Inhibition of Novel Reassortant Avian Influenza H7N9 Virus Infection in vitro with Three Antiviral Drugs, Oseltamivir, Peramivir and Favipiravir

2014 ◽  
Vol 23 (6) ◽  
pp. 237-240 ◽  
Author(s):  
Rui-Yuan Cao ◽  
Jun-Hai Xiao ◽  
Bin Cao ◽  
Song Li ◽  
Yohichi Kumaki ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
Antiviral Agents ◽  
H7n9 Virus ◽  
Avian Origin ◽  
Influenza H7n9 Virus ◽  
Virus Strains ◽  
Respiratory Specimens

Background: A novel reassortant avian-origin influenza A (H7N9) virus was isolated from respiratory specimens obtained from three patients and was identified as H7N9 in China. Antiviral agents are required to treat patients with avian influenza H7N9 virus infection. Methods: In this study, we assessed the antiviral potential of oseltamivir, peramivir, favipiravir (T-705), amantadine and rimantadine against novel reassortant avian-origin influenza H7N9 virus in vitro. Results: All three avian influenza H7N9 virus strains were sensitive to oseltamivir, peramivir and favipiravir (T-705), but resistant to amantadine and rimantadine. Conclusions: Our data show a pattern of antiviral sensitivity for this novel H7N9 strain of influenza that suggests the compounds oseltamivir, peramivir and favipiravir should be useful for therapy.

scholarly journals Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

Vaccine ◽  
2015 ◽  
Vol 33 (18) ◽  
pp. 2152-2158 ◽  
Author(s):  
Ye V. Liu ◽  
Michael J. Massare ◽  
Melissa B. Pearce ◽  
Xiangjie Sun ◽  
Jessica A. Belser ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Recombinant Virus ◽  
Protective Immunity ◽  
Influenza A ◽  
H7n9 Virus ◽  
Virus Like Particles

scholarly journals Avian Influenza A(H7N9) Virus Infection in Pregnant Woman, China, 2013

2014 ◽  
Vol 20 (2) ◽  
Author(s):  
Xian Qi ◽  
Lunbiao Cui ◽  
Ke Xu ◽  
Bin Wu ◽  
Fenyang Tang ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
H7n9 Virus

scholarly journals A Detailed Epidemiological and Clinical Description of 6 Human Cases of Avian-Origin Influenza A (H7N9) Virus Infection in Shanghai

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77651 ◽  
Author(s):  
Jindong Shi ◽  
Juan Xie ◽  
Zebao He ◽  
Yunwen Hu ◽  
Yanchao He ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A ◽  
H7n9 Virus ◽  
Avian Origin ◽  
Clinical Description

scholarly journals Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans

2020 ◽  
Vol 80 (3) ◽  
pp. 310-319 ◽  
Author(s):  
Junbo Chen ◽  
Huachen Zhu ◽  
Peter W. Horby ◽  
Qianli Wang ◽  
Jiaxin Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
Antibody Responses ◽  
H7n9 Virus

scholarly journals Comprehensive Characterization of Serum MicroRNA Profile in Response to the Emerging Avian Influenza A (H7N9) Virus Infection in Humans

Viruses ◽  
2014 ◽  
Vol 6 (4) ◽  
pp. 1525-1539 ◽  
Author(s):  
Zheng Zhu ◽  
Yuhua Qi ◽  
Aihua Ge ◽  
Yefei Zhu ◽  
Ke Xu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
H7n9 Virus ◽  
Serum Microrna ◽  
Microrna Profile ◽  
Comprehensive Characterization

scholarly journals Laboratory Diagnosis and Epidemiology of Avian Influenza A (H7N9) Virus Infection in Humans in Nanchang City, China

2013 ◽  
Vol 66 (6) ◽  
pp. 558-560 ◽  
Author(s):  
Xianfeng Zhou ◽  
Hui Li ◽  
Xiansheng Ni ◽  
Mingbin Liu ◽  
Maohong Hu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
Laboratory Diagnosis ◽  
H7n9 Virus

scholarly journals Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection

2018 ◽  
Vol 7 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Ming Tan ◽  
Lunbiao Cui ◽  
Xiang Huo ◽  
Ming Xia ◽  
Fengjuan Shi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
H7n9 Virus ◽  
Influenza H7n9 Virus

scholarly journals Treatment of Highly Pathogenic H7N9 Virus-Infected Mice with Baloxavir Marboxil

Viruses ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1066 ◽  
Author(s):  
Maki Kiso ◽  
Seiya Yamayoshi ◽  
Yuri Furusawa ◽  
Masaki Imai ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Influenza A ◽  
H7n9 Virus ◽  
Neuraminidase Inhibitors ◽  
Influenza A Viruses ◽  
Lethal Challenge ◽  
Highly Pathogenic ◽  
Limited Efficacy ◽  
H7n9 Influenza ◽  
Influenza H7n9 Virus

Viral neuraminidase inhibitors show limited efficacy in mice infected with H7N9 influenza A viruses isolated from humans. Although baloxavir marboxil protected mice from lethal challenge infection with a low pathogenic avian influenza H7N9 virus isolated from a human, its efficacy in mice infected with a recent highly pathogenic version of H7N9 human isolates is unknown. Here, we examined the efficacy of baloxavir marboxil in mice infected with a highly pathogenic human H7N9 virus, A/Guangdong/17SF003/2016. Treatment of infected mice with a single 1.5 mg/kg dose of baloxavir marboxil protected mice from the highly pathogenic human H7N9 virus infection as effectively as oseltamivir treatment at 50 mg/kg twice a day for five days. Daily treatment for five days at 15 or 50 mg/kg of baloxavir marboxil showed superior therapeutic efficacy, largely preventing virus replication in respiratory organs. These results indicate that baloxavir marboxil is a valuable candidate treatment for human patients suffering from highly pathogenic H7N9 virus infection.

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