Febrile urticaria in a family: uncommon manifestation of a common disease

Cutaneous manifestations are uncommon with malaria. These include urticaria, purpura fulminans, and petechial rash. We report on a series of three patients from a single family who had an urticarial rash with fever that was subsequently diagnosed to be caused by malaria. Urticarial rash has been previously reported with both falciparum and vivax malaria infections. Although the exact pathogenesis is not clear urticarial rash might be related with IgE mediated mast cell degranulation.

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Inhibition of IgE-mediated mast cell degranulation by sulphasalazine

European Journal of Pharmacology ◽

10.1016/0014-2999(85)90071-8 ◽

1985 ◽

Vol 107 (2) ◽

pp. 279-281 ◽

Cited By ~ 30

Author(s):

Kim E. Barrett ◽

Tracy L. Tashof ◽

Dean D. Metcalfe

Keyword(s):

Mast Cell ◽

Mast Cell Degranulation ◽

Ige Mediated

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IgE-mediated mast cell degranulation and recovery monitored by time-lapse photography☆

Journal of Allergy and Clinical Immunology ◽

10.1067/mai.2001.116124 ◽

2001 ◽

Vol 108 (1) ◽

pp. 116-121 ◽

Cited By ~ 41

Author(s):

Zou Xiang ◽

Mats Block ◽

Carl Löfman ◽

Gunnar Nilsson

Keyword(s):

Mast Cell ◽

Time Lapse ◽

Mast Cell Degranulation ◽

Ige Mediated ◽

Time Lapse Photography

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SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Scientific Reports ◽

10.1038/s41598-017-01121-8 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 4

Author(s):

Hanna Pettersson ◽

Behdad Zarnegar ◽

Annika Westin ◽

Viktor Persson ◽

Christiane Peuckert ◽

...

Keyword(s):

Mast Cell ◽

Mast Cell Degranulation ◽

Ige Mediated

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Denatonium Benzoate Exposure Promotes IgE-Mediated Mast Cell Degranulation and Allergy By Upregulating FcεRIα Expression

10.21203/rs.3.rs-885618/v1 ◽

2021 ◽

Author(s):

Huaping Xu ◽

Xiaoyun Shi ◽

Mengting Xie ◽

Shiyu Xiao ◽

Xin Li ◽

...

Keyword(s):

Mast Cell ◽

Mast Cells ◽

Cell Surface ◽

Surface Expression ◽

Specific Ige ◽

Mast Cell Degranulation ◽

Cell Surface Expression ◽

Denatonium Benzoate ◽

Ige Mediated

Abstract Background: Denatonium benzoate (DB), one of the bitterest compounds known to man, is currently added to a wide range of products and is also used for alcohol denaturation. Some reports demonstrated that asthmatic symptoms are associated with DB exposure but the possible links between DB and IgE-mediated allergy susceptibility have not been examined to date. We investigated the effects of DB on IgE-mediated mast cell degranulation in vitro and in the ovalbumin (OVA)-induced mouse model of allergy.Methods: DB treatments were given to RBL-2H3 IgE-sensitized rat mast cell/basophil cells and KU812 human basophilic cells together with OVA-induced allergic BALB/c mice. Allergic mediator release, Ca2+ influx and OVA-specific IgE anaphylactic shock symptoms were measured along with the cell-surface expression of the α-subunit of high-affinity IgE receptor FcεRI on mast cells.Results: DB increases β-hexosaminidase (β-hex) release and Ca2+ mobilization in IgE-mediated activated RBL-2H3 and KU812 cells, and enhanced the cell-surface expression of FcεRIα. DB also promoted the severity of OVA-induced anaphylactic and diarrheic symptoms which was accompanied by mucus thickness in jejunum and the levels of β-hex, histamine and OVA-specific IgE in allergy mice, as well as the levels of FcεRIα mRNA and the FcεRIα proteinin isolated mucosal mast cells. Conclusions: DB treatments can promote the IgE-mediated mast cell degranulation in vitro and OVA-induced allergic susceptibility in mice by upregulating mast-cell-surface FcεR1α expression, providing evidence for DB exposure in promoting allergy susceptibility.

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