scholarly journals Serological pattern of anti-HBc alone infers occult hepatitis B virus infection in high-risk individuals in Iran

2010 ◽  
Vol 4 (10) ◽  
pp. 658-661 ◽  
Author(s):  
Amitis Ramezani ◽  
Mohammad Banifazl ◽  
Ali Eslamifar ◽  
Arezoo Aghakhani
Keyword(s):  
High Risk ◽  
Hepatitis B ◽  
Blood Donors ◽  
Low Risk ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hepatitis ◽  
Occult Hbv ◽  
B Virus ◽  
Risk Patients

Introduction: Anti-hepatitis B core antibody (Anti-HBc) alone is defined as the presence of anti-HBc in the absence of HBsAg and anti-HBs. The significance of this serological pattern as a predicting factor for occult hepatitis B virus (HBV) infection remains largely unknown. This study aimed to assess the significance of anti-HBc alone in predicting occult HBV infection in high-risk and low-risk individuals. Methodology: A total of 926 individuals were enrolled in this study, including 289 hemodialysis (HD) and 106 HIV-infected patients who were considered as a high-risk group and 531 blood donors who were considered as low-risk. HBsAg, anti-HBs, anti-HBc were tested in all subjects. The presence of HBV-DNA was determined quantitatively in patients with anti-HBc alone by real-time PCR. Results: Of the 395 high-risk patients, 40 cases (10.13%) had anti-HBc alone, while 11 subjects (2.07%) out of 531 blood donors had anti-HBc alone. HBV-DNA was detected in 12 out of 40 (30%) high-risk patients and none of the blood donors with anti-HBc alone. Conclusion: Our study showed that the serological pattern of anti-HBc alone could reflect occult HBV infection in high risk cases but did not presume occult HBV infection in low-risk individuals.

scholarly journals Transmissibility of Hepatitis B Virus (HBV) Infection through Blood Transfusion from Blood Donors with Occult HBV Infection

2011 ◽  
Vol 52 (5) ◽  
pp. 624-632 ◽  
Author(s):  
M.-F. Yuen ◽  
D. Ka-Ho Wong ◽  
C.-K. Lee ◽  
Y. Tanaka ◽  
J.-P. Allain ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China

Transfusion ◽  
2017 ◽  
Vol 57 (3pt2) ◽  
pp. 857-866 ◽  
Author(s):  
Hao Liao ◽  
Yan Liu ◽  
Jianhong Chen ◽  
Weiping Ding ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
North China ◽  
Blood Donors ◽  
Gene Mutations ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

Hepatitis B virus infection in blood donors in Argentina: prevalence of infection, genotype distribution and frequency of occult HBV infection

2016 ◽  
Vol 161 (10) ◽  
pp. 2813-2817 ◽  
Author(s):  
María Belén Pisano ◽  
Sebastián Blanco ◽  
Horacio Carrizo ◽  
Viviana Elizabeth Ré ◽  
Sandra Gallego
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hbv Infection ◽  
Genotype Distribution ◽  
Hepatitis B Virus Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals Prevalence of overt and occult hepatitis B virus infections among 135 haemodialysis patients attending a haemodialysis centre at Al-Nasiriyah city, Iraq

2020 ◽  
Author(s):  
Muslim Dhahr Musa ◽  
Hekmat Kadhum Ateya
Keyword(s):  
Viral Load ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Real Time ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hepatitis ◽  
Occult Hbv ◽  
B Virus ◽  
Occult Hepatitis B

