nosocomial outbreak
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2022 ◽  
Vol 12 ◽  
Author(s):  
Lang Yang ◽  
Hong He ◽  
Qichao Chen ◽  
Kaiying Wang ◽  
Yanfeng Lin ◽  
...  

NDM-1-producing multidrug-resistant Proteus mirabilis brings formidable clinical challenges. We report a nosocomial outbreak of carbapenem-resistant P. mirabilis in China. Six P. mirabilis strains collected in the same ward showed close phylogenetic relatedness, indicating clonal expansion. Illumina and MinION sequencing revealed that three isolates harbored a novel Salmonella genomic island 1 carrying a blaNDM–1 gene (SGI1-1NDM), while three other isolates showed elevated carbapenem resistance and carried a similar SGI1 but with two blaNDM–1 gene copies (SGI1-2NDM). Four new single nucleotide mutations were present in the genomes of the two-blaNDM–1-harboring isolates, indicating later emergence of the SGI1-2NDM structure. Passage experiments indicated that both SGI variants were stably persistent in this clone without blaNDM–1 copy number changes. This study characterizes two novel blaNDM–1-harboring SGI1 variants in P. mirabilis and provides a new insight into resistance gene copy number variation in bacteria.


Author(s):  
Liliana Clara ◽  
María Ines Staneloni ◽  
Estela Salazar ◽  
Graciela Greco ◽  
Mariangeles Visus ◽  
...  
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2021 ◽  
Vol 50 (1) ◽  
pp. 36-36
Author(s):  
Alexandra Schaller ◽  
Samir Shah ◽  
Rebekah Shappley ◽  
Nicholas Hysmith ◽  
Alisha Clark ◽  
...  

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1426
Author(s):  
Cécile Emeraud ◽  
Samy Figueiredo ◽  
Rémy A. Bonnin ◽  
Mouna Khecharem ◽  
Souad Ouzani ◽  
...  

Infections caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) are constantly rising worldwide and are often reported as causative agent of outbreaks in intensive care units (ICUs). During the first wave of the COVID-19 pandemic, bacterial cross-transmission was thought unlikely to occur due to the reinforcement of hygiene measures and prevention control. However, we report here an ESBL-producing K. pneumoniae (ST394) isolate responsible for a nosocomial outbreak in an ICU dedicated to COVID-19 patients.


2021 ◽  
Vol 117 ◽  
pp. 124-134 ◽  
Author(s):  
M. Abbas ◽  
T. Robalo Nunes ◽  
A. Cori ◽  
S. Cordey ◽  
F. Laubscher ◽  
...  

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