patients with prostate cancer

Şadiye ALTUNTUZCU; Bekir TAŞDEMİR; İhsan KAPLAN; Ali UYAR; Fatih GÜZEL; Yunus GÜZEL; Mansur DAĞGÜLLİ

doi:10.38053/acmj.990403

The Utilization of Gleason Grade as the Primary Criterion for Ordering Nuclear Bone Scan in Newly Diagnosed Prostate Cancer Patients

The Scientific World JOURNAL ◽

10.1100/tsw.2009.113 ◽

2009 ◽

Vol 9 ◽

pp. 1040-1045 ◽

Cited By ~ 9

Author(s):

Chad W. M. Ritenour ◽

John T. Abbott ◽

Michael Goodman ◽

Naomi Alazraki ◽

Fray F. Marshall ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Patients ◽

Gleason Score ◽

Bone Scan ◽

Stage Migration ◽

Gleason Grade ◽

Newly Diagnosed ◽

High Gleason Score ◽

Bone Scans ◽

The Relationship

Utilization of nuclear bone scans for staging newly diagnosed prostate cancer has decreased dramatically due to PSA-driven stage migration. The current criteria for performing bone scans are based on limited historical data. This study evaluates serum PSA and Gleason grade in predicting positive scans in a contemporary large series of newly diagnosed prostate cancer patients. Eight hundred consecutive cases of newly diagnosed prostate cancer over a 64-month period underwent a staging nuclear scan. All subjects had histologically confirmed cancer. The relationship between PSA, Gleason grade, and bone scan was examined by calculating series of crude, stratified, and adjusted odds ratios with corresponding 95% confidence intervals. Four percent (32/800) of all bone scans were positive. This proportion was significantly lower in patients with Gleason score ≤7 (1.9%) vs. Gleason score ≥8 (18.8%,p< 0.001). Among patients with Gleason score ≤7, the rate of positive bones scans was 70-fold higher when the PSA was >30 ng/ml compared to ≤30 ng/ml (p< 0.001). For Gleason score ≥8, the rate was significantly higher (27.9 vs. 0%) when PSA was >10 ng/ml compared to ≤10 ng/ml (p= 0.002). The combination of Gleason score and PSA enhances predictability of bone scans in newly diagnosed prostate cancer patients. The PSA threshold for ordering bone scans should be adjusted according to Gleason score. For patients with Gleason scores ≤7, we recommend a bone scan if the PSA is >30 ng/ml. However, for patients with a high Gleason score (8–10), we recommend a bone scan if the PSA is >10 ng/ml.

Download Full-text

Non-alcoholic fatty liver disease increases the risk of biochemical recurrence in high-grade metastatic prostate cancer patients

10.21203/rs.3.rs-141125/v1 ◽

2021 ◽

Author(s):

Jie Cui ◽

Wei zhang ◽

Zhenlong Wang ◽

Yanxiang Chang ◽

Hongyi Zhang

Keyword(s):

Prostate Cancer ◽

Liver Disease ◽

Gleason Score ◽

Biochemical Recurrence ◽

Fatty Liver Disease ◽

Metastatic Prostate Cancer ◽

High Grade ◽

Alcoholic Fatty Liver ◽

The Relationship ◽

Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) has been reported to be helpful to identify high-risk individuals of developing prostate cancer. In the retrospective cohort study, our aim is to investigate the relationship between NAFLD and biochemical recurrence in metastatic prostate cancer patients. Methods We retrospectively investigated 602 patients with metastatic prostate cancer receiving androgen deprivation therapy. Liver fat was estimated with liver-to-spleen ratio by CT scans. The relationship between NAFLD and biochemical recurrence was investigated with Cox models. The model for biochemical recurrence was adjusted for multiple variables. Results NAFLD was significantly associated with biochemical recurrence in patients with Gleason score ≥ 4 + 3 when adjusting for each of body mass index (hazards ratio [HR] = 1.38; 95% confidence interval [CI] = 1.08–1.77; p = 0.01), visceral adipose tissue (HR = 1.36; 95% CI = 1.07–1.74; p = 0.01), hypertension (HR = 1.41; 95% CI = 1.10–1.80; p = 0.01) and diabetes mellitus (HR = 1.42; 95% CI = 1.11–1.82; p = 0.01), using age and prostate-specific antigen level as potential confounder. The 2-year biochemical recurrence rate in Gleason score ≥ 4 + 3 patients with and without NAFLD was 84.0% (100/119) and 72.2% (130/180), respectively (p = 0.018). The median biochemical recurrence free survival of Gleason score ≥ 4 + 3 patients with and without NAFLD were 17 and 21 months, respectively (p = 0.005). Conclusions NAFLD is an independent risk factor for biochemical recurrence in patients with high-grade metastatic prostate cancer. If validated in prospective studies, future research should test whether treatment of NAFLD can lead to better prognosis.

