scholarly journals NMR-Studies of the Interaction of Metal Ions with Poly-(1,4-hexuronates). III. Proton Magnetic Resonance Study of the Binding of Lanthanides to Methyl alpha-D-Gulopyranoside in Aqueous Solution.

1975 ◽  
Vol 29b ◽  
pp. 17-21 ◽  
Author(s):  
H. Grasdalen ◽  
T. Anthonsen ◽  
B. Larsen ◽  
O. Smidsrød ◽  
O. Dahl ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Magnetic Resonance ◽  
Metal Ions ◽  
Proton Magnetic Resonance ◽  
Magnetic Resonance Study ◽  
Nmr Studies ◽  
Proton Magnetic Resonance Study

A Proton Magnetic Resonance Study of the Ultraviolet Photoproduct of d(TpT) in Aqueous Solution

1975 ◽  
Vol 53 (8) ◽  
pp. 1193-1203 ◽  
Author(s):  
Frank E. Hruska ◽  
Donald J. Wood ◽  
Kelvin K. Ogilvie ◽  
James L. Charlton
Keyword(s):  
Aqueous Solution ◽  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Chemical Shifts ◽  
Coupling Constants ◽  
Magnetic Resonance Study ◽  
Parent Molecule ◽  
Terminal Fragment ◽  
Proton Magnetic Resonance Study ◽  
Cyclobutane Ring

The p.m.r. data of d(TpT) and its predominant u.v. photoproduct d(T[p]T) in aqueous solution are compared. The data are consistent with the presence of a cis-syn cyclobutane ring in d(T[p]T). Consideration of the H1′ chemical shifts leads to the conclusion that changes in the sugar–base torsion angle of both nucleotide fragments of the parent molecule are required to bring the thymine bases into alignment for photodimerization. The coupling constants indicate that the conformation of the 5′-terminal fragment is only slightly affected by the cyclobutane ring formation. Photodimerization brings about a distortion of the sugar pucker in the 3′-terminal fragment. In this fragment both the gauche-gauche and gauche-trans conformers are significantly populated whereas the trans-gauche form is excluded.

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