scholarly journals Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa

2015 ◽  
Vol 13 (1) ◽  
pp. 130-136 ◽  
Author(s):  
OLIVIA HERD ◽  
FLAVIA FRANCIES ◽  
JEFFREY KOTZEN ◽  
TRUDY SMITH ◽  
ZWIDE NXUMALO ◽  
...  
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Cancer Patients ◽  
Immunodeficiency Virus

Reduction in prevalence of invasive cervical cancer in KwaZulu-Natal, South Africa: impact of the human immunodeficiency virus epidemic

2006 ◽  
Vol 16 (3) ◽  
pp. 1036-1040
Author(s):  
M. Moodley
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Invasive Cervical Cancer ◽  
Epidemiologic Data ◽  
Kwazulu Natal ◽  
Immunodeficiency Virus ◽  
Time Periods ◽  
Sub Saharan

The bulk of the human immunodeficiency virus (HIV) pandemic continues to ravage the developing world, especially sub-Saharan countries. The HIV seroprevalence among women with invasive cervical cancer varies in different parts of the world. A comparison of women with cervical cancer was undertaken for epidemiologic data in the province of KwaZulu-Natal, South Africa, which has the highest HIV prevalence. The two time periods of study were 1999 and 2003. The aim was to determine the trends of prevalence of invasive cervical cancer and HIV infection among such women. While the background prevalence of HIV infection among women with invasive cervical cancer in our setting has remained constant over the two time periods (21% and 21.8%), there has been a significant reduction in the number of women presenting with invasive cervical cancer to our center (672 to 271) over the two time periods, with no changes in other variables. On the contrary, the prevalence of HIV infection among antenatal attendees had risen from 32.5% to 38.5% in the 1999 and 2003 periods, respectively. Reasons for this dramatic trend are presented together with other epidemiologic data.

scholarly journals Abnormal cervical cytology amongst women infected with human immunodeficiency virus in Limpopo province, South Africa

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Samuel T. Ntuli ◽  
Eric Maimela ◽  
Linda Skaal ◽  
Mabina Mogale ◽  
Provia Lekota
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Limpopo Province ◽  
Cervical Cytology ◽  
Hiv Positive ◽  
Abnormal Cytology ◽  
Abnormal Cervical Cytology ◽  
Hiv Positive Women ◽  
Immunodeficiency Virus

Background: Cervical cancer remains the major public problem worldwide and the most common gynaecological malignancy in the developing world, particularly in sub-Saharan Africa.Aim: To determine the prevalence of abnormal cervical cytology amongst women with and without human immunodeficiency virus (HIV) and examine the association between HIV and histological grading.Setting: The study was conducted in Limpopo province, which is the northernmost province of South Africa. The province has five district municipalities with one tertiary, five regional and thirty four district hospitals.Methods: We retrospectively reviewed cervical cancer cases in Limpopo province (LP) of South Africa, using data collected routinely by the National Health Laboratory Services (NHLS). The data on smears submitted for cytology between 2013 and 2015 were extracted from the Central Data Warehouse (CDW) database.Results: A total of 84 466 women were screened for cervical cytology smears. Their mean age was 39.8 ± 13.6 years, with range from 15 to 113 years; 77.2% were in the age group 30 years and older and 19.6% had an abnormal cervical cytology result. Overall, 46.4% of the women screened for cervical cancer were HIV infected. A significantly higher proportion of HIV-positive women had abnormal cytology than HIV-negative women (31.8% vs. 9.2%).Conclusion: The prevalence of abnormal cytology amongst HIV-positive women is relatively high, and the risk appears to be significantly greater in all age groups. This finding highlights the need to ascertain HIV status of all women presenting with cervical cancer.

Radical hysterectomy for cervical cancer amongst women infected with the human immunodeficiency virus

2007 ◽  
Vol 17 (6) ◽  
pp. 1264-1265 ◽  
Author(s):  
M. Moodley
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Radical Hysterectomy ◽  
Early Stage ◽  
Invasive Cervical Cancer ◽  
Cervical Lesions ◽  
Stage Disease ◽  
Immunodeficiency Virus ◽  
Late Stage Disease

Invasive cervical cancer and human immunodeficiency virus (HIV) infection are an epidemic in South Africa. Most HIV-infected patients with cervical cancer present with late-stage disease. Whilst the literature describes the outcome of such women with preneoplastic cervical lesions, the management of early-stage invasive cervical cancer and HIV is lacking. We present our experience with such patients

scholarly journals Promoter Hypermethylation Analysis of Host Genes in Cervical Cancer Patients With and Without Human Immunodeficiency Virus in Botswana

2021 ◽  
Vol 11 ◽  
Author(s):  
Leabaneng Tawe ◽  
Surbhi Grover ◽  
Nicola Zetola ◽  
Erle S. Robertson ◽  
Simani Gaseitsiwe ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Promoter Methylation ◽  
Invasive Cervical Cancer ◽  
Cancer Stage ◽  
Hiv Status ◽  
Immunodeficiency Virus ◽  
Host Genes

Background: Epidemics of human immunodeficiency virus (HIV) and cervical cancer are interconnected. DNA hypermethylation of host genes' promoter in cervical lesions has also been recognized as a contributor to cervical cancer progression.Methods: For this purpose we analyzed promoter methylation of four tumor suppressor genes (RARB, CADM1, DAPK1 and PAX1) and explored their possible association with cervical cancer in Botswana among women of known HIV status. Overall, 228 cervical specimens (128 cervical cancers and 100 non-cancer subjects) were used. Yates-corrected chi-square test and Fisher's exact test were used to explore the association of promoter methylation for each host gene and cancer status. Subsequently, a logistic regression analysis was performed to find which factors, HIV status, high risk-HPV genotypes, patient's age and promoter methylation, were associated with the following dependent variables: cancer status, cervical cancer stage and promoter methylation rate.Results: In patients with cervical cancer the rate of promoter methylation observed was greater than 64% in all the genes studied. Analysis also showed a higher risk of cervical cancer according to the increased number of methylated promoter genes (OR = 6.20; 95% CI: 3.66–10.51; P < 0.001). RARB methylation showed the strongest association with cervical cancer compared to other genes (OR = 15.25; 95% CI: 6.06–40.0; P < 0.001). Cervical cancer and promoter methylation of RARB and DAPK1 genes were associated with increasing age (OR = 1.12; 95% CI: 1.01-1.26; P = 0.037 and OR = 1.05; 95% CI: 1.00-1.10; P = 0.040). The presence of epigenetic changes at those genes appeared to be independent of HIV status among subjects with cervical cancer. Moreover, we found that cervical cancer stage was influenced by RARB (χ2= 7.32; P = 0.002) and CADM1 (χ2=12.68; P = 0.013) hypermethylation, and HIV status (χ2= 19.93; P = 0.001).Conclusion: This study confirms the association between invasive cervical cancer and promoter gene methylation of tumor suppressing genes at the site of cancer. HIV infection did not show any association to methylation changes in this group of cervical cancer patients from Botswana. Further studies are needed to better understand the role of HIV in methylation of host genes among cancer subjects leading to cervical cancer progression.

Sign in / Sign up

Export Citation Format

Share Document