Induction of p53 DNA-binding activity by tumor necrosis factor-alpha

1996 ◽  
Author(s):  
T Mukhopadhyay ◽  
J Roth ◽  
S Maxwell
Keyword(s):  
Tumor Necrosis Factor ◽  
Dna Binding ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Binding Activity ◽  
Necrosis Factor Alpha ◽  
Dna Binding Activity ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury

1994 ◽  
Vol 267 (4) ◽  
pp. G552-G561 ◽  
Author(s):  
A. M. Diehl ◽  
M. Yin ◽  
J. Fleckenstein ◽  
S. Q. Yang ◽  
H. Z. Lin ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Injury ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Binding Activity ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

After liver injury, remaining hepatocytes proliferate to regenerate the liver. Although the precise mechanisms that initiate and localize regeneration are unknown, local induction of c-jun is a critical, early step in the response. Treatment of rats with antibodies to tumor necrosis factor-alpha (TNF-alpha), a mediator of liver injury, inhibits regenerative induction of jun nuclear kinase activity and nuclear c-jun expression and alters the DNA binding activity of the c-jun transcription factor, AP-1, in liver. Pretreatment with anti-TNF antibodies does not affect pulmonary or renal c-jun expression or AP-1 binding activity post-partial hepatectomy. In primary hepatocyte cultures, TNF-alpha directly promotes the proliferative actions of mitogens, supporting in vivo evidence that it sensitizes hepatocytes to mitogens. Thus local release of TNF may act in a paracrine fashion to initiate regeneration in the injured liver by promoting induction of critical growth-related genes, such as c-jun.

The role of interleukin-6 and tumor necrosis factor alpha gene in fat and bone communication

2016 ◽  
Author(s):  
Chunyu Wang ◽  
Li Tian ◽  
Kun Zhang ◽  
Yaxi Chen ◽  
Xiang Chen ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Alpha Gene ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document