Abstract
Objectives Previous studies have shown that the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene was associated with lung cancer susceptibility, but there have been conflicts in previously reported results. Therefore, this study has evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by constructing a meta-analysis. Methods The study was performed in Web of Science, Pubmed, Cochrane Library, Embase, China Nationa Knowledge Infrastructure (CNKI) electronic database, covering relevant studies published until June 31, 2019. The heterogeneity in the study was tested by the Q-test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI). To estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. We have performed Sensitivity analysis. Using funnel plot and begger’s regression test investigated the publication bias. All data Statistical analyses were performed using Stata 12.0 and Revman 5.3. Results A total of 4307 participants (2181 patients; 2126 controls) were included in twelve case-control studies selected. No significant association was found between the ACE I/D polymorphism and lung cancer risks (II vs ID + DD: OR = 1.22, 95% CI = 0.89–1.68; II + ID vs DD: OR = 1.21, 95% CI = 0.90–1.63; I vs D: OR =1.15, 95% CI = 0.95–1.39). In the subgroup analysis by ethnicity, no significant association between this polymorphism and lung cancer risks was also found among Asia and Caucasian populations for the comparison of II vs ID + DD, II + ID vs DD and I vs D genetic models. Conclusion Our study indicated that the ACE I/D polymorphism was not associated with the risk of lung cancer.
Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies
