scholarly journals Correlation of the expression of vascular endothelial growth factor and its receptors with microvessel density in ovarian cancer

2013 ◽  
Vol 6 (1) ◽  
pp. 175-180 ◽  
Author(s):  
LIMEI WANG ◽  
XIAOYAN LIU ◽  
HONG WANG ◽  
SHUHE WANG
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Microvessel Density ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer

2018 ◽  
Vol 69 (5) ◽  
pp. 1173-1178
Author(s):  
Laurentiu Pirtea ◽  
Dorin Grigoras ◽  
Cristina Secosan ◽  
Ioan Sas ◽  
Razvan Ilina ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Microvessel Density ◽  
Clinicopathological Parameters ◽  
Clinical Parameters ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Ovarian Carcinomas ◽  
Endothelial Growth Factor

Ovarian cancer malignancies have the worst prognosis among all gynecological malignancies. As angiogenesis represents a key step for tumor progression, vascular endothelial growth factor (VEGF) is one of the most discussed pro-angiogenic factors. VEGF expression was investigated in 62 cases of ovarian carcinomas. Microvessel density (MVD) was evaluated by correlating the results with clinical and histopathological parameters. Because of the controversial results reported in other studies, VEGF was assessed together with MVD. Our results suggest a more complex angiogenic mechanism in ovarian cancer based on the discrepancies between VEGF expression, microvessel density and their correlation with clinical parameters. The conflicting data arising from this study supports the implications of different growth factors, others than VEGF in ovarian cancer. This hypothesis is sustained by the lack of correlation between VEGF and clinical parameters, and by the significant correlation between microvessel density and clinicopathological parameters. Thus, further studies are needed for a complete evaluation of angiogenesis in ovarian cancer.

Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 241-246 ◽  
Author(s):  
V. Karavasilis ◽  
V. Malamou-Mitsi ◽  
E. Briasoulis ◽  
E. Tsanou ◽  
E. Kitsou ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Ovarian Carcinoma ◽  
Microvessel Density ◽  
Vascular Endothelial ◽  
Advanced Stage ◽  
Thrombospondin 1 ◽  
Treatment Research ◽  
Endothelial Growth Factor

The aim of the study was to investigate angiogenesis in patients with advanced-stage ovarian carcinoma. We used paraffin-embedded tumor tissues from 33 patients diagnosed with FIGO III ovarian cancer who had optimal surgery and received platinum-based chemotherapy. The tissue expression of CD34, vascular endothelial growth factor (VEGF), and thrombospondin-1 (TSP-1) was assessed immunohistochemically. CD34 stained hot spot areas were used to evaluate tumor microvessel density (MVD). VEGF and TSP-1 were assessed by semiquantitative methods. The studied molecules were investigated for relationship with standard clinicopathologic parameters. MVD count was high: median value of 39, range 12–143 microvessels/mm2. VEGF was present in all cases and stained strong in 91%. Stroma staining for TSP-1 was weak in 79% of the cases, strong in 6%, and absent in five (15%). We did not find correlations between the three studied markers and histologic type or tumor grade. MVD score did not relate to VEGF or TSP-1. We only observed a trend toward a longer survival in patients with tumors expressing high TSP-1 (60 vs. 36 months, P= 0.1). Proangiogenetic factor VEGF is highly expressed in advanced-stage ovarian carcinomas. The findings of this study may offer support for considering VEGF-targeted therapeutics in ovarian cancer treatment research.

scholarly journals Vascular Endothelial Growth Factor-165 Overexpression Stimulates Angiogenesis and Induces Cyst Formation and Macrophage Infiltration in Human Ovarian Cancer Xenografts

2002 ◽  
Vol 160 (2) ◽  
pp. 537-548 ◽  
Author(s):  
Monique C.A. Duyndam ◽  
Marion C.G.W. Hilhorst ◽  
Hennie M.M. Schlüper ◽  
Henk M. W. Verheul ◽  
Paul J. van Diest ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cyst Formation ◽  
Macrophage Infiltration ◽  
Human Ovarian Cancer ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Microvessel density in normal lymph nodes and lymphomas of dogs and their correlation with vascular endothelial growth factor expression

2008 ◽  
Vol 85 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Birgitt Wolfesberger ◽  
Zbynek Tonar ◽  
Kirsti Witter ◽  
Abigail Guija de Arespacohaga ◽  
Monika Skalicky ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Lymph Nodes ◽  
Microvessel Density ◽  
Vascular Endothelial ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Endothelial Growth Factor

Coagulopathy, Blood Loss, and Vascular Endothelial Growth Factor in Advanced Epithelial Ovarian Cancer

2006 ◽  
Vol 107 (Supplement) ◽  
pp. 107S
Author(s):  
John P. Geisler ◽  
Georgiann C. Linnemeier ◽  
Michael C. Wiemann ◽  
John Broshears ◽  
Greg A. Miller ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Blood Loss ◽  
Epithelial Ovarian Cancer ◽  
Vascular Endothelial ◽  
Advanced Epithelial Ovarian Cancer ◽  
Endothelial Growth Factor

Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival

2010 ◽  
Vol 119 (3) ◽  
pp. 479-483 ◽  
Author(s):  
Felicity Lose ◽  
Christina M. Nagle ◽  
Tracy O'Mara ◽  
Jyotsna Batra ◽  
Kelly L. Bolton ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Cancer Survival ◽  
Vascular Endothelial ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Ovarian Cancer Survival ◽  
Endothelial Growth Factor

GD3 mediated immune response via vascular endothelial growth factor in ovarian cancer

2016 ◽  
Vol 5 (S2) ◽  
pp. S248-S252
Author(s):  
Aristotle Bamias ◽  
Nikos G. Gavalas
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

The effects of vascular endothelial growth factor and microvessel density in the fibromyoma uteri

2008 ◽  
Vol 7 (10) ◽  
pp. 593-596
Author(s):  
Huaqing Wen ◽  
Jihong Deng ◽  
Ping Pu ◽  
Haitao Wang ◽  
Wei Yin
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Microvessel Density ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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