scholarly journals Novel Pyrazolines and Benzothiazepines as Tubulin Polymerization Inhibitors: Synthesis, Biological Evaluation, and Molecular Docking

Heterocycles ◽  
2022 ◽  
Vol 104 (3) ◽  
Author(s):  
Alaadin E. Sarhan ◽  
Ashraf A. Sediek ◽  
Nagy M. Khalifa ◽  
Essam Ezzeldin
Keyword(s):  
Molecular Docking ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Tubulin Polymerization Inhibitors

Synthesis, biological evaluation, and molecular docking studies of novel chalcone oxime derivatives as potential tubulin polymerization inhibitors

RSC Advances ◽  
2014 ◽  
Vol 4 (61) ◽  
pp. 32263-32275 ◽  
Author(s):  
Yan-Ting Wang ◽  
Ya-Juan Qin ◽  
Ya-Liang Zhang ◽  
Yu-Jing Li ◽  
Bing Rao ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Molecular Docking Studies ◽  
Oxime Derivatives ◽  
Tubulin Polymerization Inhibitors

Compounds of novel chalcone oxime derivatives containing different substituent groups were designed, synthesized and evaluated for the inhibitory activity against tubulin polymerization and cancer cell inhibitory activity.

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