scholarly journals VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review)

2016 ◽  
Vol 49 (2) ◽  
pp. 437-447 ◽  
Author(s):  
Samanta Taurone ◽  
Filippo Galli ◽  
Alberto Signore ◽  
Enzo Agostinelli ◽  
Rudi A.J.O. Dierckx ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Clinical Application ◽  
Future Perspectives

scholarly journals Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry

2021 ◽  
Vol 22 (14) ◽  
pp. 7410
Author(s):  
Matteo Mari ◽  
Debora Carrozza ◽  
Erika Ferrari ◽  
Mattia Asti
Keyword(s):  
Nuclear Medicine ◽  
Early Diagnosis ◽  
Clinical Application ◽  
Medicinal Chemistry ◽  
Biological Properties ◽  
Present Review ◽  
Chemical Modifications ◽  
Technetium 99M ◽  
Curcumin Derivatives ◽  
Gallium 68

Curcumin is a natural occurring molecule that has aroused much interest among researchers over the years due to its pleiotropic set of biological properties. In the nuclear medicine field, radiolabelled curcumin and curcumin derivatives have been studied as potential radiotracers for the early diagnosis of Alzheimer’s disease and cancer. In the present review, the synthetic pathways, labelling methods and the preclinical investigations involving these radioactive compounds are treated. The studies entailed chemical modifications for enhancing curcumin stability, as well as its functionalisation for the labelling with several radiohalogens or metal radionuclides (fluorine-18, technetium-99m, gallium-68, etc.). Although some drawbacks have yet to be addressed, and none of the radiolabelled curcuminoids have so far achieved clinical application, the studies performed hitherto provide useful insights and lay the foundation for further developments.

scholarly journals Planning of Nuclear Medicine in Turkey: Current Status and Future Perspectives

2012 ◽  
Vol 13 (5) ◽  
pp. 1989-1994
Author(s):  
Fatih Goksel ◽  
Irfan Peksoy ◽  
Orhan Koc ◽  
Murat Gultekin ◽  
Nejat Ozgul ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Current Status ◽  
Future Perspectives

Possibilities of Software Phantoms for Quality Control of KBS in Nuclear Medicine

1992 ◽  
Vol 31 (02) ◽  
pp. 126-134 ◽  
Author(s):  
K. Kotzke ◽  
D.-P. Pretschner
Keyword(s):  
Quality Control ◽  
Nuclear Medicine ◽  
Clinical Application ◽  
Test Data ◽  
Real Data ◽  
Analysis Data ◽  
Basic Requirement ◽  
Knowledge Based System ◽  
Knowledge Based ◽  
Large Numbers

Abstract:The assessment of the results of a “knowledge-based system” (KBS) for quality control is a basic requirement for clinical application: Large numbers of test studies are necessary in order to cover as widely as possible the spectrum of cases to be analyzed by the KBS. The use of original patient data as test data is one possibility, but real data are provided unevenly. This is due to the set of characteristics which are relevant to the analysis. Data are available in a limited quantity only. This implies a remaining set of unvalidated cases which are not represented in the data pool. The software phantom is an approach towards systematically guided validation. It permits the generation of test data adjusted to the demands of the validation.

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