Topical Temperature-sensitive Gel Containing DsiRNA-chitosan Nanoparticles for Potential Treatment of Skin Cancer

Haliza Katas; Teh Thian Sian; Maria Abdul Ghaf

doi:10.3923/tmr.2017.1.13

Topical Temperature-sensitive Gel Containing DsiRNA-chitosan Nanoparticles for Potential Treatment of Skin Cancer

Trends in Medical Research ◽

10.3923/tmr.2017.1.13 ◽

2017 ◽

Vol 12 (1) ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

Haliza Katas ◽

Teh Thian Sian ◽

Maria Abdul Ghaf

Keyword(s):

Skin Cancer ◽

Chitosan Nanoparticles ◽

Temperature Sensitive ◽

Potential Treatment

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Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer

Recent Patents on Nanotechnology ◽

10.2174/1872210513666190702165556 ◽

2020 ◽

Vol 14 (3) ◽

pp. 210-224

Author(s):

Gayatri Patel ◽

Bindu K.N. Yadav

Keyword(s):

Particle Size ◽

Controlled Release ◽

Skin Cancer ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Chitosan Nanoparticles ◽

Entrapment Efficiency ◽

Fractional Factorial ◽

Spherical Particles

Background: The purpose of this study was to formulate, characterize and in-vitro cytotoxicity of 5-Fluorouracil loaded controlled release nanoparticles for the treatment of skin cancer. The patents on nanoparticles (US8414926B1), (US61654404A), (WO2007150075A3) etc. helped in the selection polymers and method for the preparation of nanoparticles. Methods: In the present study nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and sodium tripolyphosphate (TPP). Several process and formulation parameters were screened and optimized using 25-2 fractional factorial design. The prepared nanoparticles were evaluated for particle size, shape, charge, entrapment efficiency, crosslinking mechanism and drug release study. Results: The optimized 5-Fluorouracil loaded nanoparticle were found with particle size of of 320±2.1 nm, entrapment efficiency of 85.12%± 1.1% and Zeta potential of 29mv±1mv. Scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The invitro release profile showed controlled release up to 24 hr. Further study was carried using A375 basal cell carcinoma cell-line to elucidate the mechanism of its cytotoxicity by MTT assay. Conclusion: These results demonstrate that the possibility of delivering 5-Fluorouracil to skin with enhanced encapsulation efficiency indicating effectiveness of the formulation for treatment of basal cell carcinoma type of skin cancer.

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Anticarcinogenic Effect of Chitosan Nanoparticles Containing Syzygium aromaticum Essential Oil or Eugenol Toward Breast and Skin Cancer Cell Lines

BioNanoScience ◽

10.1007/s12668-021-00880-z ◽

2021 ◽

Author(s):

Alireza Valizadeh ◽

Ali Asghar Khaleghi ◽

Hiva Alipanah ◽

Elham Zarenezhad ◽

Mahmoud Osanloo

Keyword(s):

Skin Cancer ◽

Essential Oil ◽

Cell Lines ◽

Cancer Cell ◽

Chitosan Nanoparticles ◽

Cancer Cell Lines ◽

Syzygium Aromaticum

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Effect of peptides derived from BMP-9 on human neuroblastoma SH-SY5Y cell differentiation and their encapsulation into chitosan nanoparticles as a potential treatment for Alzheimer�s disease

Frontiers in Bioengineering and Biotechnology ◽

10.3389/conf.fbioe.2016.01.00326 ◽

2016 ◽

Vol 4 ◽

Author(s):

Lauzon Marc-Antoine ◽

Drevelle Olivier ◽

Daviau Alex ◽

Faucheux Nathalie

Keyword(s):

Cell Differentiation ◽

Chitosan Nanoparticles ◽

Potential Treatment ◽

Human Neuroblastoma

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South African plants for potential treatment and prevention against skin cancer

South African Journal of Botany ◽

10.1016/j.sajb.2018.02.135 ◽

2018 ◽

Vol 115 ◽

pp. 313

Author(s):

D. Twilley ◽

N. Kishore ◽

L. Langhansova ◽

I. Moodley ◽

H. Rolfes ◽

...

Keyword(s):

Skin Cancer ◽

South African ◽

Potential Treatment ◽

Treatment And Prevention ◽

South African Plants ◽

African Plants

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Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications

Carbohydrate Polymers ◽

10.1016/j.carbpol.2020.117199 ◽

2021 ◽

Vol 254 ◽

pp. 117199

Author(s):

Shichao Bi ◽

Ming Kong ◽

Xiaojie Cheng ◽

Xiguang Chen

Keyword(s):

Chitosan Nanoparticles ◽

Enhancement Effect ◽

Temperature Sensitive ◽

Functional Applications ◽

Self Assembling

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Oncogenesis and the Lucké Virus

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100743 ◽

1968 ◽

Vol 26 ◽

pp. 200-201

Author(s):

A. E. Vatter ◽

J. Zambernard

Keyword(s):

Rna Viruses ◽

Vegetative State ◽

Temperature Sensitive ◽

Structural Level ◽

Oncogenic Viruses ◽

Dna Viruses ◽

Leopard Frogs ◽

Renal Adenocarcinoma ◽

Induced Tumors ◽

Northern Leopard Frogs

Oncogenic viruses, like viruses in general, can be divided into two classes, those that contain deoxyribonucleic acid (DNA) and those that contain ribonucleic acid (RNA). The RNA viruses have been recovered readily from the tumors which they cause whereas, the DNA-virus induced tumors have not yielded the virus. Since DNA viruses cannot be recovered, the bulk of present day investigations have been concerned with RNA viruses.The Lucké renal adenocarcinoma is a spontaneous tumor which occurs in northern leopard frogs (Rana pipiens) and has received increased attention in recent years because of its probable viral etiology. This hypothesis was first advanced by Lucké after he observed intranuclear inclusions in some of the tumor cells. Tumors with inclusions were examined at the fine structural level by Fawcett who showed that they contained immature and mature virus˗like particles.The use of this system in the study of oncogenic tumors offers several unique features, the virus has been shown to contain DNA and it can be recovered from the tumor, also, it is temperature sensitive. This latter feature is of importance because the virus can be transformed from a latent to a vegetative state by lowering or elevating the environmental temperature.

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