Background and Objectives: The prevalence of Hepatitis B virus (HBV) infection among haemodialysis (HD) patients has been well documented. In addition to overt infection, occult Hepatitis B infection exists in which a patient who is diagnosed seronegative for Hepatitis B surface antigen (HBsAg) shows positive HBV-DNA on using more accurate molecular methods. This study aims to determine the prevalence of overt and occult HBV infection among the HD patients who had attended Al-Nasiriyah dialysis centre during a two-month period. Materials and Methods: Serological qualitative detection of HBsAg by rapid test (strips), enzyme immunoassay (EIA, HBsAg) and molecular (real-time polymerase chain reaction (real-time PCR)) was conducted for quantitative detection of HBV in HD patients’ serum. Results: The prevalence of overt HBV infection among HD patients was 3.7%. The viral load of HBV positive patients was ranging from 5.85 × 101 to 2.16 × 106 copies/ml of serum with median (7.4 × 105 copies/ml). Occult Hepatitis B was not detected in any of the seronegative HD patients (0%). Overt infection was found more in males (80%) than females (20%) (P<0.05). Similarly, infection was found to be higher among patients who had blood transfusions (80%) than those who had not (20%) with statistical significant p<0.05. Although not statistically significant, the mean duration of HD was higher among HBV positive HD patients (17.6) than HBV negative HD patients (14.3). A dual infection of HBV and HCV was not detected in this study. Conclusion: Nosocomial transmissions at HD centres and blood transfusion are important risk factors. Besides serological screening, real-time PCR offers a safeguard against the spread of overt and occult HBV infection and determines the viral load of the positive patients.

A new method of concentrating hepatitis B virus (HBV) DNA and HBV surface antigen: an application of the method to the detection of occult HBV infection

Vox Sanguinis ◽  
2008 ◽  
Vol 95 (3) ◽  
pp. 174-180 ◽  
Author(s):  
K. Satoh ◽  
A. Iwata-Takakura ◽  
A. Yoshikawa ◽  
Y. Gotanda ◽  
T. Tanaka ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hbv Dna ◽  
Hbv Infection ◽  
New Method ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals Development of occult hepatitis B viral infection in pregnancy: implications for antenatal screening in women from endemic areas

2010 ◽  
Vol 3 (3) ◽  
pp. 115-118
Author(s):  
Philip Chang ◽  
Jeffrey Tu ◽  
Antony Chesterman ◽  
Robert Kim ◽  
Peter Robertson ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Vertical Transmission ◽  
Peripheral Blood ◽  
Hbv Dna ◽  
Hbv Infection ◽  
Antenatal Screening ◽  
Occult Hbv Infection ◽  
Occult Hepatitis ◽  
Occult Hbv ◽  
Occult Hepatitis B

Occult hepatitis B virus (HBV) infection, manifest clinically by the presence of HBV deoxyribonucleic acid (HBV DNA) in peripheral blood in individuals who test negative for the HBV surface antigen (HBsAg), may occur in various clinical contexts, including under the influence of pharmacological immunosuppression in patients from areas endemic for HBV and, hence, at risk of previous exposure. Pregnancy is a condition associated with immune suppression, but whether virus-specific immunity may be suppressed to an extent sufficient to allow occult HBV infection to develop is currently unknown. This is potentially relevant not only to the mother's health but also because vertical transmission has been reported in the occult HBV infection setting. We report a 30-year-old woman from a country endemic for HBV who, prior to pregnancy, was persistently HBsAg-negative with undetectable HBV DNA in peripheral blood, in whom HBV DNA became increasingly detectable during pregnancy, peaking in the third trimester, before returning to undetectable levels postpartum. HBsAg remained negative and liver function tests were normal throughout. Immunoglobulin M hepatitis B core antibody, a marker of the possibility of acquisition of a new HBV infection, was also negative. The baby received immunization against HBV infection from birth and has remained HBV negative at six months. This report documents for the first time that occult HBV infection may develop during pregnancy. Further data are required regarding the prevalence of this phenomenon, predisposing factors, impact on maternal health and risk of vertical transmission so that implications for current antenatal screening strategies that do not include measurement of HBV DNA in peripheral blood can be properly determined.

scholarly journals Hepatitis B virus genotype, HBsAg mutations and co-infection with HCV in occult HBV infection

2011 ◽  
Vol 35 (8-9) ◽  
pp. 554-559 ◽  
Author(s):  
M.K. Arababadi ◽  
A.A. Pourfathollah ◽  
A. Jafarzadeh ◽  
G. Hassanshahi ◽  
M. Salehi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Virus Genotype ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus
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