NSS in Schizophrenia: Research Findings and Clinical Relevance

2003 ◽  
Vol 33 (3) ◽  
pp. 157-166 ◽  
Author(s):  
Steven F Candela ◽  
Theo C Manschreck
Keyword(s):  
Clinical Relevance ◽  
Research Findings

scholarly journals Why not to (over)emphasize statistical significance

2019 ◽  
Vol 181 (3) ◽  
pp. E1-E2 ◽  
Author(s):  
Olaf M Dekkers
Keyword(s):  
Confidence Intervals ◽  
False Positive ◽  
Clinical Relevance ◽  
Statistical Significance ◽  
Research Findings ◽  
Positive Results ◽  
Better Than

P values should not merely be used to categorize results into significant and non-significant. This practice disregards clinical relevance, confounds non-significance with no effect and underestimates the likelihood of false-positive results. Better than to use the P value as a dichotomizing instrument, the P values and the confidence intervals around effect estimates can be used to put research findings in a context, thereby taking clinical relevance but also uncertainty genuinely into account.

Clinical relevance of research findings

Ge-Bu ◽  
2019 ◽  
Vol 1-11 (1) ◽  
pp. 1
Author(s):  
KR Van Deventer ◽  
HJ Janssens
Keyword(s):  
Clinical Relevance ◽  
Research Findings

scholarly journals Clinical relevance of discoveries in psychopharmacogenetics1

2004 ◽  
Vol 10 (6) ◽  
pp. 455-465 ◽  
Author(s):  
Evangelia M. Tsapakis ◽  
Amlan Basu ◽  
Katherine J. Aitchison
Keyword(s):  
Genetic Variation ◽  
Clinical Practice ◽  
Adverse Effects ◽  
Clinical Response ◽  
Clinical Psychiatry ◽  
Mechanism Of Action ◽  
Clinical Relevance ◽  
Therapeutic Efficacy ◽  
Research Findings ◽  
Methodological Problems

Individual genetic variation accounts for some of the variability in response to drugs used routinely in clinical psychiatry. Psychopharmacogenetics focuses on how polymorphisms in genes affecting the mechanism of action of a drug's effect and/or metabolism (both peripheral and central) can influence an individual's clinical response to the drug, in terms of both therapeutic efficacy and adverse effects. Pharmacogenetics promises to be of substantial help in the field of psychiatric pharmacotherapy, but before research findings can be applied to clinical practice, ethical and methodological problems have to be addressed and overcome. This review summarises the most robust findings in the field and outlines how psychopharmacogenetic studies could lead to treatment individualisation.

scholarly journals A Framework for Analyzing the Ethics of Disclosing Genetic Research Findings

2014 ◽  
Vol 42 (2) ◽  
pp. 190-207 ◽  
Author(s):  
Lisa Eckstein ◽  
Jeremy R. Garrett ◽  
Benjamin E. Berkman
Keyword(s):  
Clinical Significance ◽  
Clinical Relevance ◽  
Clinical Utility ◽  
Genetic Research ◽  
Clinical Validity ◽  
Secondary Findings ◽  
Research Participants ◽  
The Past ◽  
Research Findings ◽  
Analytic Validity

Over the past decade, there has been an extensive debate about whether researchers have an obligation to disclose genetic research findings, including primary and secondary findings. There appears to be an emerging (but disputed) view that researchers have some obligation to disclose some genetic findings to some research participants. The contours of this obligation, however, remain unclear.As this paper will explore, much of this confusion is definitional or conceptual in nature. The extent of a researcher's obligation to return secondary and other research findings is often limited by reference to terms and concepts like “incidental,” “analytic validity,” “clinical validity,” “clinical relevance,” “clinical utility,” “clinical significance,” “actionability,” and “desirability.” These terms are used in different ways by different writers to describe obligations in different sorts of cases.

Mechanism of bilirubin elimination in urine: insights and prospects for neonatal jaundice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mercy Thomas ◽  
Winita Hardikar ◽  
Ronda F. Greaves ◽  
David G. Tingay ◽  
Tze Ping Loh ◽  
...  
Keyword(s):  
Clinical Relevance ◽  
Neonatal Jaundice ◽  
Membrane Transporters ◽  
Transport Mechanisms ◽  
Inherited Disorders ◽  
Intestinal Excretion ◽  
Bilirubin Metabolism ◽  
Research Findings ◽  
Diagnostic Importance ◽  
Conjugated Bilirubin

AbstractDespite a century of research, bilirubin metabolism and the transport mechanisms responsible for homeostasis of bilirubin in serum remain controversial. Emerging evidence on the hepatic membrane transporters and inherited disorders of bilirubin metabolism have contributed to a greater understanding of the various steps involved in bilirubin homeostasis and its associated excretory pathways. We discuss these recent research findings on hepatic membrane transporters and evaluate their significance on the newborn bilirubin metabolism and excretion. New insights gained speculate that a proportion of conjugated bilirubin is excreted via the renal system, as an alternative to the intestinal excretion, even in normal physiological jaundice with no associated pathological concerns. Finally, this paper discusses the clinical relevance of targeting the altered renal excretory pathway, as bilirubin in urine may hold diagnostic importance in screening for neonatal jaundice.

What Does Evidence-Based Practice Mean to You? A Follow-Up Study Examining School-Based Speech-Language Pathologists' Perspectives on Evidence-Based Practice

2020 ◽  
Vol 29 (2) ◽  
pp. 688-704
Author(s):  
Katrina Fulcher-Rood ◽  
Anny Castilla-Earls ◽  
Jeff Higginbotham
Keyword(s):  
Clinical Practice ◽  
Research Evidence ◽  
Evidence Based Practice ◽  
Evidence Based ◽  
Clinical Expertise ◽  
Speech Language Pathologists ◽  
School Based ◽  
Research Findings ◽  
Ebp Implementation

Purpose The current investigation is a follow-up from a previous study examining child language diagnostic decision making in school-based speech-language pathologists (SLPs). The purpose of this study was to examine the SLPs' perspectives regarding the use of evidence-based practice (EBP) in their clinical work. Method Semistructured phone interviews were conducted with 25 school-based SLPs who previously participated in an earlier study by Fulcher-Rood et al. 2018). SLPs were asked questions regarding their definition of EBP, the value of research evidence, contexts in which they implement scientific literature in clinical practice, and the barriers to implementing EBP. Results SLPs' definitions of EBP differed from current definitions, in that SLPs only included the use of research findings. SLPs seem to discuss EBP as it relates to treatment and not assessment. Reported barriers to EBP implementation were insufficient time, limited funding, and restrictions from their employment setting. SLPs found it difficult to translate research findings to clinical practice. SLPs implemented external research evidence when they did not have enough clinical expertise regarding a specific client or when they needed scientific evidence to support a strategy they used. Conclusions SLPs appear to use EBP for specific reasons and not for every clinical decision they make. In addition, SLPs rely on EBP for treatment decisions and not for assessment decisions. Educational systems potentially present other challenges that need to be considered for EBP implementation. Considerations for implementation science and the research-to-practice gap are discussed.

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

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