New candidate therapeutic agents for endometrial cancer: Potential for clinical practice (Review)

: Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre- and post-conditioning is promising.

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Antinociceptive and Anti-inflammatory like effects of Berberis baluchistanica

Current Molecular Pharmacology ◽

10.2174/1874467213666201204153045 ◽

2020 ◽

Vol 13 ◽

Author(s):

Samreen Pervez ◽

Muhammad Saeed ◽

Haroon Khan ◽

Rukhsana Ghaffar

Keyword(s):

Acetic Acid ◽

Clinical Practice ◽

Medicinal Plant ◽

Antinociceptive Effect ◽

Therapeutic Agents ◽

Toxic Effects ◽

Paw Edema ◽

Antiinflammatory Action ◽

Ear Edema ◽

Cotton Pellet

Background: Numerous therapeutic agents are in clinical practice for the treatment of inflammatory and painful conditions, but their applications has been challenged by various side /toxic effects. Therefore, new effective and safe therapies are most warrant, for which medicinal plant could be a significant alternative. Berberis baluchistanica has traditionally been used as analgesic and antiinflammatory without any scientific background. Objective: The current study was designed to evaluate the analgesic and antiinflammatory like effects of extract B. baluchistanica in animal models. Methods: For the study of antinociceptive effect, an of extract of B. baluchistanica (100, 200 and 300 mg/kg i.p.), were tested in acetic acid induced writhing and formalin tests. while for the antiinflammatory action, carrageenan induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests were used. Results: The results showed significant dose dependent antinociceptive effect of extract of B. baluchistanica in acetic acid induced writhing and formalin induced flinching behavior tests. However, the effect was strongly antagonized by the injection of naloxone, suggesting the expression via opioidergic receptors. Similarly, strong antiinflammatory action was illustrated in carrageenan induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests and thus provided evidence for the versatile phytochemical nature of its phytochemical. Background: Numerous therapeutic agents are in clinical practice for the treatment of inflammatory and painful conditions, but their applications has been challenged by various side /toxic effects. Therefore, new effective and safe therapies are most warrant, for which medicinal plant could be a significant alternative. Berberis baluchistanica has traditionally been used as analgesic and antiinflammatory without any scientific background.

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