scholarly journals Expression of hepatocyte markers in mass-forming peripheral and periductal-infiltrating hilar intrahepatic cholangiocarcinomas

2011 ◽  
Vol 2 (6) ◽  
pp. 1041-1046 ◽  
Author(s):  
HIROYA IIDA ◽  
MASAKI HATA ◽  
AYAKO KAKUNO ◽  
HIROSHI HIRANO ◽  
KOJI YAMANEGI ◽  
...  
Keyword(s):  
Hepatocyte Markers ◽  
Intrahepatic Cholangiocarcinomas

Immunohistochemically Detected Expression of p27Kip1 and Skp2 Predicts Survival in Patients with Intrahepatic Cholangiocarcinomas

2008 ◽  
Vol 16 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Nozomi Hashimoto ◽  
Shinichi Yachida ◽  
Keiichi Okano ◽  
Hisao Wakabayashi ◽  
Katsumi Imaida ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinomas

scholarly journals Expression of Hepatocyte Markers in Wharton’s Jelly Mesenchymal Stem Cells Using Mouse Liver Cell Extract

2017 ◽  
Vol 5 (2) ◽  
pp. 1-8
Author(s):  
Maryam Borhani-Haghighi ◽  
◽  
Fatemeh Alipour ◽  
Arezou Eshaghabadi ◽  
◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Cell ◽  
Mouse Liver ◽  
Cell Extract ◽  
Wharton’S Jelly ◽  
Wharton's Jelly ◽  
Mouse Liver Cell ◽  
Hepatocyte Markers

scholarly journals Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 964 ◽  
Author(s):  
Tracey Hurrell ◽  
Vlasia Kastrinou-Lampou ◽  
Achilleas Fardellas ◽  
Delilah F. G. Hendriks ◽  
Åsa Nordling ◽  
...  
Keyword(s):  
Human Liver ◽  
Progressive Disease ◽  
Human Hepatocytes ◽  
Alcoholic Fatty Liver ◽  
Drug Candidates ◽  
Alk5 Inhibitor ◽  
Hepatocyte Markers ◽  
Parenchymal Cells ◽  
Oxidant Effect ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease affects approximately one billion adults worldwide. Non-alcoholic steatohepatitis (NASH) is a progressive disease and underlies the advancement to liver fibrosis, cirrhosis, and hepatocellular carcinoma, for which there are no FDA-approved drug therapies. We developed a hetero-cellular spheroid system comprised of primary human hepatocytes (PHH) co-cultured with crude fractions of primary human liver non-parenchymal cells (NPC) from several matched or non-matched donors, to identify phenotypes with utility in investigating NASH pathogenesis and drug screening. Co-culture spheroids displayed stable expression of hepatocyte markers (albumin, CYP3A4) with the integration of stellate (vimentin, PDGFRβ), endothelial (vWF, PECAM1), and CD68-positive cells. Several co-culture spheroids developed a fibrotic phenotype either spontaneously, primarily observed in PNPLA3 mutant donors, or after challenge with free fatty acids (FFA), as determined by COL1A1 and αSMA expression. This phenotype, as well as TGFβ1 expression, was attenuated with an ALK5 inhibitor. Furthermore, CYP2E1, which has a strong pro-oxidant effect, was induced by NPCs and FFA. This system was used to evaluate the effects of anti-NASH drug candidates, which inhibited fibrillary deposition following 7 days of exposure. In conclusion, we suggest that this system is suitable for the evaluation of NASH pathogenesis and screening of anti-NASH drug candidates.

Intrahepatic cholangiocarcinomas mimicking other lesions

2015 ◽  
Vol 40 (7) ◽  
pp. 2345-2354 ◽  
Author(s):  
Sharon Z. Adam ◽  
Sudharshan Parthasarathy ◽  
Frank H. Miller
Keyword(s):  
Intrahepatic Cholangiocarcinomas

Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase–mutated intrahepatic cholangiocarcinomas

2018 ◽  
Vol 90 ◽  
pp. 83-91 ◽  
Author(s):  
Julia Delahousse ◽  
Loic Verlingue ◽  
Sophie Broutin ◽  
Clémence Legoupil ◽  
Mehdi Touat ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Surrogate Marker ◽  
Intrahepatic Cholangiocarcinomas

A Subset of Intrahepatic Cholangiocarcinomas Express Albumin RNA as Detected by In Situ Hybridization

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Vaidehi Avadhani ◽  
Cynthia Cohen ◽  
Momin T. Siddiqui ◽  
Alyssa Krasinskas
Keyword(s):  
In Situ Hybridization ◽  
Intrahepatic Cholangiocarcinomas

scholarly journals New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next‐Generation Sequencing

2014 ◽  
Vol 19 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Jeffrey S. Ross ◽  
Kai Wang ◽  
Laurie Gay ◽  
Rami Al‐Rohil ◽  
Janne V. Rand ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing ◽  
Intrahepatic Cholangiocarcinomas

scholarly journals Infrequent microsatellite instability in liver fluke infection-associated intrahepatic cholangiocarcinomas from Thailand

2003 ◽  
Vol 107 (3) ◽  
pp. 375-380 ◽  
Author(s):  
Upama Liengswangwong ◽  
Takayuki Nitta ◽  
Hironobu Kashiwagi ◽  
Hiroko Kikukawa ◽  
Toru Kawamoto ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Liver Fluke ◽  
Fluke Infection ◽  
Liver Fluke Infection ◽  
Intrahepatic Cholangiocarcinomas

Resin-based Yttrium-90 estimation as a prognostic factor for survival in patients with chemorefractory intrahepatic cholangiocarcinomas: a proof of concept study

2014 ◽  
Vol 25 (3) ◽  
pp. S106
Author(s):  
N. Kokabi ◽  
J.C. Camacho ◽  
M. Xing ◽  
D.M. Schuster ◽  
J. Galt ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Proof Of Concept ◽  
Concept Study ◽  
Yttrium 90 ◽  
Intrahepatic Cholangiocarcinomas
Sign in / Sign up

Export Citation Format

Share Document