Download Full-text

The relationship between adiposity and gleason score in men with localized prostate cancer

The Prostate ◽

10.1002/pros.21203 ◽

2010 ◽

Vol 70 (15) ◽

pp. 1683-1691 ◽

Cited By ~ 3

Author(s):

Erica E. Hack ◽

D. Robert Siemens ◽

Patti A. Groome

Keyword(s):

Prostate Cancer ◽

Gleason Score ◽

Localized Prostate Cancer ◽

The Relationship

Download Full-text

The Evaluation of PSA levels in Libyan Prostate Cancer Patients

Clinical Oncology Research and Reports ◽

10.31579/2693-4787/029 ◽

2022 ◽

Vol 3 (1) ◽

pp. 01-05

Author(s):

Omar Alqawi ◽

Eman Elshahmi ◽

Fatma Emaetig ◽

Fauzia Elgaraboli ◽

Abubaker Abushnaf

Keyword(s):

Prostate Cancer ◽

Cancer Patients ◽

Gleason Score ◽

Specific Antigen ◽

Developed Countries ◽

P Value ◽

Prostate Cancer Mortality ◽

Psa Testing ◽

The Developed Countries ◽

The Relationship

Background: Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death in men with higher prevalence in the developed countries. The use of biomarkers for prostate cancer can improve the diagnosis of prostate cancer and clinical management of the patients. Prostate-specific antigen (PSA) is widely used to screen for prostate cancer and there is evidence that PSA testing reduces prostate cancer mortality. Objective: In this report we have studied the relationship between the Gleason score, age and PSA levels of prostate adenocarcinoma tissues from Libyan patients to evaluate the levels of PSA in prostate cancer patients. Materials and methods: The data was collected from medical files of 40 patients who underwent curative surgical prostatectomy or prostate true cut biopsy at National Cancer Institute (NCI)-Misurata, Libya during 2016 to 2018. The clinical and histopathological information included age, PSA levels, and Gleason score grade. Results: Our data showed that PSA level was statistically significant correlation with Gleason score grade (p- value = 0.007, <0.05). The increased serum PSA level was associated with the progression of prostate cancer. However, we found no statistically significant correlation between PSA and the age of patients (p- value = 0.435). Conclusion: Our data confirmed the association of high levels of PSA and the progress of prostate cancer.

Download Full-text

S170 The analysis of the relationship between Gleason Score and Positive Core Account of the biopsy in patients with the diagnosis of prostate cancer

European Urology Supplements ◽

10.1016/s1569-9056(13)62203-4 ◽

2013 ◽

Vol 12 (4) ◽

pp. e1278, S170

Author(s):

M.B. Yuksel ◽

A. Karakose ◽

S.N. Gorgel ◽

N. Pirincci ◽

Y.Z. Atesci ◽

...

Keyword(s):

Prostate Cancer ◽

Gleason Score ◽

Positive Core ◽

The Relationship

Download Full-text

The relationship between prostate-specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate-specific antigen levels

The Prostate ◽

10.1002/pros.22985 ◽

2015 ◽

Vol 75 (10) ◽

pp. 1034-1042 ◽

Cited By ~ 18

Author(s):

Kouji Izumi ◽

Hiroko Ikeda ◽

Aerken Maolake ◽

Kazuaki Machioka ◽

Takahiro Nohara ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Patients ◽

Prostate Specific Antigen ◽

Gleason Score ◽

Tnm Classification ◽

Specific Antigen ◽

The Relationship

Download Full-text

Tissue Zinc Concentration in Prostate Cancer: Relationship with Prostate Specific Antigen and Gleason Score in a Cohort of Nigerian Men

Asian Pacific Journal of Cancer Biology ◽

10.31557/apjcb.2021.6.2.147-153 ◽

2021 ◽

Vol 6 (2) ◽

pp. 147-153

Author(s):

Martin Igbokwe ◽

Ayo Salako ◽

Tajudeen Badmus ◽

Eusebius Obiajunwa ◽

Olalekan Olasehinde ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Specific Antigen ◽

Disease Severity ◽

Gleason Score ◽

Zinc Concentration ◽

Specific Antigen ◽

Control Group ◽

Cross Sectional ◽

Zn Concentration ◽

The Relationship

Introduction: Prostate cancer (PCa) is the commonest maliganacy among men of African descent. The possible role of trace elements like Zinc in its aetiogenesis and disease severity remains controversial. This paper aims to identify the relationship between tissue zinc concentration and the occurrence of prostate cancer. And to identify the relationship between the tissue zinc concentration and the disease severity (using the prostate specific antigen (PSA) and Gleason scores (GS)).Methodology: A cross-sectional study of 41 consecutive consenting men with histologically confirmed PCa and 41 age-matched controls. Toe-nail clippings were obtained from both groups and assayed for zinc using the Particle induced X-ray emission (PIXE) technique. Zinc concentrations were compared between cases and controls. A correlation analysis was performed to determine relationship between Zinc concentration and disease severity (PSA and GS). Results: Forty one men each were recruited in the Prostate cancer and control groups for this study. PCa group had a mean age of 72.83 ± 7.06 years while the control group was 70.73 ±6.40 years. There was statistically significant higher toe-nail Zn concentration among Prostate cancer patients than controls (P= 0.028, t=2.28, df=40). The mean PSA values among the Prostate cancer group was 46.10 ± 40.62ng/ml and mode GS was 8.There was neither a correlation between toe-nail Zn concentration and serum PSA levels (p=0.386) nor with the GS. Conclusion: This study found a statistically significant higher toe-nail Zn concentration among men with PCa compared with age-matched controls. There was however no correlation between toe-nail Zn concentration and the serum prostate specific antigen or Gleason score.

Download Full-text