Diagnostic values in the infratentorial lesions by combined use of optokinetic nystagmus and fixation-suppression of caloric nystagmus.

Aim: We externally validate plasma miRNAs biomarkers for lung cancer in a large and retrospective sample set collected from a geographically distant population. Methods: Plasma samples are tested blindly to the clinical annotations by using PCR for quantitation of the four miRNAs in cohort 1 consisting of 232 lung cancer cases and 243 controls and cohort 2 comprising 239 cases and 246 controls. Results: Combined use of the four plasma miRNAs has 91% sensitivity and 95% specificity for diagnosis of lung cancer, and 85% sensitivity for early-stage lung cancer, while maintaining a specificity of 95%. Conclusion: The diagnostic values of the biomarkers are reproducibly confirmed in the independent and large sample sets, providing an assay for lung cancer detection.

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Ethanol inhibits vestibular and caloric nystagmus without affecting optokinetic nystagmus in rabbits.

The Japanese Journal of Pharmacology ◽

10.1254/jjp.50.119 ◽

1989 ◽

Vol 50 (2) ◽

pp. 119-124 ◽

Cited By ~ 1

Author(s):

Yoshie MATSUI ◽

Satoshi KASHII ◽

Masashi SASA ◽

Shuji TAKAORI ◽

Yoshihito HONDA

Keyword(s):

Optokinetic Nystagmus ◽

Caloric Nystagmus

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Studies on Caloric Nystagmus and Optokinetic Nystagmus in Elderly Japanese.

Equilibrium Research ◽

10.3757/jser.52.411 ◽

1993 ◽

Vol 52 (3) ◽

pp. 411-421

Author(s):

Keisuke Mizuta ◽

Shinji Sakuma ◽

Toshimi Kojima ◽

Hiromichi Shirato ◽

Shigeo Sawai ◽

...

Keyword(s):

Optokinetic Nystagmus ◽

Elderly Japanese ◽

Caloric Nystagmus

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Oculomotor and Vestibular Findings in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100119602 ◽

1979 ◽

Vol 6 (2) ◽

pp. 177-184 ◽

Cited By ~ 12

Author(s):

J. Dionne ◽

G. Wright ◽

H. Barber ◽

R. Bouchard ◽

J. P. Bouchard

Keyword(s):

Autosomal Recessive ◽

Optokinetic Nystagmus ◽

Vestibular Function ◽

Cerebellar Disease ◽

Ocular Pursuit ◽

Spastic Ataxia ◽

Saccade Velocity ◽

Horizontal Gaze ◽

Caloric Nystagmus ◽

Saccadic Dysmetria

SummaryElectronystagmographic recordings were made of oculomotor and vestibular function in II patients with autósomat recessive spastic ataxia of Charlevoix-Saguenay. All had horizontal gaze nystagmus, marked impairment of smooth ocular pursuit and optokinetic nystagmus, and defective fixation suppression of caloric nystagmus. Many had saccadic dysmetria. but saccade velocity was probably unaffected. Abnormallies pointing to brainstem disturbance were sparse. The findings are thought to indicate mainly diffuse cerebellar disease, with particular involvement of vermis and vestibulo-cerebellum.

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