scholarly journals Application of silk fibroin/chitosan/nano‑hydroxyapatite composite scaffold in the repair of rabbit radial bone defect

2017 ◽  
Author(s):  
Peng Ye ◽  
Bin Yu ◽  
Jiang Deng ◽  
Rong‑Feng She ◽  
Wen‑Liang Huang
Keyword(s):  
Bone Defect ◽  
Silk Fibroin ◽  
Composite Scaffold ◽  
Hydroxyapatite Composite ◽  
Radial Bone

scholarly journals Mechanical properties of Gelatin –Hydroxyapatite composite for bone tissue engineering

2015 ◽  
Vol 50 (1) ◽  
pp. 15-20 ◽  
Author(s):  
MJ Hossan ◽  
MA Gafur ◽  
MM Karim ◽  
AA Rana
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Testing Machine ◽  
Casting Process ◽  
Raw Material ◽  
Potential Candidate ◽  
Oven Drying ◽  
Hydroxyapatite Composite ◽  
Properties Of Composites

In this study, hydroxyapatite (HAp) and gelatin (GEL) scaffolds were prepared to mimic the mineral and organic component of natural bone. The raw material was first compounded and resulting composite were molded into the petridishes. Using Solvent casting process, it is possible to produce scaffolds with mechanical and structural properties close to natural trabecular bone.The mechanical properties of composites were investigated by Thermo-mechanical analyzer (TMA), Vickers microhardness tester, Universal testing machine. It was observed that the composite has maximum tensile strength of 37.13MPa ( oven drying) and % elongation of 7.68 (Oven drying) and 2.04 (Natural drying) at 15% of Hap respectively. These results demonstrate that the prepared composite scaffold is a potential candidate for bone tissue engineering.Bangladesh J. Sci. Ind. Res. 50(1), 15-20, 2015

PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits

2013 ◽  
Vol 9 (5) ◽  
pp. 6711-6722 ◽  
Author(s):  
S.-H. Chen ◽  
M. Lei ◽  
X.-H. Xie ◽  
L.-Z. Zheng ◽  
D. Yao ◽  
...  
Keyword(s):  
Bone Defect ◽  
Composite Scaffold ◽  
Bone Defect Repair ◽  
Defect Repair

scholarly journals Silk fibroin hydroxyapatite composite thermal stabilisation of carbonic anhydrase

2016 ◽  
Vol 4 ◽  
Author(s):  
Zhang Zishuai ◽  
Lopes Joao ◽  
Marelli Benedetto ◽  
Omenetto Forenzo ◽  
Kaplan David ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Silk Fibroin ◽  
Hydroxyapatite Composite

Design of a Collagen/Silk Mechano-Compatible Composite Scaffold for the Vascular Tissue Engineering: Focus on Compliance

2007 ◽  
Vol 334-335 ◽  
pp. 1169-1172 ◽  
Author(s):  
Frédéric Couet ◽  
Navneeta Rajan ◽  
Simone Vesentini ◽  
D. Mantovani
Keyword(s):  
Mechanical Properties ◽  
Silk Fibroin ◽  
Vascular Tissue ◽  
Composite Scaffold ◽  
Collagen Gel ◽  
Element Model ◽  
Natural Fibre ◽  
Filament Winding ◽  
Laminate Theory

One of the merging methods to produce tissue-engineered vascular substitutes is to process scaffolds to direct the regeneration of vascular tissues. Collagen, as one of the main protein in the vascular extracellular matrix, is one of biopolymers that exhibits a major potential for scaffold technology. However, gels made from reconstituted collagen generally exhibit poor mechanical properties and limited manipulability. Therefore, adding a reinforcement to the scaffold to make the structure resist to the physiological constraints applied during the regeneration represents a valid alternative. Silk fibroin is an interesting reinforcing candidate being a mechanically strong natural fibre, susceptible to proteolytic degradation in vivo and showing acceptable biological performances. Therefore, the aim of this study was to develop a model of a composite scaffold obtained by controlling the filament geometry winding of silk fibroin in the collagen gel. A finite element model taking into account the orthotropic elasticity of arteries has been combined with classic laminate theory applied to the filament winding of a tubular vessel. The design of the small structure susceptible to scaffold the vascular tissue regeneration was optimised by mean of an evolutive algorithm with the imperative to mimic the experimentally measured mechanical properties (compliance) of a native artery.

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