Laryngeal carcinoma--epidemiological and clinical features: experience of the Rabin Medical Center in Israel.

Background:Polymyositis (PM) and dermatomyositis (DM) are autoimmune inflammatory diseases characterized by proximal myositis. Dysphagia has been reported to develop in 35 to 62% of PM/DM patients and known as poor prognosis factor.Objectives:The purpose of this study is to determine the clinical characteristics of PM/DM patients who present with deglutition disorder.Methods:Consecutive patients with PM/DM who visited National Hospital Organization Tokyo Medical Center between April 2010 and January 2021 are included in this study. We compared clinical features between the patients with and without dysphagia. The diagnosis of dysphagia was based on videofluorography swallow study, and dysphagia requiring gastrostomy was defined as severe dysphagia. The clinical characteristics compared in this study were following: age of onset, levels of serum creatine kinase (CK) and lactate dehydrogenase(LDH), sense of dysphagia, manual muscle test (MMT) score, and complication of malignancy or interstitial pneumonia.Results:A total of 73 patients with PM/DM were identified. Among them, 12 patients were diagnosed with dysphagia, and 5 patients developed severe dysphagia. Patients with dysphagia had the following characteristics compared to patients without dysphagia: higher levels of serum LDH (833.7 ± 500.1 U/L vs 471.9 ± 321.0 U/L, p = 0.0088), higher levels of serum CK at initial examination (6070.3 ± 7184.8 IU/L vs 1534.7 ± 2978.8 IU/L, p = 0.0086) and more frequent sense of dysphagia (90.9% vs 10.6%, p< 0.0001), lower MMT score(3.18 ± 1.07 vs 4.31 ± 0.75, p = 0.0017). In addition to those, patients with severe dysphagia presented older age of onset (mean age 69.4 ± 12.0 vs 51.7 ± 14.8, p = 0.014), more frequent complication of malignancy (80.0% vs 14.8%, p= 0.0048) and less frequent complication of interstitial pneumonia (0.0% vs 55.5%, p= 0.023).Conclusion:These results indicate that dysphagia develops frequently in PM/DM patients with higher levels of serum LDH or CK, sense of dysphagia and low MMT score. Among them, patients with elderly onset or malignancy are at risk for sever dysphagia, and should be treated carefully.Disclosure of Interests:None declared.

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Initial experience with living-related donor liver transplantation in Rabin Medical Center, Israel

Transplantation Proceedings ◽

10.1016/s0041-1345(97)00536-8 ◽

1997 ◽

Vol 29 (6) ◽

pp. 2633-2634 ◽

Cited By ~ 2

Author(s):

E. Mor ◽

N. Bar-Nathan ◽

D. Shmueli ◽

E. Shaharabani ◽

A. Yussim ◽

...

Keyword(s):

Liver Transplantation ◽

Medical Center ◽

Initial Experience ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Related Donor ◽

Living Related ◽

Living Related Donor ◽

Rabin Medical

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Experience with 100 liver transplant recipients at the Rabin Medical Center and Schneider Children’s Medical Center

Transplantation Proceedings ◽

10.1016/s0041-1345(01)02262-x ◽

2001 ◽

Vol 33 (6) ◽

pp. 2943-2944 ◽

Cited By ~ 1

Author(s):

E Mor ◽

E Shaharabani ◽

Z Ben-Ari ◽

N Bar-Nathan ◽

A Yussim ◽

...

Keyword(s):

Liver Transplant ◽

Medical Center ◽

Transplant Recipients ◽

Liver Transplant Recipients ◽

Rabin Medical

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The Clinical Features of Geriatric Ocular Trauma in a Regional Emergency Medical Center

Journal of the Korean Geriatrics Society ◽

10.4235/jkgs.2013.17.4.192 ◽

2013 ◽

Vol 17 (4) ◽

pp. 192-197

Author(s):

Jae Ho Jang ◽

Seung Woo Lee

Keyword(s):

Clinical Features ◽

Ocular Trauma ◽

Medical Center ◽

Emergency Medical

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Prevalence, clinical features and treatment pattern of patients with concurrent diagnoses of rheumatoid arthritis and psoriatic disease: results of a 14-year retrospective study in a tertiary referral center

Therapeutic Advances in Chronic Disease ◽

10.1177/2040622319847900 ◽

2019 ◽

Vol 10 ◽

pp. 204062231984790

Author(s):

