scholarly journals An overview of respiratory syncytial virus infections in Saudi Arabia

2018 ◽  
Vol 12 (11) ◽  
pp. 929-936 ◽  
Author(s):  
Anwar Ahmed ◽  
Shama Parveen ◽  
Sarah M Al-Hassinah ◽  
Salman F. Al-Amery
Keyword(s):  
Saudi Arabia ◽  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Evolutionary Dynamics ◽  
Winter Season ◽  
Glycosylation Site ◽  
Viral Pathogen ◽  
Geographical Regions ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a major pathogen of acute respiratory tract infection (ARI) in different geographical regions including Saudi Arabia. Numerous hospital-based investigations have revealed the RSV prevalence between 0.2-54% in the paediatric population with ARI/ALRI from Saudi Arabia during 1991-2015. Maximum RSV infections occurred in children less than 1 year of age (51-97%) and male children (51-69%) were more commonly affected than females (31-49%). RSV infections are reported mostly during winter season suggesting seasonal distribution of the virus. Other respiratory viruses reported from this region are adenovirus, influenza, parainfluenza, human metapneumovirus and rhinovirus including many mixed infections. A few studies have reported the phylogenetic analysis of the circulating strains of RSV. These studies have revealed that circulating group A-RSV Saudi strains belonged to NA1 and ON1 genotypes and group B-RSV viruses clustered in the BA genotype. Molecular characterization of the Saudi strains was further carried out by mutational, selection pressure and glycosylation site analyses. We have compiled all the eighteen studies of RSV infection from Saudi Arabia in the form of this review and concluded that detailed comprehensive surveillance of RSV and other viruses in community and hospital settings is required. Information on the molecular characterization of currently circulating strains of RSV will contribute towards better understanding of the epidemiology and evolutionary dynamics of this viral pathogen. Moreover, the determination of the genetic composition of circulating RSV strains will be important during evaluation of initial vaccine trials.

scholarly journals Correction: Molecular Characterization of Circulating Respiratory Syncytial Virus (RSV) Genotypes in Gilgit Baltistan Province of Pakistan during 2011–2012 Winter Season

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145599
Author(s):  
Uzma Bashir Aamir ◽  
Muhammad Masroor Alam ◽  
Hajra Sadia ◽  
Syed Sohail Zahoor Zaidi ◽  
Birjees Mazher Kazi
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Winter Season ◽  
Syncytial Virus ◽  
Gilgit Baltistan

scholarly journals Molecular Characterization of Circulating Respiratory Syncytial Virus (RSV) Genotypes in Gilgit Baltistan Province of Pakistan during 2011-2012 Winter Season

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74018 ◽  
Author(s):  
Uzma Bashir Aamir ◽  
Muhammad Masroor Alam ◽  
Hajra Sadia ◽  
Syed Sohail Zahoor Zaidi ◽  
Birjees Mazher Kazi
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Winter Season ◽  
Syncytial Virus ◽  
Gilgit Baltistan

Molecular characterization of the glycoprotein and fusion protein in human respiratory syncytial virus subgroup A: Emergence of ON-1 genotype in Iran

2019 ◽  
Vol 71 ◽  
pp. 166-178 ◽  
Author(s):  
Somayeh Shatizadeh Malekshahi ◽  
Shaghayegh Razaghipour ◽  
Yazdan Samieipoor ◽  
Farhad B. Hashemi ◽  
Ali Akbar Rahbari Manesh ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Fusion Protein ◽  
Molecular Characterization ◽  
Human Respiratory Syncytial Virus ◽  
Syncytial Virus

scholarly journals Molecular characterization of circulating respiratory syncytial virus genotypes in Pakistani children, 2010–2013

2020 ◽  
Vol 13 (3) ◽  
pp. 438-445 ◽  
Author(s):  
Uzma Bashir Aamir ◽  
Muhammad Salman ◽  
Nadia Nisar ◽  
Nazish Badar ◽  
Mohammad Masroor Alam ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Virus Genotypes ◽  
Syncytial Virus

scholarly journals Molecular Characterization of a Nosocomial Outbreak of Human Respiratory Syncytial Virus on an Adult Leukemia/Lymphoma Ward

1999 ◽  
Vol 180 (5) ◽  
pp. 1686-1689 ◽  
Author(s):  
Tony Mazzulli ◽  
Teresa C. T. Peret ◽  
Allison McGeer ◽  
Darlene Cann ◽  
Kelly S. MacDonald ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Human Respiratory Syncytial Virus ◽  
Nosocomial Outbreak ◽  
Syncytial Virus ◽  
Adult Leukemia

Molecular characterization of human respiratory syncytial virus, 2010-2011: identification of genotype ON1 and a new subgroup B genotype in Thailand

2013 ◽  
Vol 159 (3) ◽  
pp. 499-507 ◽  
Author(s):  
Vichtavat Auksornkitti ◽  
Nichaphat Kamprasert ◽  
Siwanat Thongkomplew ◽  
Kamol Suwannakarn ◽  
Apiradee Theamboonlers ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Human Respiratory Syncytial Virus ◽  
Syncytial Virus

scholarly journals Circulation of Indigenous Bovine Respiratory Syncytial Virus Strains in Turkish Cattle: The First Isolation and Molecular Characterization

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1700
Author(s):  
Zafer Yazici ◽  
Emre Ozan ◽  
Cuneyt Tamer ◽  
Bahadir Muftuoglu ◽  
Gerald Barry ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Molecular Characterization ◽  
Beef Cows ◽  
Bovine Respiratory Syncytial Virus ◽  
Molecular Characteristics ◽  
Specific Primers ◽  
Antigen Elisa ◽  
Syncytial Virus ◽  
Virus Strains

Bovine respiratory disease (BRD) is a huge economic burden on the livestock industries of countries worldwide. Bovine respiratory syncytial virus (BRSV) is one of the most important pathogens that contributes to BRD. In this study, we report the identification and first isolation, with molecular characterization, of a new BRSV strain from lung specimens of three beef cows in Turkey that died from respiratory distress. After the screening of lung tissues for BRD-associated viruses using a multiscreen antigen-ELISA, a BRSV antigen was detected. This was then confirmed by real-time RT-PCR specific for BRSV. Following confirmation, virus isolation was conducted in MDBK cell cultures and clear CPE, including syncytia compatible with BRSV, were detected. RT-nested PCR, using F gene-specific primers, was performed on the cultured isolates, and the products were sequenced and deposited to Genbank with accession numbers MT179304, MT024766, and MT0244767. Phylogenetic analysis of these sequences indicated that the cattle were infected with BRSV from subgroup III and were closely related to previously identified American and Turkish strains, but contained some amino acid and nucleotide differences. This research paves the way for further studies on the molecular characteristics of natural BRSV isolates, including full genome analysis and disease pathogenesis, and also contributes to the development of robust national strategies against this virus.

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