Kai-Lung Chen ◽

Hsien-Yi Chiu ◽

Jui-Hsiang Lin ◽

Jian-De Ye ◽

Yi-Hsuan Cho ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Features ◽

Age Of Onset ◽

Medical Center ◽

Skin Lesions ◽

Tertiary Referral ◽

Female Ratio ◽

Tertiary Referral Center ◽

Referral Center ◽

Psoriatic Disease

Background: Multiple comorbidities, including rheumatoid arthritis (RA), have been reported to be associated with psoriasis. Objective: This study aimed to determine the prevalence and the clinical features of RA among patients with psoriasis in a tertiary referral center. Methods: Between January 2000 and December 2013, all patients coded with psoriatic disease (ICD-9 CM 696.0 OR ICD-9 CM696.1) and RA (ICD-9 CM 714.0) in a tertiary medical center were enrolled. Results: There were 10,844 patients and 9073 patients with psoriatic disease and RA identified by diagnostic codes, respectively. Among patients with psoriasis, 111 patients had claim-based diagnosis of RA (1.02%). By reviewing medical records and telephone interview or clinic visits, 25 of the 111 patients (0.23%) was identified unequivocally as having concurrent RA. Among them, 17 (68%) were female and 16 (64%) patients developed arthritis prior to the onset of psoriasis with a mean lag of 6.3 years (1–19 years); 8 (32%) had psoriasis skin lesions prior to the onset of arthritis with a mean lag of 6.9 years (3–20 years); 1 (4%) had skin lesions and arthritis in the same time; 17 (68%) patients also fulfilled the CASPAR classification criteria for psoriatic arthritis. The mean age of onset for arthritis was 49.6 years old. Conclusions: The prevalence of RA in psoriasis might be overestimated in some previous studies using claimed database. Patients with concurrent RA and psoriasis showed a comparable age of onset and male to female ratio, but had more axial involvements compared to patients without psoriasis.

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Does CSF pleocytosis have a predictive value for disease course in MS?

Neurology Neuroimmunology & Neuroinflammation ◽

10.1212/nxi.0000000000000584 ◽

2019 ◽

Vol 6 (5) ◽

pp. e584 ◽

Cited By ~ 1

Author(s):

Itay Lotan ◽

Felix Benninger ◽

Rom Mendel ◽

Mark A. Hellmann ◽

Israel Steiner

Keyword(s):

Clinical Course ◽

Medical Center ◽

Oligoclonal Bands ◽

Disease Course ◽

Disability Status ◽

Relapsing Remitting ◽

Csf Pleocytosis ◽

Csf Oligoclonal Bands ◽

Rabin Medical

ObjectiveMS is a demyelinating CNS disorder with a spectrum of clinical patterns regarding course and prognosis. Although several prognostic factors are considered in the initial evaluation of patients, biological markers defining the disease course and guiding treatments are currently lacking. It is unknown whether patients with CSF pleocytosis differ in regard to symptoms, disease course, and prognosis from those without. The aim of this study was to evaluate whether CSF pleocytosis during the initial presentation has an impact on the clinical course and progression of MS.MethodsWe retrospectively evaluated patients attending the MS Clinic at Rabin Medical Center between January 1999 and January 2016 who underwent lumbar puncture (LP) at disease presentation, considering CSF cell count, clinical diagnosis (clinically isolated syndrome [CIS] and relapsing-remitting MS [RRMS]), annualized relapse rate (ARR), paraclinical findings (imaging, CSF oligoclonal bands, and evoked potentials), and disease progression, expressed by the Expanded Disability Status Scale (EDSS).ResultsOne hundred fourteen patients (72 females) underwent LP at disease presentation (RRMS: n = 100, CIS: n = 14). Age at diagnosis was 32.4 ± 12.2 years, and the follow-up time was 9.4 ± 3.8 years. Forty-six patients showed a pleocytic CSF (≥5 cells per μL). Compared with patients with <4 cells per μL, patients with pleocytosis had a higher ARR (0.60 ± 0.09 vs 0.48 ± 0.04; p = 0.0267) and a steeper increase (slope) in the EDSS score throughout the follow-up period (correlation coefficient: r2 = 0.04; p = 0.0251).ConclusionsCSF pleocytosis may be considered a biological unfavorable predictive factor regarding disease course and progression in MS.

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